The impact of dyslipidemia and oxidative stress on vasoactive mediators in patients with renal dysfunction

Jabarpour, Maryam; Rashtchizadeh, Nadereh; Argani, Hassan; Ghorbanihaghjo, Amir; Ranjbarzadhag, Masoumeh; Sanajou, Davoud; Panah, Fatemeh; Alirezaei, Amirhesam

doi:10.1007/s11255-019-02319-7

Cited by 22 publications

(16 citation statements)

References 72 publications

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“…Dyslipidemia in MetS is a state with elevated level of plasma TG associated with increased level of very low-density lipoprotein (VLDL), small, dense LDL (sdLDL-C), FFAs and low HDL cholesterol level that promotes the development of atherosclerosis [113]. Indeed, oxidatively modified LDL (ox-LDL) is an important player in inducing the process of atherosclerosis as it affects expression of adhesive molecules, cytokines and growth factors and changes function of important vasoactive molecules such as NO, angiotensin II (Ang II) or endothelin 1 (ET 1) [114,115]. Interestingly, treatment of MetS patients with rosuvastatin causes beneficial effect not only on levels of ox-LDL, HDL, and inflammatory markers, but also ameliorates total antioxidant capability [116].…”

Section: Dyslipidemia and Oxidative Stressmentioning

confidence: 99%

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Włodarski

Strycharz

Wróblewski

et al. 2020

IJMS

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Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the incidence and economic burden of which is increasing each year. OxS triggers the dysregulation of signaling pathways associated with metabolism and epigenetics, including microRNAs, which are biomarkers of metabolic disorders. In this review, we aimed to summarize the current knowledge regarding the interplay between microRNAs and OxS in MetS and its components. We searched PubMed and Google Scholar to summarize the most relevant studies. Collected data suggested that different sources of OxS (e.g., hyperglycemia, insulin resistance (IR), hyperlipidemia, obesity, proinflammatory cytokines) change the expression of numerous microRNAs in organs involved in the regulation of glucose and lipid metabolism and endothelium. Dysregulated microRNAs either directly or indirectly affect the expression and/or activity of molecules of antioxidative signaling pathways (SIRT1, FOXOs, Keap1/Nrf2) along with effector enzymes (e.g., GPx-1, SOD1/2, HO-1), ROS producers (e.g., NOX4/5), as well as genes of numerous signaling pathways connected with inflammation, insulin sensitivity, and lipid metabolism, thus promoting the progression of metabolic imbalance. MicroRNAs appear to be important epigenetic modifiers in managing the delicate redox balance, mediating either pro- or antioxidant biological impacts. Summarizing, microRNAs may be promising therapeutic targets in ameliorating the repercussions of OxS in MetS.

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Section: Dyslipidemia and Oxidative Stressmentioning

confidence: 99%

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Włodarski

Strycharz

Wróblewski

et al. 2020

IJMS

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“…Additionally, the persistent hyperglycemia and hyperlipidemia are associated with elevation of ROS and reduction of antioxidant enzymes (35). Oxidative stress and dislipidemia result in chronic kidney disease and nephropathy (38). Thus in the present work, streptozotocinnicotinamide resulted in abnormalities in the liver and kidney functions.…”

Section: Discussionmentioning

confidence: 51%

Efficiency of a formulated condiment (duqqa) in mitigation of diabetes and its complications induced by streptozotocin-nicotinamide in rats

Mohamed

Abdel-Salam

2021

J Herbmed Pharmacol

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Introduction: Duqqa is a condiment, consisting of black pepper, cumin, sesame, coriander and high amount of salt. Reducing salt and adding other beneficial items to traditional duqqa can make it suitable dietary supplement for diabetes management. The current study aimed to assess the effect of a modified duqqa on diabetes and its complications in diabetic rats. Methods: The modified duqqa was formulated by mixing grounded fermented wheat, sesame, coriander, cumin, chicory leaves, cinnamon, turmeric and date seeds powder and studied in diabetic rats which were developed by streptozotocin-nicotinamide injection. Thirty-two rats were divided into four groups (n = 8) including non-diabetic, diabetic control and the other two groups fed on balanced diet supplemented with either 10 or 20% of duqqa prior the induction of diabetes (for one week) to the end of the experiment (8 weeks). Results: The dietary supplementation with 10 and 20% of the formulated duqqa prior the induction of diabetes did not delay the onset of diabetes in rats but produced reduction (32.56% and 50.47%, respectively) in the glucose levels of diabetic rats. Also, diabetic rats fed on the formulated duqqa showed insulin concentrations higher than that of diabetic control rats. Feeding diabetic rats on the formulated duqqa reversed the elevation of kidney lipid peroxidation and nitric oxide, limited the disturbance in the lipid profile as well as liver and kidney functions and elevated both serum and femur magnesium concentrations. Conclusion: The results indicated the hypoglycemic effect of the formulated duqqa and its efficiency in delaying diabetes complications.

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“…The speculated theories pay significant attention to oxidative stress [23,24], understood as disturbances in the reactive oxygen species (ROS) production-degradation balance [25]. As such, this phenomenon is involved in the etiopathogenesis of numerous diseases, such as atherosclerosis, reduced kidney function, or ischemic stroke [26][27][28]. Recently, it is also considered to be one of the factors leading to the development of neurodegenerative and neuroinflammatory diseases of the central nervous system, e.g., multiple sclerosis, Alzheimer's disease, or Parkinson's disease [25,29,30].…”

Section: The Role Of Oxidative Stress In the Pathophysiology Of Migrainementioning

confidence: 99%

The Use of Antioxidants in the Treatment of Migraine

et al. 2020

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Despite numerous studies concerning the pathophysiology of migraine, the exact molecular mechanism of disturbances underlying migraine is still unknown. Furthermore, oxidative stress is considered to play a significant role in migraine pathogenesis. The notion of oxidative stress in migraine patients has been discussed for several decades. Over the past few years, among the substances that could potentially be used for migraine treatment, particular attention has been paid to the so-called nutraceutics, including antioxidants. Antioxidants supplied with food prevent oxidative stress by inhibiting initiation, propagation, and the oxidative chain reaction itself. Additionally, the agents used so far in the prevention of migraine indeed show some anti-oxidative action. The antioxidants discussed in the present paper are increasingly more often used by migraine patients not only due to mild or even a lack of side effects but also because of their effectiveness (decreased frequency of migraine episodes or shortening of an episode duration). The present review provides a summary of the studies on nutraceuticals with antioxidative properties.

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The impact of dyslipidemia and oxidative stress on vasoactive mediators in patients with renal dysfunction

Cited by 22 publications

References 72 publications

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Efficiency of a formulated condiment (duqqa) in mitigation of diabetes and its complications induced by streptozotocin-nicotinamide in rats

The Use of Antioxidants in the Treatment of Migraine

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