The impact of expiration on particle deposition within the nasal cavity

Abstract

One of the most important functions of the nose is cleansing the inspired air. The aim of this study was to compare the intranasal deposition of particles during inspiration and expiration, applying different breathing manoeuvres. In nine subjects, the non-deposited particles during inhalation of an aerosol of starch particles were laser-optically detected by placing a suction probe transnasally in the anterior nasal segment. The particle deposition was measured during cyclical nose-in/nose-out (nose-only) and nose-in/mouth-out breathing. The deposited fraction was calculated in percentages. Active anterior rhinomanometry and acoustic rhinometry were performed. The mean deposited fraction in the anterior nasal segment was statistically significantly higher (P < 0.02) during nose-only breathing (46.0%) compared with nose-in/mouth-out breathing (33.0%). Our results suggest that intranasal particle deposition takes place during inspiration as well as during expiration. The period of expiration does not only seem to be important for water and heat recovery, but also for cleansing of the respiratory air.

Subject-variability effects on micron particle deposition in human nasal cavities

“…Preliminary results from in vivo and in vitro methods have confirmed the individual differences in nasal anatomy which leads to intersubject variability in aerosol deposition (Bennett & Zeman, 2005;K.-H. Cheng et al, 1996;Cheng et al, 1991Cheng et al, , 1995Y. S. Cheng et al, 1996;Cheng, 2003;Garcia, Tewksbury, et al, 2009;Kesavan et al, 2000;Kesavanathan & Swift, 1998;Kesavanathan, Bascom et al, 1998;Rasmussen et al, 2000;Wiesmiller et al, 2003). Recently, investigations using CF-PD modeling methodology also predicted subject variability in nasal deposition (Dastan et al, 2014;Garcia, Schroeter, et al, 2009;Keeler et al, 2016;Wang et al, 2008).…”

Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness

“…For example as shown by Pattle (1961), the inspiratory nasal deposition efficiency for a subject is a unique function of IP, i.e., where is the deposition efficiency and a is a correlation coefficient. Wiesmiller et al (2003) investigated the impact of expiration on particle deposition within the nasal cavity in nine subjects with particle sizes ranging from 1 to 30 m. It was found that nasal particle deposition takes place mainly during inspiration and to a much lower degree during expiration. Kesavanathan, Bascom, and Swift (1998) studied the effect of nasal passage characteristics on particle deposition with polydispersed (1.10 m) aerosols drawn unidirectionally (Q = 30 L/min) into the nose and out of the mouth for 40 subjects.…”

Voice Care Knowledge Among Clinicians and People With Healthy Voices or Dysphonia

“…51 Sivasankar and Fisher 52 report the adverse effects of short-term oral breathing and suggest a possible link that oral breathing may predispose people to vocal pathology. Nose breathing is recommended for voice use rather than mouth breathing.…”