The impact of functional exercise on the reversal of acromegaly induced frailty: a case report

Hergott, Colleen; Lovins, Jessica

doi:10.1080/09593985.2020.1768456

Cited by 4 publications

(26 citation statements)

References 42 publications

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“…The most common study designs were randomized controlled trials (RCTs) (n = 23) [22, 23, 56-65, 24, 66-68, 49-55], quasi-experimental (n = 4) [69-72], cohort Studies (n = 3) [20,73,74], case series (n = 2) [75,76] and a case report (n = 1) [19]. Geographically, the studies took place in fteen different countries, namely Japan (n = 6) [23,56,60,65,72,74], Spain (n = 6) [20,49,66,67,70,75], United States of America (n = 4) [19,50,51,55], China (n = 3) [58, 59, 69], Sweden (n = 2) [57,62], South Korea (n = 2) [71,76], Singapore (n = 2) [22,61], Australia (n = 1) [53], Netherlands (n = 1) [52], Canada (n = 1) [73], France (n = 1) [24], Brazil (n = 1) [54], Thailand (n = 1) [63], Turkey (n = 1) [64], Denmark (n = 1) [68]. Publication dates ranged from June 23rd, 1994, to January 2nd, 2021, with most articles (n = 24) published after 2015.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Two different de nitions of frailty were used dominantly: Fried's phenotype (n = 20) [20, 22, 61, 63, 64, 66, 69-72, 75, 76, 23, 49, 51, 53, 54, 58-60], and the Frailty Index (n = 4) [24,67,71,73]. Notwithstanding, other de nitions of frailty involved the use of the clinical frailty scale [19] and checklist such as the kihon checklist [74].…”

Section: Most Least Common Frailty De Nitionsmentioning

confidence: 99%

Section: Studies Indicating Frailty Reversal Outcomementioning

confidence: 99%

“…Out of 17 studies that mentioned it was possible to reverse frailty, 11 of them had frailty reversal as an outcome [19,22,81,54,59,63,66,70,[72][73][74]. The physical domain was targeted in over 80% of the studies (n = 9) [19,23,54,59,63,66,70,72,73], while the social [74] and cognitive domains [22] were each targeted in one study. In single-component interventions such as physical activities (n = 5) [54,59,63,70,73], resistance exercises appeared to be the most common, done on its own or in combination with other physical exercises.…”

Section: Studies Indicating Frailty Reversal Outcomementioning

confidence: 99%

“…The multi-component intervention consisted of physical activity combined with either nutritional counselling/advice or supplements. Some (n = 5) of the interventions included physical activity, nutrition, plus pharmaceutical intervention in one study [72], physical activity, nutritional plus cognitive intervention in another study [22], and physical activity combined with occupational and speech therapy [19], with intervention characteristics varying across studies.…”

Section: Studies Indicating Frailty Reversal Outcomementioning

confidence: 99%

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Reversing Frailty in Older Adults: A Scoping Review

Fonka

Lewis

Lalonde

et al. 2023

Preprint

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Background: Individuals 65 years or older are presumably more susceptible to becoming frail, which increases their risk of multiple adverse health outcomes. Reversing frailty has received recent attention; however, little is understood about what it means and how to achieve it. Thus, the purpose of this scoping review is to summarize and synthesize the evidence regarding the impact of interventions on frail older adults, to determine whether the intervention (s) resulted in frailty reversal. Methods: We followed Arksey and O’Malley’s five-stage scoping review approach and conducted searches in CINAHL, EMBASE, PubMed, and Web of Science. We hand-searched the reference list of included studies and conducted a grey literature search. Two independent reviewers completed the title, abstract screenings, and full-text review using the eligibility criteria, and independently extracted approximately 10% of the studies. We critically appraised studies using Joanna Briggs critical appraisal checklist/tool, and we used a descriptive and narrative method to synthesize and analyze data. Results: Of 7499 articles, thirty met the criteria and three studies were identified in the references of included studies. Seventeen studies (56.7%) framed frailty as a reversible condition, with 11 studies (36.7%) selecting it as their primary outcome. Reversing frailty varied from either frail to pre-frail, frail to non-frail, and severe to mild frailty. We identified different types of single and multi-component interventions each targeting various domains of frailty. The physical domain was most frequently targeted (n=32, 97%). Interventions also varied in their frequencies of delivery, intensities, and durations, and targeted participants from different settings, most commonly from community dwellings (n=23; 69.7%). Conclusion: Some studies indicated that it is possible to reverse frailty. However, this depended on how the researchers assessed or measured frailty. The current understanding of reverse frailty is a shift from a frail or severely frail state to at least a pre-frail or mildly frail state. To gain further insight into reversing frailty, we recommend a concept analysis. Furthermore, we recommend more primary studies considering the participant’s lived experiences to guide intervention delivery.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Most Least Common Frailty De Nitionsmentioning

