The Impact of Gender on Long‐Term Quality of Life After Sinus Surgery for Chronic Rhinosinusitis

Xu, Lucy; Vickery, Thad W.; Scangas, George A.; Bleier, Benjamin S.; Gray, Stacey T.; Metson, Ralph

doi:10.1002/lary.30719

Cited by 6 publications

(1 citation statement)

References 70 publications

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“…It is widely accepted that females with CRS tend to report greater symptom burden than males 6 . This has been demonstrated by several authors using the Sino‐Nasal Outcome Test (SNOT‐22) 7‐10 and the Rhinosinusitis Disability Index (RSDI) 9 .…”

Section: Discussionmentioning

confidence: 97%

Gender Differences in Adults With Chronic Rhinosinusitis: A Scoping Review

Behnke,

Dundervill,

Al‐Asadi

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveGender differences in chronic rhinosinusitis (CRS) have been demonstrated in many studies over the last 15 years. The purpose of this scoping review is to investigate the current knowledge on gender differences in CRS and to analyze the gaps in the literature.Data SourcesA systematic search of PubMed, Cochrane Library, and Embase databases was performed.Review MethodsThis scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐analyses Extension for Scoping Reviews (PRISMA‐ScR) guidelines. Studies that evaluated gender differences in CRS were included in the review.ResultsOf the 523 abstracts reviewed, a total of 23 studies met the criteria for inclusion. Articles consisted of retrospective and prospective cohort studies. They were divided into 3 categories based on whether they evaluated gender differences in (1) presentation and baseline quality of life, (2) pathophysiology, and/or (3) outcomes of treatment. Eleven studies addressed differences in presentation, 5 addressed differences in pathophysiology, and 10 dealt with differences in outcomes after surgical or medical management. Most of the studies showed worse baseline QoL secondary to CRS in women, with outcome of treatment being similar in both genders.ConclusionThe experience of CRS appears to vary between genders, with women experiencing a greater subjective burden of disease than men, though with similar outcomes after treatment. Further research is indicated, particularly involving the pathophysiology of CRS, to fully understand the underlying causes of these discrepancies.

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Section: Discussionmentioning

confidence: 97%

Gender Differences in Adults With Chronic Rhinosinusitis: A Scoping Review

Behnke,

Dundervill,

Al‐Asadi

et al. 2024

Otolaryngol.--head neck surg.

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Evaluating health utility score through direct and indirect methods in patients with chronic rhinosinusitis

Chitsuthipakorn,

Pracharktam,

Phetpong

et al. 2024

Int Forum Allergy Rhinol

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IntroductionEuroQol‐5‐dimensions‐5‐levels (EQ‐5D‐5L), visual analog scale (VAS), time trade‐off (TTO), and standard gamble (SG) are used for the assessment of Health Utility Scores (HUS) of chronic rhinosinusitis (CRS). This study aimed to determine the overall HUS of CRS, the factors which influence the HUS, and the preferable method.MethodsA cross‐sectional study was conducted. Patients with primary CRS were recruited. Clinical and socioeconomic data together with HUS were assessed. Four HUS scores determined from the four different methods were compared.ResultsA total of 335 patients were enrolled. The overall HUS, as measured by EQ‐5D‐5L, VAS, TTO, and SG, was 0.88 ± 0.14, 0.79 ± 0.17, 0.89 ± 0.15, and 0.86 ± 0.16, respectively. The multivariable linear regression revealed that each increasing 22‐item sinonasal outcome test (SNOT‐22) score predicted a reduction of 0.002 to 0.003 in HUS (all methods, p < 0.01). Patients who scheduled for endoscopic sinus surgery had 0.06 to 0.11 HUS lower than other groups in EQ‐5D‐5L and VAS (all p < 0.05). Higher endoscopy score, age, presence of comorbid airway diseases, and lower education correlated with lower HUS (p < 0.05). Given the HUS results and regression models, the EQ‐5D‐5L is likely the preferable choice.ConclusionThe overall HUS of CRS was approximately 0.79–0.89. High SNOT‐22 score and those who failed medications, presence of comorbid AR/asthma, increased age, high endoscopy score, and low education negatively impacted HUS. Our data suggest that EQ‐5D‐5L is a preferable method for measuring HUS in patients with CRS.

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Impact of sociodemographic status and sex on chronic rhinosinusitis and olfaction in people with cystic fibrosis

Han,

Liu,

Fischer

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSociodemographic status (SDS) including race/ethnicity and socioeconomic status as approximated by education, income, and insurance status impact pulmonary disease in people with cystic fibrosis (PwCF). The relationship between SDS and chronic rhinosinusitis (CRS) remains understudied.MethodsIn a prospective, multi‐institutional study, adult PwCF completed the 22‐Question SinoNasal Outcome Test (SNOT‐22), Smell Identification Test (SIT), Questionnaire of Olfactory Disorder Negative Statements (QOD‐NS), and Cystic Fibrosis Questionnaire‐Revised (CFQ‐R). Lund–Kennedy scores, sinus computed tomography, and clinical data were collected. Data were analyzed across race/ethnicity, sex, and socioeconomic factors using multivariate regression.ResultsSeventy‐three PwCF participated with a mean age of 34.7 ± 10.9 years and 49 (67.1%) were female. Linear regression identified that elexacaftor/tezacaftor/ivacaftor (ETI) use (β = ‒4.09, 95% confidence interval [CI] [‒6.08, ‒2.11], p < 0.001), female sex (β = ‒2.14, 95% CI [‒4.11, ‒0.17], p = 0.034), and increasing age (β = ‒0.14, 95% CI [‒0.22, ‒0.05], p = 0.003) were associated with lower/better endoscopy scores. Private health insurance (β = 17.76, 95% CI [5.20, 30.32], p = 0.006) and >16 educational years (β = 13.50, 95% CI [2.21, 24.80], p = 0.020) were associated with higher baseline percent predicted forced expiratory volume in one second (ppFEV1). Medicaid/Medicare insurance was associated with worse endoscopy scores, CFQ‐R respiratory scores, and ppFEV1 (all p < 0.017), and Hispanic/Latino ethnicity was associated with worse SNOT‐22 scores (p = 0.047), prior to adjustment for other cofactors. No other SDS factors were associated with SNOT‐22, QOD‐NS, or SIT scores.ConclusionsDifferences in objective measures of CRS severity exist among PwCF related to sex, age, and ETI use. Variant status and race did not influence patient‐reported CRS severity measures or olfaction in this study. Understanding how these factors impact response to treatment may improve care disparities among PwCF.Clinical TrialsNCT04469439

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The Impact of Gender on Long‐Term Quality of Life After Sinus Surgery for Chronic Rhinosinusitis

Cited by 6 publications

References 70 publications

Gender Differences in Adults With Chronic Rhinosinusitis: A Scoping Review

Gender Differences in Adults With Chronic Rhinosinusitis: A Scoping Review

Evaluating health utility score through direct and indirect methods in patients with chronic rhinosinusitis

Impact of sociodemographic status and sex on chronic rhinosinusitis and olfaction in people with cystic fibrosis

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