The Impact of Early Adequate Treatment on Extubation and Discharge Alive of Patients With Pseudomonas aeruginosa-Related Ventilator-Associated Pneumonia*

Abstract

Early adequate treatment does not seem to be associated with an improved prognosis. Its potential benefit requires further investigation in larger observational studies.

Pathophysiological role of respiratory dysbiosis in hospital-acquired pneumonia

“…16 Optimisation of antimicrobial therapy is important but can no longer be expected to improve patient outcomes. For example, inadequate empiric anti microbial therapy is not associated with outcomes of Pseudomonas aeruginosaassociated hospital-acquired pneumonia, 17 and optimisation of the pharmacokinetics of antibiotics did not result in more patients being cured in randomised controlled trials that evaluated the dose adaptation to the blood levels measured during the treatment. 18 Clinical cure (defined as the clinical resolution of hospitalacquired pneumonia) did not consistently occur with bacteriological cure (defined as the eradication of the dominant pathogen at the end of treatment).…”