The impact of dietary protein intake on longevity and metabolic health

Kitada, Munehiro; Ogura, Yoshio; Monno, Itaru; Koya, Daisuke

doi:10.1016/j.ebiom.2019.04.005

Cited by 114 publications

(89 citation statements)

References 100 publications

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“…HYD also partially rescued delayed pupariation and eclosion in Spen-KD animals (Figure 2, D and G and Table 2), but it became detrimental to the longevity of both male and mated female Spen-KD adults (Figure 3, A and D and Table 3). This is in accordance with previous data suggesting a high-protein diet has negative longitudinal effects on life span (Kitada et al 2019). Conversely, CTRL-KD mated female and male life spans were not significantly affected by HYD ( Figure 3, A and D and Table 3).…”

Section: Discussionsupporting

confidence: 93%

“…HSD partially rescues the early death of Spen-KD flies Just as defects in metabolism can lead to delays in development, so can they lead to longevity defects (Lushchak et al 2012;Kitada et al 2019). Since Spen-KD flies displayed defects in development during the larval stage in conjunction with the larval fat phenotype on the control MYD, we asked whether there was a long-term effect on the life span of adult flies.…”

Section: Hsds and Hyds Partially Rescue Previously Characterized Devementioning

confidence: 99%

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Gene–Diet Interactions: Dietary Rescue of Metabolic Defects in spen-Depleted Drosophila melanogaster

et al. 2020

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Obesity and its comorbidities are a growing health epidemic. Interactions between genetic background, the environment, and behavior (i.e., diet) greatly influence organismal energy balance. Previously, we described obesogenic mutations in the gene Split ends (Spen) in Drosophila melanogaster, and roles for Spen in fat storage and metabolic state. Lipid catabolism is impaired in Spen-deficient fat storage cells, accompanied by a compensatory increase in glycolytic flux and protein catabolism. Here, we investigate gene–diet interactions to determine if diets supplemented with specific macronutrients can rescue metabolic dysfunction in Spen-depleted animals. We show that a high-yeast diet partially rescues adiposity and developmental defects. High sugar partially improves developmental timing as well as longevity of mated females. Gene–diet interactions were heavily influenced by developmental-stage-specific organismal needs: extra yeast provides benefits early in development (larval stages) but becomes detrimental in adulthood. High sugar confers benefits to Spen-depleted animals at both larval and adult stages, with the caveat of increased adiposity. A high-fat diet is detrimental according to all tested criteria, regardless of genotype. Whereas Spen depletion influenced phenotypic responses to supplemented diets, diet was the dominant factor in directing the whole-organism steady-state metabolome. Obesity is a complex disease of genetic, environmental, and behavioral inputs. Our results show that diet customization can ameliorate metabolic dysfunction underpinned by a genetic factor.

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Section: Discussionsupporting

confidence: 93%

Section: Hsds and Hyds Partially Rescue Previously Characterized Devementioning

confidence: 99%

Gene–Diet Interactions: Dietary Rescue of Metabolic Defects in spen-Depleted Drosophila melanogaster

et al. 2020

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“…We postulate 511 that the increase in protein is insufficient to counteract the "starvation" effect caused by 512 immobilized lipid stores, which are critical mediators of cell growth and division by 513 Table 3). 523 This is in accordance with previous data suggesting a high protein diet has negative 524 longitudinal impacts on lifespan (Kitada et al 2019). Conversely, CTRL-KD mated 525 female and male lifespans are unaffected by HYD ( Figure 3A, D, Table 3).…”

Section: Discussion 391supporting

confidence: 87%

Gene-diet interactions: dietary rescue of metabolic defects inspen-depleted Drosophila

