The Impact of Endocrine Therapy on Cognitive Functions of Breast Cancer Patients: A Systematic Review

Bakoyiannis, Ioannis; Tsigka, Eleousa-Alexandra; Perrea, Despina; Pergialiotis, Vasilios

doi:10.1007/s40261-015-0364-9

Cited by 38 publications

(29 citation statements)

References 53 publications

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“…These findings, although not confirmatory, may indicate that ET, when used as part of a multi-modal treatment regimen, may not, by itself, be associated with cognitive dysfunction. A recent meta-analysis concluded that further longitudinal study of endocrine therapy on cognition in women treated for breast cancer is needed to more conclusively establish this complex relationship (Bakoyiannis et al 2015). …”

Section: Discussionmentioning

confidence: 99%

The relationship of cognitive performance to concurrent symptoms, cancer- and cancer-treatment-related variables in women with early-stage breast cancer: a 2-year longitudinal study

Lyon

Cohen

Chen

et al. 2016

J Cancer Res Clin Oncol

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Purpose Cognitive dysfunction in women with breast cancer continues to be an area of intense research interest. The prevalence, severity, timing, and cognitive domains that are most affected, as well as the contribution of cancer and its treatments to cognition, remain unresolved. Thus, longitudinal studies are needed that examine cognitive function during different stages of breast cancer treatment and survivorship. This longitudinal trial followed women with early-stage breast cancer, prior to chemotherapy through 2 years survivorship. Methods In women with early-stage breast cancer (N = −75), performance-based assessment of nine cognitive domains was performed at five time points beginning prior to chemotherapy and finishing 24 months after initial chemotherapy. Linear mixed effects models were used to examine the temporal changes in cognitive performance domains, while adjusting for cofactors, including those related to individuals, tumor attributes, chemotherapy (adjuvant or neoadjuvant), radiation, endocrine therapy, and concurrent symptoms. Results At baseline, scores on reaction time, complex attention, cognitive flexibility, executive function, and visual memory were lower than 90. At 2 years, all domains improved except for the memory domains (verbal, visual, and composite). Scores on six domains (psychomotor speed, reaction time, complex attention, cognitive flexibility, and visual memory) remained lower than 100 at 2 years. Neoadjuvant chemotherapy and fatigue had strong inverse relationship with cognitive functioning at multiple time points. Conclusion The low performance-based cognitive scores at baseline and over time warrant further study. Although most scores improved over time, memory did not improve. In all, the level of cognitive function is lower than expected for a majority college-educated sample. Thus, future studies are warranted to replicate these findings and to develop methods for identifying women with cognitive dysfunction pretreatment and into survivorship.

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Section: Discussionmentioning

confidence: 99%

The relationship of cognitive performance to concurrent symptoms, cancer- and cancer-treatment-related variables in women with early-stage breast cancer: a 2-year longitudinal study

Lyon

Cohen

Chen

et al. 2016

J Cancer Res Clin Oncol

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“…Since 2010, eight reviews have been published addressing the association of hormone therapy with cognitive impairment in breast cancer patients [20■■, 21■■, 22–26, 27■], demonstrating high interest in this topic. In this section, emphasis will be placed on the two systematic reviews and a recent narrative review [21■■].…”

Section: Effects Of Ht In Women With Breast Cancermentioning

confidence: 99%

“…A systematic review by Bakoyiannis et al [27] includes 12 studies published before July 2015. Studies contrasting hormone therapy with no hormone therapy patients or healthy controls were mixed with studies contrasting different hormone therapy regimens (SERMs vs. aromatase inhibitors).…”

Section: Effects Of Ht In Women With Breast Cancermentioning

confidence: 99%

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Cognitive impairment following hormone therapy: current opinion of research in breast and prostate cancer patients

Amidi

2017

Current Opinion in Supportive &Amp; Palliative Care

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Purpose of review Hormone therapy is a common cancer treatment that may be associated with numerous side and late effects, and in recent years, has been linked to changes in cognition. Here, we present the most important recent findings from empirical studies and reviews that have focused on the effects of hormone therapy on cognitive functioning in breast and prostate cancer populations, underline some general shortcomings, and propose directions for future research. Recent Findings Recent research indicates that cognitive impairment may occur in breast and prostate cancer patients following onset of hormone therapy. However, due to methodological shortcomings and heterogeneity of current research, conclusions regarding the effects of hormone therapy on cognitive functions remain tentative. Summary This review highlights the general findings whilst also describing the many methodological shortcomings that need to be addressed in future research. It is clear that larger scale neuropsychological studies that also evaluate the impact of impairments on daily life functioning will improve our understanding of the effects of hormone therapy on cognition and inform the development of appropriate interventions.

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“…These symptoms, generally known as chemobrain or chemofog, are experienced by a lot of women cured with chemotherapy [4]. Bakoyiannis, and colleagues [12] conducted a systematic review on the impact of endocrine therapy on cognitive functions of breast cancer patients. They especially investigated difficulties in five cognitive domains: verbal memory, verbal fluency, attention and working memory, motor speed and psychomotor speed.…”

Section: Introductionmentioning

confidence: 99%

Training Cognitive Functions Using Mobile Apps in Breast Cancer Patients: Systematic Review

Vergani¹,

Marton²,

Pizzoli³

et al. 2019

JMIR Mhealth Uhealth

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BackgroundBreast cancer is an invalidating disease and, in particular, its treatment can bring serious side effects that have a physical and psychological impact as well. Specifically, cancer's treatment generally has a strong impact on cognitive function. In the last years, new technologies and eHealth had proved to have a growing influence on health care and innovative mobile applications can be a useful tool to deliver cognitive exercise in the patient's home.

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The Impact of Endocrine Therapy on Cognitive Functions of Breast Cancer Patients: A Systematic Review

Abstract: ET among breast cancer patients seems to negatively alter the cognitive outcomes of breast cancer patients. However, the methodological heterogeneity of the included studies, as well as the relatively small follow-up period, render imperative the conduct of further studies in the field.

Cited by 38 publications

References 53 publications

The relationship of cognitive performance to concurrent symptoms, cancer- and cancer-treatment-related variables in women with early-stage breast cancer: a 2-year longitudinal study

The relationship of cognitive performance to concurrent symptoms, cancer- and cancer-treatment-related variables in women with early-stage breast cancer: a 2-year longitudinal study

Cognitive impairment following hormone therapy: current opinion of research in breast and prostate cancer patients

Training Cognitive Functions Using Mobile Apps in Breast Cancer Patients: Systematic Review

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