The impact of dietary sn-2 palmitic triacylglycerols in combination with docosahexaenoic acid or arachidonic acid on lipid metabolism and host faecal microbiota composition in Sprague Dawley rats

Wan, Jing; Hu, Songyou; Jacoby, Jörg J.; Liu, Jie; Zhang, Yaqiong; Yu, Liangli

doi:10.1039/c7fo00094d

Cited by 30 publications

(19 citation statements)

References 49 publications

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“…Intake of long‐chain SFAs may increase lipid deposition, while MUFAs or PUFAs would inhibit lipid deposition . Such an effect could be dependent upon the fatty acid β‐oxidation, mRNA fatty acid synthase, and sterol regulatory element binding protein‐1c expression . Although the changes in body weight gain and feed intake, no significant difference was observed in inflammatory cytokines in the present study.…”

Section: Discussioncontrasting

confidence: 52%

Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle‐Aged Rats by Suppressing the Glycosylation Process

Zhou

Li³

et al. 2018

Molecular Nutrition Food Res

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ScopeDietary fats have been shown to affect gut microbiota composition and aging gene expression of middle‐aged rats at a normal dose, but little is known about such an effect on gut barrier. In this study, the changes in colonic Muc2 expression are investigated and the underlying mechanism is also proposed.Methods and results36 middle‐aged Sprague–Dawley rats are assigned to one of the diets containing soybean oil, lard, or fish oil (4%). The rats are fed for 5 weeks and then goblet cells, Muc2 expression, and inflammatory cytokines in the colon are measured. Proteome analysis is performed. Compared with the lard and soybean oil diet groups, intake of fish oil decreases the number of goblet cells, and inhibits Muc2 and TLRs expression in the colon of middle‐aged rats, which would impair mucus barrier. Several key enzymes involved in glycosylation process, including Agr2, Gale, Gne, Pmm2, Pdxdc1, Plch1, Pfkp, Cmpk1, and Rexo2, show the lowest abundance in the fish oil diet group.ConclusionIntake of fish oil at a normal dose downregulates colonic Muc2 expression. This negative effect of fish oil may involve the suppression of mucin glycosylation process.

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Section: Discussioncontrasting

confidence: 52%

Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle‐Aged Rats by Suppressing the Glycosylation Process

Zhou

Li³

et al. 2018

Molecular Nutrition Food Res

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“…Palmitoleic acid and conjugated linoleic acid may prevent fat deposition in the liver 26, 27 . Furthermore, intake of DHA and arachidonic acid (ARA) can significantly reduce hepatic weight, serum TAG and TC, epididymal fat as compared to palmitic acid, which would be associated with enhanced fatty acid β-oxidation, down-regulated mRNA fatty acid synthase and sterol regulatory element binding protein-1c expression 28 . And thus, intake of long-chain saturated fatty acids (the number of carbon skeletons greater than 12) may increase lipid deposition, while monounsaturated or polyunsaturated fatty acids would inhibit lipid deposition.…”

Section: Discussionmentioning

confidence: 99%

Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats

Fan

et al. 2017

Sci Rep

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The impact of dietary soybean oil, lard and fish oil on physiological responses in middle age is little studied. In this study, we investigated the changes of oxidative stress, inflammatory cytokines, telomere length, and age-related gene expression in the liver of middle-aged rats in response to the above three fat diets. Male Sprague Dawley rats (12 months old) were fed AIN-93M diets for 3 months, in which soybean oil was equivalently replaced by lard or fish oil. As compared to the lard diet, intake of fish oil diet significantly decreased body weight gain, white blood cell count, and levels of hepatic triacylglycerol, total cholesterol, fat accumulation, low-density lipoprotein, oxidative stress and inflammatory cytokines (P < 0.05), but increased telomere length (P < 0.05). On the other hand, lard diet and soybean oil diet showed great similarity in the above variables. PCR array analysis further indicated that fish oil diet significantly down-regulated gene expression related to inflammatory response, apoptosis, DNA binding, proteostasis and telomere attrition. Differentially expressed genes were enriched in the complement and coagulation cascades pathways. Such physiological and molecular responses could be due to different fatty acid composition in fish oil, lard and soybean oil.

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“…A study evaluated the effects of diets rich in palmitic acid supplemented with DHA or ALA oil on the microbiota of rats [ 109 ]. They observed that the diet with an addition of 10% ALA by weight was responsible for an increase in the content of Lactobacillus and Allobaculum , which are species responsible for improving intestinal health and promoting the production of SCFA.…”

Section: Inflammatory Process and Intestinal Microbiotamentioning

confidence: 99%

“…They observed that the diet with an addition of 10% ALA by weight was responsible for an increase in the content of Lactobacillus and Allobaculum , which are species responsible for improving intestinal health and promoting the production of SCFA. These SCFAs increased their concentrations by 41.9% when compared to the group that received only palmitic acid [ 109 ].…”

Section: Inflammatory Process and Intestinal Microbiotamentioning

confidence: 99%

Fatty Acids Consumption: The Role Metabolic Aspects Involved in Obesity and Its Associated Disorders

et al. 2017

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Obesity and its associated disorders, such as insulin resistance, dyslipidemia, metabolic inflammation, dysbiosis, and non-alcoholic hepatic steatosis, are involved in several molecular and inflammatory mechanisms that alter the metabolism. Food habit changes, such as the quality of fatty acids in the diet, are proposed to treat and prevent these disorders. Some studies demonstrated that saturated fatty acids (SFA) are considered detrimental for treating these disorders. A high fat diet rich in palmitic acid, a SFA, is associated with lower insulin sensitivity and it may also increase atherosclerosis parameters. On the other hand, a high intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids may promote positive effects, especially on triglyceride levels and increased high-density lipoprotein (HDL) levels. Moreover, polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs) are effective at limiting the hepatic steatosis process through a series of biochemical events, such as reducing the markers of non-alcoholic hepatic steatosis, increasing the gene expression of lipid metabolism, decreasing lipogenic activity, and releasing adiponectin. This current review shows that the consumption of unsaturated fatty acids, MUFA, and PUFA, and especially EPA and DHA, which can be applied as food supplements, may promote effects on glucose and lipid metabolism, as well as on metabolic inflammation, gut microbiota, and hepatic metabolism.

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The impact of dietary sn-2 palmitic triacylglycerols in combination with docosahexaenoic acid or arachidonic acid on lipid metabolism and host faecal microbiota composition in Sprague Dawley rats

Cited by 30 publications

References 49 publications

Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle‐Aged Rats by Suppressing the Glycosylation Process

Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle‐Aged Rats by Suppressing the Glycosylation Process

Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats

Fatty Acids Consumption: The Role Metabolic Aspects Involved in Obesity and Its Associated Disorders

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