The Impact of First Trimester Screening and Early Fetal Anomaly Scan on Invasive Testing Rates in Women with Advanced Maternal Age

Hagen, Anja; Entezami, Michael; Gasiorek-Wiens, Adam; Albig, Matthias; Becker, Rolf; Knoll, Ute; Stümm, Markus; Wegner, R. D.

doi:10.1055/s-0029-1245560

Cited by 22 publications

(15 citation statements)

References 17 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, similarly to international reports which suggest that low socioeconomic status could be a risk factor for CMs (31, 32), with socioeconomic status being determined by mother’s and father’s education level and occupation (32), we found that low education level and being unemployed was associated with significantly increased likelihood of having a baby with CM. We also found that older mother’s age is a risk factor for CMs, similarly to previous results (33, 34, 35). Even though previous reports did find an association between low birth weight and the risk of CMs (36) we did not find such an association even after controlling for a number of variables.…”

Section: Discussionsupporting

confidence: 92%

Prevalence and Factors Associated with Congenital Malformations in Tirana, Albania, During 2011-2013

et al. 2014

View full text Add to dashboard Cite

Aim:Congenital Malformations (CMs) represent a challenge especially for developing countries. Data about CMs in Albania are rather scarce. In this context, our aim was to assess the prevalence and factors associated with CMs in Tirana, the capital of Albania.Methods:Information on all CMs at birth during 2011-2013 was retrieved from the National CM Surveillance System. For each CM case, three controls (babies born without CM) were retrieved as well. Overall, 831 cases and 2522 controls were included in this study. The prevalence was calculated using the total number of live births in Tirana during the same period. Binary logistic regression was used to determine the factors associated with CMs adjusting for a number of covariates.Results:The three-year prevalence of CMs was 23.41 per 1,000 live births. The most affected body systems were the musculoskeletal, cardiovascular and genital systems. CMs were more prevalent among male babies. Advanced mothers’ age, lower education, unemployment status and lower gestational age were all positively associated with increased likelihood of CMs.Conclusions:Socio-demographic factors of mothers are linked to CMs in Albania. Future surveys are needed in Albania in order to establish determinants of CMs at a national level.

show abstract

Section: Discussionsupporting

confidence: 92%

Prevalence and Factors Associated with Congenital Malformations in Tirana, Albania, During 2011-2013

et al. 2014

View full text Add to dashboard Cite

show abstract

“…This is a well-established finding in the general population 22,24,25. Moreover, according to Chen et al,34 this finding was also observed in the ART population.…”

Section: Discussionsupporting

confidence: 67%

“…Both lower and higher maternal age may pose increased risks for birth defects 11–18. For example, older mothers have a higher risk of chromosomal abnormalities,19–22 such as Down syndrome,23–25 but whether they are at excess risk of nonchromosomal birth defects is less clear 17. It is important to have accurate information on maternal age-specific risks of birth defects after ART to gauge the implications of this rise in maternal age for public health, to gauge clinical care needs, and to provide information to couples of childbearing age 16…”

Section: Introductionmentioning

confidence: 99%

Maternal age and birth defects after the use of assisted reproductive technology in Japan, 2004–2010

Ooki¹

2013

IJWH

View full text Add to dashboard Cite

BackgroundOlder mothers are becoming more common in Japan. One reason for this is the widespread use of assisted reproductive technology (ART). This study assesses the relationship between maternal age and the risk of birth defects after ART.MethodsNationwide data on ART between 2004 and 2010 in Japan were analyzed. Diseases that were classified as code Q00-Q99 (ie, congenital malformations, deformations, and chromosomal abnormalities) in the International Classification of Diseases, tenth edition, were selected. There were 219,185 pregnancies and 153,791 live births in total ART. Of these, 1943 abortions, stillbirths, or live births with birth defects were recorded. Percentage of multiple birth defects in total birth defects, the prevalence, crude relative risk and 95% confidence interval per 10,000 pregnancies and per 10,000 live births were analyzed according to the maternal age class (ie, 25–29, 30–34 (reference), 35–39, and 40+ years).ResultsMultiple birth defects were observed among 14% of the 25–29 year old class, and 8% among other classes when chromosomal abnormalities were excluded. The prevalence of chromosomal abnormalities per pregnancy and per live birth became significantly and rapidly higher in mothers in the age classes of 30–35 and 40+ years. Nonchromosomal birth defects per pregnancy decreased linearly with advanced maternal age, while the number of nonchromosomal birth defects per live birth formed a gradual U-shaped distribution. The prevalence per pregnancy of congenital malformations of the nervous system was significantly lower with advanced maternal age. The relative risk per live birth was significant regarding congenital malformations of the circulatory system for a maternal age of 40+ years. Some other significant associations between maternal age and birth defects were observed.ConclusionMaternal age is associated with several birth defects; however, older maternal age in itself does not produce noticeable extra risk for nonchromosomal birth defects overall.

