The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study

Vassilopoulou, Εmilia; Konstantinou, George N.; Dimitriou, Anastasia; Μanios, Yannis; Koumbi, Lemonica; Papadopoulos, Nikolaos G.

doi:10.3390/nu12113402

Cited by 12 publications

(13 citation statements)

References 36 publications

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“…A high intake of seasonal fruits during pregnancy and lactation, both fresh and dried, was associated with a reduced risk of FPIAP. The seasonal availability of a wide variety of Mediterranean fruits rich in antioxidants protects against oxidative exposures, abating allergy risk during pregnancy, lactation ( 12 ) infancy ( 41 ) and childhood ( 42 , 43 ). The high fruit content of soluble dietary fibers enhances the development of a healthy intestinal microbiota ( 23 ), and fruit antioxidants, including polyphenols, carotenoids, and vitamins A and C, are anti-inflammatory ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

Food Protein-Induced Allergic Proctocolitis: The Effect of Maternal Diet During Pregnancy and Breastfeeding in a Mediterranean Population

et al. 2022

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BackgroundThe aim of the current investigation was to explore the association of food protein-induced allergic proctocolitis (FPIAP) with the maternal diet during pregnancy and breastfeeding in Greek infants.MethodsA multicenter retrospective case-control study was conducted in 6 regions in Greece, with 96 mothers of infants with and 141 mothers of infants without a history of FPIAP. Maternal dietary habits during pregnancy and breastfeeding were evaluated with the following validated questionnaires: (a) The Mediterranean Diet Score and (b) The Mediterranean Oriented Culture-Specific Semi-Quantitative Food Frequency Questionnaire.ResultsFPIAP was associated with cow's milk (83.6%), egg (7.3%), wheat (6.4%), and beef (6.4%) in the maternal diet. Adherence to Mediterranean Diet was similar among the mothers. Mothers of FPIAP infants consumed more vegetables. Elastic net prediction models showed that, in this Mediterranean population, increased consumption during pregnancy and lactation of common allergens, whole grain products, homemade food, fish and shellfish, and fruits was associated with a decreased risk of FPIAP. Conversely, a high intake of vegetables, sugar and total fat, and non-stick/grilled cooking, were associated with increased risk of FPIAP, as was a high intake of salt and white flour during lactation only.ConclusionsComponents of a maternal Mediterranean Diet may protect against FPIAP when traditional cooking methods are adopted and fish, fruit, and whole wheat products are consumed frequently during pregnancy and breastfeeding.

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Section: Discussionmentioning

confidence: 99%

Food Protein-Induced Allergic Proctocolitis: The Effect of Maternal Diet During Pregnancy and Breastfeeding in a Mediterranean Population

et al. 2022

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“…[40] Therefore, the effect of diet-derived antioxidants on tumors remains highly controversial, and there is a lack of data from large population samples. Carotene, an important food source of antioxidants, [41] is widely distributed in vegetables and fruits consumed by humans. Carotene can improve cognitive function and cardiovascular health, along with its benefits for eye health.…”

Section: Discussionmentioning

confidence: 99%

“…Carotene, an important food source of antioxidants, [41] is widely distributed in vegetables and fruits consumed by humans. Carotene can improve cognitive function and cardiovascular health, along with its benefits for eye health.…”

Section: Discussionmentioning

confidence: 99%

Genetic overlap and causal inferences between diet-derived antioxidants and small-cell lung cancer

Xiao,

Mo,

et al. 2024

Medicine

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Several studies have reported that antioxidants exert both preventive and inhibitory effects against tumors. However, their causal effects on small-cell lung cancer (SCLC) remain controversial. Herein, we explored the causal effects of 6 antioxidants on SCLC by combining a genome-wide association study database and the Mendelian randomization (MR) approach. We obtained antioxidant genetic variance data for 6 exposure factors: carotene, vitamin A (retinol), selenium, zinc, vitamin C, and vitamin E, from the genome-wide association study database. The instrumental variables for exposure factors and SCLC outcomes were integrated by screening instrumental variables and merging data. Two-sample MR was used to analyze the causal relationship between exposure and outcomes. Finally, we examined the heterogeneity and horizontal pleiotropy of the MR analysis by performing multiple sensitivity analyses. We found a causal relationship between carotene and SCLC using two-sample MR analysis and sensitivity analysis (P = .02; odds ratio = 0.73; 95% confidence interval: 0.55–0.95). In contrast, there was no causal relationship between other examined antioxidants and SCLC. We found that diet-derived circulating antioxidants could afford protection against SCLC, and carotene is the causal protective factor against SCLC.

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“…Not only genetic factors but also environmental, racial, and ethnic factors are associated with the asthma etiology; also, the dietary factors may have an active and direct impact on asthma symptoms [ 63 – 65 ]. Asthma can be triggered by exposure to many environmental factors [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes

et al. 2021

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Multiple genes have been implicated to have a role in asthma predisposition by association studies. Pediatric patients often manifest a more extensive form of this disease and a particularly severe disease course. It is likely that genetic predisposition could play a more substantial role in this group. This study is aimed at identifying the spectrum of rare and novel variation in known pediatric asthma susceptibility genes using whole exome sequencing analysis in nine individual cases of childhood onset allergic asthma. DNA samples from the nine children with a history of bronchial asthma diagnosis underwent whole exome sequencing on Ion Proton. For each patient, the entire complement of rare variation within strongly associated candidate genes was catalogued. The analysis showed 21 variants in the subjects, 13 had been previously identified, and 8 were novel. Also, among of which, nineteen were nonsynonymous and 2 were nonsense. With regard to the novel variants, the 2 nonsynonymous variants in the PRKG1 gene (PRKG1: p.C519W and PRKG1: p.G520W) were presented in 4 cases, and a nonsynonymous variant in the MAVS gene (MAVS: p.A45V) was identified in 3 cases. The variants we found in this study will enrich the variant spectrum and build up the database in the Saudi population. Novel eight variants were identified in the study which provides more evidence in the genetic susceptibility in asthma among Saudi children, providing a genetic screening map for the molecular genetic determinants of allergic disease in Saudi children, with the goal of reducing the impact of chronic diseases on the health and the economy. We believe that the advanced specified statistical filtration/annotation programs used in this study succeeded to release such results in a preliminary study, exploring the genetic map of that disease in Saudi children.

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The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study

Cited by 12 publications

References 36 publications

Food Protein-Induced Allergic Proctocolitis: The Effect of Maternal Diet During Pregnancy and Breastfeeding in a Mediterranean Population

Food Protein-Induced Allergic Proctocolitis: The Effect of Maternal Diet During Pregnancy and Breastfeeding in a Mediterranean Population

Genetic overlap and causal inferences between diet-derived antioxidants and small-cell lung cancer

Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes

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