The impact of epigenetic modifications on allogeneic hematopoietic stem cell transplantation

Ktena, Yiouli P.; Dionysiou, Margarita; Gondek, Lukasz P.; Cooke, Kenneth R.

doi:10.3389/fimmu.2023.1188853

Cited by 3 publications

(2 citation statements)

References 120 publications

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“…Only 1-2% of the human genome encodes proteins, but up to 90% of the transcripts produced by the genome have no protein-coding ability. Functionally, ncRNAs are involved in various biological processes, such as cell proliferation, metabolism, and stem cell differentiation [59,60]. According to their biological functions, ncRNAs are divided into two categories: housekeeping and regulatory ncRNAs.…”

Section: Non-coding Rnas (Ncrnas)mentioning

confidence: 99%

Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem Cells

Huang,

Qing,

Xiao

et al. 2023

Biomolecules

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Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease, which is one of the common causes of hip pain and dysfunction. ONFH has a very high disability rate, which is associated with a heavy burden to patients, families, and society. The pathogenesis of ONFH is not completely clear. At present, it is believed that it mainly includes coagulation dysfunction, abnormal lipid metabolism, an imbalance of osteogenic/adipogenic differentiation, and poor vascularization repair. The prevention and treatment of ONFH has always been a great challenge for clinical orthopedic surgeons. However, recent studies have emphasized that the use of mesenchymal stem cells (MSCs) to treat steroid-induced ONFH (SONFH) is a promising therapy. This review focuses on the role and molecular mechanism of epigenetic regulation in the progress of MSCs in the treatment of SONFH, and discusses the significance of the latest research in the treatment of SONFH from the perspective of epigenetics.

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Section: Non-coding Rnas (Ncrnas)mentioning

confidence: 99%

Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem Cells

Huang,

Qing,

Xiao

et al. 2023

Biomolecules

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“…DNA methylation and other epigenetic modifications in hematopoietic stem cells (HSCs) are known to impact HSCT, and have been reviewed elsewhere 47 . Thus, it is possible that additional DNA methylation changes induced by HU treatment could affect the outcome of HSCT in SCD patients.…”

Section: Introductionmentioning

confidence: 99%

Reviewing the impact of hydroxyurea on DNA methylation and its potential clinical implications in sickle cell disease

Lewis,

Guilcher,

Greenway

2024

European J of Haematology

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Hydroxyurea (HU) is the most common drug therapy for sickle cell disease (SCD). The clinical benefits of HU derive from its upregulation of fetal hemoglobin (HbF), which reduces aggregation of the mutated sickle hemoglobin protein (HbS) and reduces SCD symptoms and complications. However, some individuals do not respond to HU, or stop responding over time. Unfortunately, current understanding of the mechanism of action of HU is limited, hindering the ability of clinicians to identify those patients who will respond to HU and to optimize treatment for those receiving HU. Given that epigenetic modifications are essential to erythropoiesis and HbF expression, we hypothesize that some effects of HU may be mediated by epigenetic modifications, specifically DNA methylation. However, few studies have investigated this possibility and the effects of HU on DNA methylation remain relatively understudied. In this review, we discuss the evidence linking HU treatment to DNA methylation changes and associated gene expression changes, with an emphasis on studies that were performed in individuals with SCD. Overall, although HU can affect DNA methylation, research on these changes and their clinical effects remains limited. Further study is likely to contribute to our understanding of hematopoiesis and benefit patients suffering from SCD.

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MicroRNA Profiles in Hematopoietic Stem Cell Transplant Recipients

Mohanraj,

Carter,

Liu

et al. 2024

Biological Research For Nursing

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Background: Hematopoietic Stem Cell Transplant (HCT) is a potentially curative treatment for hematologic malignancies, including multiple myeloma. Biomarker investigation can guide identification of HCT recipients at-risk for poor outcomes. MicroRNAs (miRNAs) are a class of non-coding RNAs involved in the modulation and regulation of pathological processes and are emerging as prognostic and predictive biomarkers for multiple health conditions. This pilot study aimed to examine miRNA profiles associated with HCT-related risk factors and outcomes in patients undergoing autologous HCT. Methods: Patients eligible for autologous HCT were recruited and blood samples and HCT-related variables were collected. Differential expression analysis of miRNA was conducted on 24 patient samples to compare changes in miRNA profile in HCT eligible patients before and after transplant. Results: Unsupervised clustering of differentially expressed ( p < .05) miRNAs pre- and post- HCT identified clusters of up- and down-regulated miRNAs. Four miRNAs (miR-125a-5p, miR-99b-5p, miR-382–5p, miR-145–5p) involved in hematopoiesis (differentiation of progenitor cells, granulocyte function, thrombopoiesis, and tumor suppression) were significantly downregulated post-HCT. Correlation analyses identified select miRNAs associated with risk factors (such as frailty, fatigue, cognitive decline) and quality of life pre- and post-HCT. Select miRNAs were correlated with platelet engraftment. Conclusion: Future studies should examine miRNA signatures in larger cohorts in association with HCT outcomes; and expand investigations in patients receiving allogeneic transplants. This will lead to identification of biomarkers for risk stratification of HCT recipients.

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The impact of epigenetic modifications on allogeneic hematopoietic stem cell transplantation

Cited by 3 publications

References 120 publications

Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem Cells

Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem Cells

Reviewing the impact of hydroxyurea on DNA methylation and its potential clinical implications in sickle cell disease

MicroRNA Profiles in Hematopoietic Stem Cell Transplant Recipients

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