The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function

Zhang, Jinmin; Yu, Yu; Dang, Terry; Lal, Kevin; Wu, Hongli

doi:10.1016/j.exer.2023.109521

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2024

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“…Emerging studies also suggest that Grx1 may have other cellular functions beyond those related to redox regulation, such as modulating signal transduction pathways and potentially influencing processes like apoptosis and cell proliferation [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Molecular Tapestry: Organ-Specific Peptide and Protein Ultrafiltrates and Their Role in Therapeutics

Slivka,

Bauer,

Younsi

et al. 2024

IJMS

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This study aims to characterize the proteome composition of organ-derived protein extracts from rabbits. Protein isolation was performed using soft homogenization and size exclusion via ultrafiltration. The proteome analysis of the ultrafiltrates was conducted using gel electrophoresis, and the mass spectrometry data were subjected to gene ontology analysis. Proteomic profiling revealed comprehensive protein profiles associated with RNA regulation, fatty acid binding, inflammatory response, oxidative stress, and metabolism. Additionally, our results demonstrate the presence of abundant small proteins, as observed in the mass spectrometry datasets. Small proteins and peptides are crucial in transcription modulation and various biological processes. The protein networks identified in the ultrafiltrates have the potential to enhance and complement biological therapeutic interventions. Data are available via ProteomeXchange with identifier PXD050039.

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Section: Discussionmentioning

confidence: 99%