The impact of excess body fat on bone remodeling in adolescents

Mosca, Luciana Nunes; Goldberg, Tamara Beres Lederer; Silva, V N da; Kurokawa, Cilmery Suemi; Rizzo, Anapaula C.B.; Silva, C C da; Teixeira, Altamir dos Santos; Corrente, José Eduardo

doi:10.1007/s00198-016-3838-6

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…Regarding the cross-sectional design of the study, this prevents the provision of information about the temporal sequence of events and does not permit identification of causal relationships. Previous studies demonstrated, through densitometry, a reduction in bone mass between those who are obese and severe/extremely obese and those with the presence of MetS [5,47], thus we propose that bone turnover markers reveal a reduction in bone remodeling in adolescents with MetS. It is suggested that both procedures are useful and complementary in bone assessment in adolescents.…”

Section: Plos Onementioning

confidence: 71%

Impact of metabolic syndrome and its components on bone remodeling in adolescents

Silva

Goldberg

Silva³

et al. 2021

PLoS ONE

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Introduction Osteoporosis and metabolic syndrome (MetS) are diseases that have serious public health consequences, reducing the quality of life of patients and increasing morbidity and mortality, with substantial healthcare expenditures. Objective To evaluate the impact of MetS on bone mineral density (BMD) and biochemical markers of bone formation and resorption in adolescents with excess weight. Method A descriptive and analytical cross-sectional study was performed that evaluated 271 adolescents of both sexes (10 to 16 years). From the total sample, 42 adolescents with excess weight and the presence of MetS (14%) were selected. A further 42 adolescents with excess weight and without MetS were chosen, matched for chronological age, bone age, and pubertal developmental criteria to those with MetS, for each sex. Anthropometric measurements, blood pressure collection, and biochemical tests were performed in all adolescents, as well as evaluation of BMD and the bone biomarkers osteocalcin (OC), bone alkaline phosphatase (BAP), and carboxy-terminal telopeptide (S-CTx). Results The adolescents with excess weight and MetS exhibited significantly lower transformed BMD and concentrations of BAP, OC, and S-CTx compared to the matched group, except for OC in boys. A negative and significant correlation was observed between total body BMD and BAP (r = -0.55568; p = 0.005), OC (r = -0.81760; p = < .000), and S-CTx (r = -0.53838; p = 0.011) in girls. Conclusion Metabolic syndrome may be associated with reduced bone mineral density and biochemical markers of bone formation and resorption in adolescents with excess weight.

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Section: Plos Onementioning

confidence: 71%

Impact of metabolic syndrome and its components on bone remodeling in adolescents

Silva

Goldberg

Silva³

et al. 2021

PLoS ONE

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“…Consistently with the results obtained by Saber et al [ 15 ] in children of 7.55±3.34 years, our study showed that osteocalcin concentrations were similar in the two groups, and revealed higher phosphorus concentrations in boys with overweight/obesity. In the study by Mosca et al [ 20 ], no statistically significant differences were found in osteocalcin concentrations between children of 10–13 years with normal weight and children with overweight/obesity.…”

Section: Discussionmentioning

confidence: 94%

Bone metabolism in children with normal weight and overweight/obesity in a northeastern region of Spain

