The impact of different fixatives on immunostaining of lung adenocarcinomas in pleural effusion cell blocks
Mohammed S. I. Mansour,
Louise Pettersson,
Tomas Seidal
et al.
Abstract:BackgroundCell blocks (CBs) are widely used for biomarker analyses such as immunostaining. Although immunohistochemistry on formalin‐fixed paraffin‐embedded tissues is standardized, there are multiple preparation methods and fixatives for cytology. Our objective was to investigate the effect of different common fixatives on the immunoreactivity of pleural effusion CBs with metastatic lung adenocarcinomas.MethodsThis prospective study included 24 malignant pleural effusions from different patients with lung ade… Show more
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