The impact of ejaculatory abstinence on semen analysis parameters: a systematic review

Hanson, Brent M.; Aston, Kenneth I.; Jenkins, Timothy G.; Carrell, Douglas T.; Hotaling, James M.

doi:10.1007/s10815-017-1086-0

Cited by 56 publications

(64 citation statements)

References 23 publications

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“…The chart on the right shows the age-adjusted regression line slope coefficients with their 95% confidence intervals contrasting BMI with WHR as they relate to progressive motility days). As a matter of fact, systematic review by Hanson et al found that semen parameters are lower before and abstinence of 3 days and higher after 5 days, but within 3 and 5 those parameters are not different [28]. Another limitation is that, since this is an exploratory study comparing BMI with WHR, we did not assess any other biological markers besides the selected fertility characteristics, or any other potential control variables besides age.…”

Section: Discussionmentioning

confidence: 93%

The potential role of central obesity in male infertility: body mass index versus waist to hip ratio as they relate to selected semen parameters

et al. 2020

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Background: Little is known about the potential role of central obesity among men. Our first aim was to confirm what is already known from prior research, namely that both BMI and WHR are inversely associated with selected semen parameters. Our second aim was to examine the potential role of central obesity by assessing if there was a difference between BMI and WHR regarding their relationships to these selected semen parameters. Methods: In this cross-sectional study between January 2011 to January 2018, we analyzed semen samples from 1169 patients who visited an andrology clinic in Budapest for infertility reasons. Variables assessed were: body measurements (height, weight, waist circumference, and hip circumference), and the results of semen analysis (sperm concentration, total sperm count, progressive sperm motility, and normal sperm morphology). Results: The mean height and weight were 180.6 cm and 87.3 kg, respectivelythe mean BMI was 26.8. The mean waist and hip circumferences were 100.9 cm and 94.8 cm, respectivelythe mean waist to hip ratio was 0.94. The mean sperm concentration, total sperm count, and percents of progressive motility and normal morphology were 48.7 M/ml, 165 million, 21.2, and 4.8%, respectively. Both BMI and WHR were significant correlates in all semen parameter regression models. When comparing the parameter estimates for BMI with those for WHR for each semen parameter, the parameter estimate for WHR was significantly lower (indicating a stronger negative association) than that for BMI for progressive motility and total sperm count, but not for normal morphology or concentration. Conclusions: Our study is the first to examine, using a large patient sample, the potential role of central obesity by comparing the difference between BMI and WHR as they relate to selected semen parameters. Our findings indicate a potential role of central obesity for progressive motility and total sperm count, but not for normal morphology and concentration. Despite the limitations and the exploratory nature of this study, we can conclude that our results point to a potential role of central obesity in male infertility, but this finding should be confirmed and further explored in future research.

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Section: Discussionmentioning

confidence: 93%

The potential role of central obesity in male infertility: body mass index versus waist to hip ratio as they relate to selected semen parameters

et al. 2020

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“…A recent systematic review of 28 studies suggested that longer EA is associated with increased semen volume and sperm count, which is also in agreement with our findings. On the other hand, the study reported that effect of EA on sperm motility, morphology and DNA fragmentation rates is controversial, despite a trend towards improvements in semen parameters with shorter abstinence appears to exist (Hanson et al ., ). Long periods of EA may induce senescence of spermatozoa, producing damage at a functional level that may not be recognized by conventional semen analysis.…”

Section: Discussionmentioning

confidence: 97%

Revisiting the impact of ejaculatory abstinence on semen quality and intracytoplasmic sperm injection outcomes