Cuenca Alcocel,

Villalba-Heredia,

Martínez Redondo

et al. 2024

Advances in Laboratory Medicine / Avances en Medicina De Laboratorio

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Objectives Bone mass progressively increases to peak during childhood and adolescence, which determines future bone health. Bone formation–resorption processes are assessed using bone markers. However, studies on the impact of obesity on bone turnover markers at this age are limited, and results are inconsistent. The objective of this study was to examine the potential impact of overweight/obesity on bone metabolism. Methods A study was performed to compare parameters of bone metabolism in 45 girls and boys with normal weight (controls) and in a group of 612 girls and boys with overweight/obesity (cases) from the Exergames study (University of Zaragoza). Ages ranged from 8 to 12 years. Results Higher values of phosphorus and IGFBP-3 were observed in children with overweight/obesity, as compared to children with normal weight, (p=0.042) and (p=0.042), respectively. BAP, osteocalcin, magnesium, vitamin D and IGF-I concentrations were lower in the group with overweight/obesity, whereas calcium concentrations were higher in this group, although differences were not statistically significant. A negative correlation was found (r=−0.193) (p=0.049) between BAP and BMI. Conclusions Although differences did not reach statistical significance, BAP and osteocalcin concentrations were lower in children with overweight/obesity. This added to the negative correlation found between BAP and MIC may demonstrate that overweight/obesity may negatively affect bone health already at a young age.

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“…[ 15 ], realizado en un grupo de niños de 7,55 ± 3,34 años, hemos encontrado concentraciones similares de osteocalcina en los niños con sobrepeso/obesidad, frente a los niños normopeso, así como mayor concentración de fósforo en el grupo de niños con sobrepeso/obesidad. Asimismo, en el estudio de Mosca y cols [ 20 ]. tampoco se encontraron diferencias estadísticamente significativas al comparar la concentración de osteocalcina entre niños normopeso y niños con sobrepeso/obesidad de edades comprendidas entre 10 y 13 años.…”

Section: Discussionunclassified

Metabolismo óseo en niños aragoneses con normopeso y niños con sobrepeso/obesidad

Cuenca Alcocel,

Villalba-Heredia,

Martínez Redondo

et al. 2024

Advances in Laboratory Medicine / Avances en Medicina De Laboratorio

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Resumen Objetivos En la infancia y adolescencia se produce un aumento de masa ósea, hasta alcanzar un pico máximo, determinante para la salud ósea. Los marcadores óseos evalúan los procesos de formación-resorción ósea. Sin embargo, los estudios sobre la influencia de la obesidad en los marcadores de recambio óseo en esta edad, son escasos y los resultados contradictorios. El objetivo de nuestro estudio fue evaluar si el sobrepeso/obesidad influían en el metabolismo óseo. Métodos Se compararon parámetros relacionados con el metabolismo óseo, en 45 niños y niñas normopeso (controles) y en un grupo de 61 niños y niñas con sobrepeso/obesidad (casos), procedentes del estudio Exergames (Universidad de Zaragoza), de edades comprendidas, todos ellos, entre 8 y 12 años. Resultados La concentración de fósforo y la de IGFBP-3 fueron superiores en los niños con sobrepeso/obesidad, respecto a la de los niños normopeso, (p=0,042) y (p=0,042), respectivamente. Las concentraciones de BAP, osteocalcina, magnesio, vitamina D e IGF-I fueron más bajas en el grupo de los niños con sobrepeso/obesidad y la de calcio más elevada, pero las diferencias no fueron estadísticamente significativas. Existe correlación negativa (r=−0,193) (p=0,049) entre BAP e IMC. Conclusiones En los niños con sobrepeso/obesidad pese a que no se llegó a alcanzar significación estadística, la concentración de BAP y osteocalcina fue inferior a la de los niños normopeso, lo cual junto con la correlación negativa de BAP respecto al IMC encontrada, puede indicar que ya en edades tan tempranas el sobrepeso/obesidad puede afectar a la salud ósea.

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The impact of excess body fat on bone remodeling in adolescents

Abstract: The higher the fat percentage and fat mass in girls, the lower the levels of the biomarkers, indicating that excess body fat has a negative effect on the evolution of these markers during adolescence.

Cited by 7 publications

References 35 publications

Impact of metabolic syndrome and its components on bone remodeling in adolescents

Impact of metabolic syndrome and its components on bone remodeling in adolescents

Bone metabolism in children with normal weight and overweight/obesity in a northeastern region of Spain

Metabolismo óseo en niños aragoneses con normopeso y niños con sobrepeso/obesidad

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