Gillette

Hazegh

Nemkov

et al. 2019

Preprint

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20Obesity and its co-morbidities are a growing health epidemic. Interactions between 21 genetic background and the environment and behavior (i.e. diet) greatly influence 22 organismal energy balance. Previously, we described obesogenic mutations in the 23 gene Split ends (Spen) in Drosophila melanogaster, and roles for Spen in fat storage 24 and metabolic state. In Spen-deficient storage cells lipid catabolism is impaired, 25 accompanied by a compensatory increase in glycolytic flux and protein catabolism. 26Here we investigate gene-diet interactions to determine if diets supplemented with 27 specific macronutrients can rescue metabolic dysfunction in Spen-depleted animals. We 28show that a high-yeast diet partially rescues adiposity and developmental defects. High 29 sugar partially improves developmental timing as well as adult longevity. Gene-diet 30 interactions were heavily influenced by developmental-stage-specific organismal needs: 31 extra yeast provides benefits early in development (larval stages) but becomes 32 detrimental in adulthood. High sugar confers benefits at both larval and adult stages, 33 with the caveat of increased adiposity. A high-fat diet is detrimental according to all 34 tested criteria, regardless of genotype. Whereas Spen depletion influenced phenotypic 35 responses to supplemented diets, diet was the dominant factor in directing the whole-36 organism steady-state metabolome. Obesity is a complex disease of genetic, 37 environmental, and behavioral inputs. Our results show that diet customization can 38 ameloriate metabolic dysfunction underpinned by a genetic factor. 39 utilization of nutrients (catabolism) to nutrient storage (anabolism). 50While diet can be a major driver of fat storage, gene-environment interactions 51 play a critical yet poorly understood role in the development of obesity and metabolic 52 syndrome, defined as "clustering of abdominal obesity, dyslipidemia, hyperglycemia and 53 hypertension" (Giovannucci 2007). Decades ago, the increased incidence of Diabetes 54Mellitus was attributed to an evolutionarily beneficial 'thrifty' genotype that is 55 incompatible with the modern Western Diet and lifestyle (Neel 1962). Evidence of 56 genetic adaptation to a diet high in polyunsaturated fatty acids can be found in the 57 genomes of Greenlandic Inuit, in the form of genetic variants in fatty acid desaturases 58 (Fumagalli et al. 2015;Chen et al. 2019). Accordingly, developing a comprehensive 59 understanding of obesity and metabolic syndrome demands examination of the interplay 60 between genetics and diet. 61Drosophila melanogaster is an excellent model in which to study gene function in 62 metabolism (Grönke et al. 2003(Grönke et al. , 2005Baker and Thummel 2007; Leopold and 63 Perrimon 2007;Schlegel and Stainier 2007;Guo et al. 2008;Beller et al. 2010; Reis et 64 al. 2010;Hazegh et al. 2017;Musselman and Kuhnlein 2018). Metabolic pathways are 65 highly conserved in Drosophila (Bernards and Hariharan 2001) and many fat regulatory 66 genes have functional orthol...

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“…On Okinawa Island, higher daily intake of green and yellow vegetables and meat contributed to longevity [45]. However, red meat contains high levels of methionine, and higher intake of animal protein may promote diseases [46]. Thus, balanced nutrition and proper protein intake are essential, and consumption of white meat about once a month is desirable, similar to the consumption among the oldest old aged 95 to 108 in this study.…”

Section: Meat Intakementioning

confidence: 69%

WITHDRAWN: Impact of Traits and Quality of Life on Longevity Among Those Aged 95 to 108  

Kim

Choi

Kim

2020

Preprint

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BackgroundThe crucial differences in longevity related to quality of life and specific traits in the oldest old need to be investigated from a socioecological perspective because their impacts may differ in the oldest-old adults. This entailed estimating the impacts of quality of life and personal traits on the longevity of the oldest old in South Korea from a socioecological perspective. MethodsThe data were obtained from interviews with 170 South Koreans aged 95 to 108 from June 2017 to February 2020. Specifically, we interviewed 130 residents aged 100 to 108 and 40 aged 95 to 99 across 36 provinces in South Korea. This study incorporated an analytical model to observe the effects that were distributed across individuals, societies, and countries from a socioecological perspective. The factor analyses of the interview responses revealed significant correlations and hierarchical models.ResultsSeven factors were identified as major to quality of life and traits, and five in particular, industriousness, physical labour, weight 60kg, friends, meat intake, affected their longevity. In addition, fewer feelings of depression or anxiety and higher life satisfaction and living standards also influenced the longevity. ConclusionsThe quality of life and traits of South Korea’s oldest old appear to have a decisive latent impact on longevity factors. We identified seven crucial determinants of longevity in the oldest old: industriousness, labour, weight, friends, and meat intake, fewer feelings of depression or anxiety, and higher life satisfaction. Thus, those who seek longevity might emulate these traits of the oldest old.

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The impact of dietary protein intake on longevity and metabolic health

Cited by 114 publications

References 100 publications

Gene–Diet Interactions: Dietary Rescue of Metabolic Defects in spen-Depleted Drosophila melanogaster

Gene–Diet Interactions: Dietary Rescue of Metabolic Defects in spen-Depleted Drosophila melanogaster

Gene-diet interactions: dietary rescue of metabolic defects inspen-depleted Drosophila

WITHDRAWN: Impact of Traits and Quality of Life on Longevity Among Those Aged 95 to 108

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The impact of dietary protein intake on longevity and metabolic health

Cited by 114 publications

References 100 publications

Gene–Diet Interactions: Dietary Rescue of Metabolic Defects in spen-Depleted Drosophila melanogaster

Gene–Diet Interactions: Dietary Rescue of Metabolic Defects in spen-Depleted Drosophila melanogaster

Gene-diet interactions: dietary rescue of metabolic defects inspen-depleted Drosophila

WITHDRAWN: Impact of Traits and Quality of Life on Longevity Among Those Aged 95 to 108&nbsp;&nbsp;

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WITHDRAWN: Impact of Traits and Quality of Life on Longevity Among Those Aged 95 to 108