The impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst

Bu, Zhiqin; Yang, Xiaoqin; Lin, Song; Kang, Beijia; Sun, Yingpu

doi:10.1186/s12958-019-0545-0

Cited by 55 publications

(52 citation statements)

References 14 publications

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“…Our indings might be agreed with (Bu et al, 2019;Riestenberg et al, 2020) results who found no beneit from endometrial compaction on increasing pregnancy rates in FET cycles. In contrast (Haas et al, 2019;Zilberberg et al, 2020) con irmed a signi icant link between EMT compaction and Ong PR, where an increasing percentage of compaction could improve Ong PR.…”

Section: Resultssupporting

confidence: 92%

Endometrial compaction and serum progesterone measurements at the day of embryo transfer cannot predict pregnancy outcomes in frozen-thaw embryo transfer cycles

Jarrah¹,

Al-Obaidi²,

Asadi³

2021

ijrps

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Endometrial receptivity plays a basic role in successful embryo implantation and pregnancy outcomes and can be assessed by many of non-invasive markers. Our study evaluated the impact of two of these markers specifically serum progesterone and endometrial thickness at embryo transfer day in prediction pregnancy outcomes on (60) patients attempting medicated frozen embryo transfer (FET) cycles. All patients were received sequential estrogen & progesterone medications for endometrial preparation then submitted to measurements of endometrial thickness (EMT) by transvaginal-ultrasound (TV-US) & serums progesterone (P) analysis at the embryo transfer day, thereafter day 3 verified-thawed embryos grades (A±B) were transferred. Compacted (decreased) EMT was seen in 48.3% of patients with higher pregnancy rate (PR) of 58.6%t than non-compacted EMT (no change or increased) which was seen in 51.7% of patients with (PR) of 29.0%, (P value=0.021). However ongoing pregnancy rate (Ong PR) not differed significantly between both groups (44.8% in compacted vs 25.8% in non-compacted, P value=0.053), also the means of serum P not differed between pregnant and non-pregnant patients (P value=0.374). ROC curves for Ong PR prediction in relations to endometrial compaction & serum progesterone at embryo transfer day were poor (AUC= 0.630, & AUC=0.576, respectively). This study suggested that endometrial compaction or serum P levels measurements at embryo transfer day were poor predictors for ongoing pregnancy where any kind of EMT changes (decreased or not) seen after P administration not significantly affect pregnancy outcomes in frozen-thaw cycles of cleavage stage embryos transfer.

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Section: Resultssupporting

confidence: 92%

Endometrial compaction and serum progesterone measurements at the day of embryo transfer cannot predict pregnancy outcomes in frozen-thaw embryo transfer cycles

Jarrah¹,

Al-Obaidi²,

Asadi³

2021

ijrps

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“…AMH is also an independent predictor of live birth outcome [31,32]. In addition, some studies reported that increased endometrial thickness is associated with better pregnancy outcome [33,34].…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes for Single Frozen-thawed Blastocyst Transfer of Day 5 and Day 6 With Different Quality: a Large Matched-cohort Study

