“…Increased donor age is the most important variable when defining an ECD, and stroke as a cause of death and longstanding arterial hypertension are associated with poorer graft survival. 2,21,33,74,75 Kidneys from older donors are more susceptible to ischaemia -reperfusion injury A and DGF -which in turn increases the risk of acute rejection and reduced graft survival. 24,26,76 Older kidneys have reduced nephron mass, further affected by ischaemia and immunosuppressive medication.…”