show abstract

“…Prenatal ultrasound screening is being offered earlier and earlier [9]. Large studies of noninvasive prenatal screening have already indicated that it will lead to a decrease of invasive prenatal screening procedures such as amniocentesis (AC) or chorionic villi biopsy (CVS) [10].…”

Section: Introductionmentioning

confidence: 99%

Prenatal Ultrasound Screening for Fetal Anomalies and Outcomes in High-Risk Pregnancies due to Maternal HIV Infection: A Retrospective Study

Reitter

Stücker

Buxmann

et al. 2013

Infectious Diseases in Obstetrics and Gynecology

View full text Add to dashboard Cite

Objective. To assess the prevalence of prenatal screening and of adverse outcome in high-risk pregnancies due to maternal HIV infection. Study Design. The prevalence of prenatal screening in 330 pregnancies of HIV-positive women attending the department for prenatal screening and/or during labour between January 1, 2002 and December 31, 2012, was recorded. Screening results were compared with the postnatal outcome and maternal morbidity, and mother-to-child transmission (MTCT) was evaluated. Results. One hundred of 330 women (30.5%) had an early anomaly scan, 252 (74.5%) had a detailed scan at 20–22 weeks, 18 (5.5%) had a detailed scan prior to birth, and three (0.9%) had an amniocentesis. In seven cases (2.12%), a fetal anomaly was detected prenatally and confirmed postnatally, while in eight (2.42%) an anomaly was only detected postnatally, even though a prenatal scan was performed. There were no anomalies in the unscreened group. MTCT occurred in three cases (0.9%) and seven fetal and neonatal deaths (2.1%) were reported. Conclusion. The overall prevalence of prenatal ultrasound screening in our cohort is 74.5%, but often the opportunity for prenatal ultrasonography in the first trimester is missed. In general, the aim should be to offer prenatal ultrasonography in the first trimester in all pregnancies. This allows early reassurance or if fetal disease is suspected, further steps can be taken.

show abstract

The Impact of First Trimester Screening and Early Fetal Anomaly Scan on Invasive Testing Rates in Women with Advanced Maternal Age

Cited by 22 publications

References 17 publications

Prevalence and Factors Associated with Congenital Malformations in Tirana, Albania, During 2011-2013

Prevalence and Factors Associated with Congenital Malformations in Tirana, Albania, During 2011-2013

Maternal age and birth defects after the use of assisted reproductive technology in Japan, 2004–2010

Prenatal Ultrasound Screening for Fetal Anomalies and Outcomes in High-Risk Pregnancies due to Maternal HIV Infection: A Retrospective Study

Contact Info

Product

Resources

About

The Impact of First Trimester Screening and Early Fetal Anomaly Scan on Invasive Testing Rates in Women with Advanced Maternal Age

Cited by 22 publications

References 17 publications

Prevalence and Factors Associated with Congenital Malformations in Tirana, Albania, During 2011-2013

Prevalence and Factors Associated with Congenital Malformations in Tirana, Albania, During 2011-2013

Maternal age and birth defects after the use of assisted reproductive technology in Japan, 2004&ndash;2010

Prenatal Ultrasound Screening for Fetal Anomalies and Outcomes in High-Risk Pregnancies due to Maternal HIV Infection: A Retrospective Study

Contact Info

Product

Resources

About

Maternal age and birth defects after the use of assisted reproductive technology in Japan, 2004–2010