et al. 2018

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Background: Regulatory bodies recommend inconsistent ejaculatory abstinence lengths before semen analysis. The literature exploring the effect of ejaculatory abstinence length on the outcomes of intracytoplasmic sperm injection is scarce. Objective: To study the influence of ejaculatory abstinence length on semen quality and intracytoplasmic sperm injection outcomes. Materials and methods: This prospective cohort study included 818 patients undergoing conventional semen analysis from October 2015 to October 2016, in a private university-affiliated IVF centre. Generalized linear models adjusted for potential confounders were used to investigate the associations between ejaculatory abstinence length and seminal parameters and intracytoplasmic sperm injection outcomes. Results: Increasing ejaculatory abstinence length was positively correlated with semen volume, sperm concentration, total sperm count, total motile sperm count and sperm DNA fragmentation index. Significant inverse correlations were observed between ejaculatory abstinence length and fertilization rate, blastocyst formation rate, implantation rate and pregnancy rate. A discriminant analysis showed a mean ejaculatory abstinence length in the positive pregnancy group of 3.14 AE 1.64 days and 4.83 AE 3.66 days in the negative pregnancy group. A cut-off point was established halfway between ejaculatory abstinence length averages, at 4 days. The ejaculatory abstinence ≤4 days group showed significant lower semen volume, sperm concentration, total sperm count and total motile sperm count compared to ejaculatory abstinence > 4 days group. The ejaculatory abstinence ≤ 4 days group showed significant lower sperm DNA fragmentation index, and higher rates of fertilization, high-quality embryos on day 3, blastocyst development, implantation and pregnancy compared to ejaculatory abstinence > 4 days group. The implantation rate was significantly higher and the pregnancy rate tended to be higher with one day of ejaculatory abstinence, compared to 2-4 days of ejaculatory abstinence. Conclusions: Ejaculatory abstinence periods of >4 days have a detrimental effect on sperm DNA and intracytoplasmic sperm injection outcomes. One day of ejaculatory abstinence significantly improves implantation rate and tends to increase pregnancy rate, compared to 2, 3 and 4 days of ejaculatory abstinence.

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“…Progressive motility is an important basis for evaluating sperm motility, while sperm concentration and the rate of acrosomal reaction are both related to fertilisation and pregnancy rates (Kon et al, ; Yavuz, Demirci, Sozen, & Uludogan, ). The rate of sperm DNA fragmentation is an indicator of semen stability; an increase in DNA fragmentation results in a decline in semen quality (Hanson, Aston, Jenkins, Carrell, & Hotaling, ). These indicators are affected by a range of factors that are associated with complex mechanisms, including demographic characteristics (Lund & Sorensen, ), lifestyle habits (Osser, Beckman‐Ramirez, & Liedholm, ; Ventrice, Ventrice, Russo, & De Sarro, ), eating habits (Adelusi et al, ), and environment (Dobrzynska, Tyrkiel, Derezinska, Pachocki, & Ludwicki, ).…”

Section: Discussionmentioning

confidence: 99%

Cyclooxygenase 1 (COX1) as an indicator of sperm quality in humans

2020

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Sperm quality is important for in vitro fertilisation and embryo transfer and intracytoplasmic sperm injection in the treatment of human infertility. The purpose of this study was to screen for biomarkers that could evaluate sperm quality. We analysed semen samples in 172 fertile males; multivariate logistic regression analysis showed that the levels of COX1 (17.5 ng/ml) in seminal plasma may represent a useful biomarker for sperm quality (area under the curve: 0.745; sensitivity: 0.808; specificity: 0.722). Analysis indicated that the values of parameters related to sperm quality changed significantly (p < .05) between COX1 level ≥ 17.5 ng/ml group and COX1 level < 17.5 ng/ml group. Further analysis of two consecutive semen samples (1‐hr interval) from 48 subjects revealed that the first semen samples (COX1 levels ≥ 17.5 ng/ml) had a higher sperm concentration and a larger proportion of spermatozoa showing progressive motility, a lower rate of sperm DNA fragmentation and a lower proportion of spermatozoa undergoing the acrosome reaction spontaneously (p < .05); identical results were observed for the second semen samples. These data indicated that COX1 could be used as an indicator for sperm status and may be helpful for identifying better quality spermatozoa for artificial insemination.

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The impact of ejaculatory abstinence on semen analysis parameters: a systematic review

Cited by 56 publications

References 23 publications

The potential role of central obesity in male infertility: body mass index versus waist to hip ratio as they relate to selected semen parameters

The potential role of central obesity in male infertility: body mass index versus waist to hip ratio as they relate to selected semen parameters

Revisiting the impact of ejaculatory abstinence on semen quality and intracytoplasmic sperm injection outcomes

Cyclooxygenase 1 (COX1) as an indicator of sperm quality in humans

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