Ren

et al. 2021

Preprint

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Background: Whether the day of blastocyst expansion affects pregnancy outcomes in frozen-thawed blastocyst transfer (FBT) cycles remains controversial. The conflicting results may be attributed to the potential confounders of FBT cycles between day 5 and day 6. The aim of this study is to compare the clinical pregnancy rate (CPR) and live birth rate (LBR) of FBT cycles on day 5 versus day 6 accounting for the baseline comparability and determine the transfer order of FBT cycles.Methods: This was a retrospective match-cohort study, FBT cycles of day 5 and day 6 were matched by the general characteristics of patients, 2207 matched pairs of FBT cycles were included from January 2016 to December 2019 in our reproductive medicine center.Results: The CPR and LBR of day 5 blastocyst were significantly higher than day 6 with the same quality. In the FBT cycles with good quality, the CPR of day 5 and day 6 was 61.30%, 57.56% respectively (P=0.045), the LBR was 44.79%, 36.16% respectively (P<0.001). While in the FBT cycles with poor quality, the CPR of day 5 and day 6 was 48.61%, 40.89% respectively (P=0.006), the LBR was 31.71%, 25.74% respectively (P=0.019). The CPR of FBT cycles on day 6 with good quality was statistically higher than day 5 with poor quality (57.56% versus 48.61%, P=0.001). Maternal age, AMH, endometrial thickness, embryo quality and the day of blastocyst expansion was independently correlated with CPR and LBR. The FBT cycles of day 5 exhibited significantly higher CPR [adjusted odds ratio (OR)=1.246, 95% confidence intervals (Cl): 1.097-1.415, P=0.001] and LBR (adjusted OR=1.435, 95% Cl: 1.258-1.637, P<0.001) compared with day 6.Conclusions: The embryo quality should be the primary indicator in the FBT cycles. The blastocyst of day 5 should be preferred if the embryo quality of day 5 and day 6 is equal.Trial registration: Not applicable.

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“…The increase in VEGF in turn regulates the angiogenesis of the endometrium and stimulates further growth of the endometrium [9]. In a single-center retrospective control study, Zhiqin Bu found that an increased endometrial thickness after progesterone administration was associated with better pregnancy outcomes for thawed blastocyst cycles [10]. The possible reason for this con icting result is that all of our research objects were cleavage-stage embryo transfer, with the transfer period being in the early luteal phase, in contrast to that of the blastocyst transfer, which is closer to the middle luteal phase.…”

Section: Discussionmentioning

confidence: 99%

Decreased endometrial thickness between HCG day and embryo transfer day improves the pregnancy rate of IVF/ICSI cycles

Wang

Deng

Wang

et al. 2020

Preprint

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Background Previous studies have suggested that pregnancy outcome and endometrial thickness before embryo transfer are closely related. However, we found that endometrial thickness changed even within a few days between HCG day and embryo transfer day. There have been few studies on the relationship between endometrial thickness change (ETC) and pregnancy outcomes. The aim of this study was to assess whether the ETC from HCG trigger day to embryo transfer day affects pregnancy outcomes of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles. Methods This was a retrospective single-center cohort study. In total, 9773 IVF/ICSI embryo transfer cycles involving the long protocol at Chongqing Reproductive and Genetics Institute from January 1st, 2016, to December 30th, 2019, were included. The 9773 cycles were divided into 2 groups based on whether the endometrial thickness decreased from HCG day to embryo transfer day, and clinical pregnancy rates (CPRs) and ongoing pregnancy rates (OPRs) were compared. Logistic regression was used to determine whether an ETC was an independent risk factor for CPR or OPR. Results The CPR and OPR of the decreased endometrial thickness group were higher than those of the non-decreased endometrial thickness group (62.65% and 52.6% vs. 60.56% and 50.18%) (p = 0.041 vs. 0.027). The endometrial thickness change was an independent risk factor for CPR (OR = 0.920, P = 0.003, 95% confidence interval 0.870–0.972) and OPR (OR = 0.907, P = 0.000, 95% confidence interval 0.859–0.958) Conclusions A proper decrease in endometrial thickness from HCG trigger day to embryo transfer day in IVF/ICSI cycles increases the CPR and OPR.

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The impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst

Cited by 55 publications

References 14 publications

Endometrial compaction and serum progesterone measurements at the day of embryo transfer cannot predict pregnancy outcomes in frozen-thaw embryo transfer cycles

Endometrial compaction and serum progesterone measurements at the day of embryo transfer cannot predict pregnancy outcomes in frozen-thaw embryo transfer cycles

Pregnancy Outcomes for Single Frozen-thawed Blastocyst Transfer of Day 5 and Day 6 With Different Quality: a Large Matched-cohort Study

Decreased endometrial thickness between HCG day and embryo transfer day improves the pregnancy rate of IVF/ICSI cycles

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