confidence: 99%

Section: Studies Indicating Frailty Reversal Outcomementioning

confidence: 99%

Section: Studies Indicating Frailty Reversal Outcomementioning

confidence: 99%

Section: Studies Indicating Frailty Reversal Outcomementioning

confidence: 99%

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Reversing Frailty in Older Adults: A Scoping Review

Fonka

Lewis

Lalonde

et al. 2023

Preprint

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Reversing frailty in older adults: a scoping review

Kolle,

Lewis,

Lalonde

et al. 2023

BMC Geriatr

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Background Individuals 65 years or older are presumably more susceptible to becoming frail, which increases their risk of multiple adverse health outcomes. Reversing frailty has received recent attention; however, little is understood about what it means and how to achieve it. Thus, the purpose of this scoping review is to synthesize the evidence regarding the impact of frail-related interventions on older adults living with frailty, identify what interventions resulted in frailty reversal and clarify the concept of reverse frailty. Methods We followed Arksey and O’Malley’s five-stage scoping review approach and conducted searches in CINAHL, EMBASE, PubMed, and Web of Science. We hand-searched the reference list of included studies and conducted a grey literature search. Two independent reviewers completed the title, abstract screenings, and full-text review using the eligibility criteria, and independently extracted approximately 10% of the studies. We critically appraised studies using Joanna Briggs critical appraisal checklist/tool, and we used a descriptive and narrative method to synthesize and analyze data. Results Of 7499 articles, thirty met the criteria and three studies were identified in the references of included studies. Seventeen studies (56.7%) framed frailty as a reversible condition, with 11 studies (36.7%) selecting it as their primary outcome. Reversing frailty varied from either frail to pre-frail, frail to non-frail, and severe to mild frailty. We identified different types of single and multi-component interventions each targeting various domains of frailty. The physical domain was most frequently targeted (n = 32, 97%). Interventions also varied in their frequencies of delivery, intensities, and durations, and targeted participants from different settings, most commonly from community dwellings (n = 23; 69.7%). Conclusion Some studies indicated that it is possible to reverse frailty. However, this depended on how the researchers assessed or measured frailty. The current understanding of reverse frailty is a shift from a frail or severely frail state to at least a pre-frail or mildly frail state. To gain further insight into reversing frailty, we recommend a concept analysis. Furthermore, we recommend more primary studies considering the participant’s lived experiences to guide intervention delivery.

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Do interventions targeting frailty improve outcomes after cardiac surgery? A systematic review

Cook,

Fredericks,

Sidani

et al. 2023

British Journal of Cardiac Nursing

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Frail patients have poorer cardiac surgery outcomes. Interventions targeting frailty may improve surgical recovery. This study explored interventions that specifically target frailty in patients undergoing cardiac surgery. A systematic review was conducted, searching multiple electronic databases from January 2010 to May 2022. Studies applying an intervention targeting frailty (measured using a validated tool) in adults undergoing cardiac surgery were included. Data extraction and quality assessments were undertaken by two authors. From 2726 identified papers, five studies were included in the final review. Studies varied in their definitions of frailty, methods and intervention components. All included an exercise component, but these varied in frequency, length and content. Three studies reported an improvement in frailty. This review identified that there is some evidence that frailty is improved after an exercise intervention. Further research should focus on the multifaceted nature of frailty, the degree to which frailty is reversed by interventions and the effectiveness of such interventions specifically for women.

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The impact of functional exercise on the reversal of acromegaly induced frailty: a case report

Cited by 4 publications

References 42 publications

Reversing Frailty in Older Adults: A Scoping Review

Reversing Frailty in Older Adults: A Scoping Review

Reversing frailty in older adults: a scoping review

Do interventions targeting frailty improve outcomes after cardiac surgery? A systematic review

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