The impact of estradiol on serotonin, glutamate, and dopamine systems
Peyton Christine Bendis,
Sydney Zimmerman,
Anna Onisiforou
et al.
Abstract:Estradiol, the most potent and prevalent member of the estrogen class of steroid hormones and is expressed in both sexes. Functioning as a neuroactive steroid, it plays a crucial role in modulating neurotransmitter systems affecting neuronal circuits and brain functions including learning and memory, reward and sexual behaviors. These neurotransmitter systems encompass the serotonergic, dopaminergic, and glutamatergic signaling pathways. Consequently, this review examines the pivotal role of estradiol and its … Show more
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