The impact of exercise training on inflammatory markers in postmenopausal women: A systemic review and meta-analysis

Khalafi, Mousa; Malandish, Abbas; Rosenkranz, Sara K.

doi:10.1016/j.exger.2021.111398

Cited by 57 publications

(60 citation statements)

References 96 publications

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“…Similarly, Hayashino et al [ 56 ] discovered that aerobic and resistance exercises were more helpful for IL-6 in patients with type 2 diabetes when performed over a longer duration and in a larger number of sessions. Furthermore, Khalafi et al [ 57 ] reported that exercise training significantly reduced IL-6 and TNF-α in postmenopausal women in a meta-analysis of 22 studies. Generally, TNF-α is produced in adipose tissues.…”

Section: Discussionmentioning

confidence: 99%

Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kim

Yeun

2022

IJERPH

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Chronic low-grade inflammation that accompanies aging is associated with adverse health outcomes and may exacerbate the severity of infectious disease such as COVID-19. Resistance training (RT) has the potential to improve chronic low-grade inflammation, but the evidence remains inconclusive. This study evaluated the effects of RT on chronic low-grade inflammation in elderly adults. MEDLINE, EMBASE, Cochrane Library, CINAHL, RISS, NDSL, and KoreaMed were searched. We included studies that assessed the effect of RT on C-reactive protein (CRP), interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α in those aged ≥60 years. The effect size was estimated using fixed or random-effects models. Subgroup analysis was performed regarding age, health status, training method, number of exercises, intensity, weekly frequency, and duration. In the 18 randomized controlled trials (539 patients) included, RT was effective in alleviating CRP (effect size = −0.72, 95% confidence interval = −1.06 to −0.38, p < 0.001), IL-10 (−3.34, −6.16 to −0.53, p = 0.02), and TNF-α (−0.56, −1.08 to −0.03, p = 0.04) in elderly adults and tended to reduce IL-6 (−0.59, −1.18 to 0.00, p = 0.05). Subgroup analyses showed CRP reduction regardless of age, training method, number of exercises, intensity, weekly frequency, and duration. RT can be used to ameliorate chronic low-grade inflammation in elderly adults.

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Section: Discussionmentioning

confidence: 99%

Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kim

Yeun

2022

IJERPH

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“…174 Exercise training, including aerobic, resistance and combined training, reduces pro-inflammatory cytokines, namely IL-6, TNF-α and C-reactive protein (CRP), and increases adiponectin in postmenopausal women. 175 Also, in postmenopausal women, low-moderate intensity treadmill training significantly decreased inflammatory profile of IL-1β, IL-6 and TNF-α. 176 Both studies highlight F I G U R E 3 Graphical representation of the linkage pathways between hepatic steatosis and insulin resistance and regulation by oestradiol and oestrogen receptors (ERs).…”

Section: The Benefits Of Physical Activity Against the Metabolic Alte...mentioning

confidence: 89%

The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women

Molina-Molina

Furtado

Jones

et al. 2022

Eur J Clin Investigation

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Background The prevalence and severity of nonalcoholic fatty liver disease (NAFLD) increase in women after menopause. This narrative review discusses the causes and consequences of NAFLD in postmenopausal women and describes how physical activity can contribute to its prevention. Methods The authors followed the narrative review method to perform a critical and objective analysis of the current knowledge on the topic. The Medical Subject Heading keywords ‘physical exercise’, ‘menopause’, ‘hormone replacement therapy’, ‘estradiol’ and ‘NAFLD’ were used to establish a conceptual framework. The databases used to collect relevant references included Medline and specialized high‐impact journals. Results Higher visceral adiposity, higher rate of lipolysis in adipose tissue after oestrogen drop and changes in the expression of housekeeping proteins involved in hepatic lipid management are observed in women after menopause, contributing to NAFLD. Excessive liver steatosis leads to hepatic insulin resistance, oxidative stress and inflammation, accelerating NAFLD progression. Physical activity brings beneficial effects against several postmenopausal‐associated complications, including NAFLD progression. Aerobic and resistance exercises partially counteract alterations induced by metabolic syndrome in sedentary postmenopausal women, impacting NAFLD progression and severity. Conclusions With the increased global obesity epidemic in developing countries, NAFLD is becoming a severe problem with increased prevalence in women after menopause. Evidence shows that physical activity may delay NAFLD development and severity in postmenopausal women, although the prescription of age‐appropriate physical activity programmes is advisable to assure the health benefits.

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“…A recent meta-analysis comparing the independent effects of ET, ST, and CT on subcutaneous abdominal adipose tissue (SAT) in adults has shown that all these types of training lead to SAT reduction, while endurance exercise was shown to produce the greatest efficacy in decreasing SAT [ 52 ]. Several systematic reviews and meta-analyses have provided evidence of improvement in some inflammatory markers after different training sessions in various populations [ 26 , 53 , 54 , 55 , 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effect of Endurance, Strength, and Endurance-Strength Training on Inflammatory Markers and Adipokines Levels in Overweight and Obese Adults: Systematic Review and Meta-Analysis of Randomised Trials

et al. 2022

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The aim of this meta-analysis was to compare the effects of endurance, strength, and combined training on inflammatory markers and adipokine concentrations in overweight and obese adults. We performed a literature search of the Cochrane Library, PubMed, Scopus, and Web of Science databases and identified 24 randomised control trials published prior to June 2021. Our findings indicate that endurance training was significantly more beneficial than strength training in reducing C-reactive protein (CRP) (standard mean difference (SMD): −1.317, 95% confidence intervals (CI): −2.565, −0.070, p = 0.0385), interleukin 6 (IL-6) (SMD: −0.363, 95% CI: −0.648, −0.078, p = 0.0126), and visfatin (SMD: −0.618, 95% CI: −1.015, −0.222, p = 0.0023) concentrations. Moreover, combined training was more beneficial than strength training alone in lowering tumour necrosis factor-alpha (TNF-α) levels (SMD: 0.890, 95% CI: −0.301, 1.478, p = 0.0030). There were no differences between the effects of different types of training programmes on adiponectin and leptin concentrations. In conclusion, compared with strength training, endurance training is more effective in lowering CRP, IL-6, and visfatin concentrations, while combined training is more beneficial in reducing TNF-α levels in overweight and obese adults. Further studies are needed to determine which type of training has a better effect on adiponectin and leptin concentrations in this population.

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The impact of exercise training on inflammatory markers in postmenopausal women: A systemic review and meta-analysis

Cited by 57 publications

References 96 publications

Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women

Comparison of the Effect of Endurance, Strength, and Endurance-Strength Training on Inflammatory Markers and Adipokines Levels in Overweight and Obese Adults: Systematic Review and Meta-Analysis of Randomised Trials

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