The impact of dietary oestrogens on male and female fertility

West, Mhairi C L

doi:10.1097/gco.0b013e3280e129ba

Cited by 8 publications

(3 citation statements)

References 69 publications

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“…Indeed, it was demonstrated that isoflavones adversely affect the reproductive organ development and cause bleeding in male animals [ 12 – 13 ] . Chavarro et al explained that ingestion of soybean foods renders the isoflavones to interrupt the activity of body hormones stimulating spermatogenesis, leading to a decrease in sperm number [ 14 ] .…”

Section: Introductionmentioning

confidence: 99%

Effects of a soybean milk product on feto-neonatal development in rats

Park

Ban

et al. 2018

J Biomed Res

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Since estrogenic pollutants and phytoestrogens can cause the disorder of the reproductive system, the effects of a soybean milk product (Vegemil® containing 162 ppm isoflavones) on the feto-neonatal development, including male reproductive function, were investigated. Pregnant rats were fed the soybean milk (5% or 100% in drinking water) from gestational day (GD) 6 to parturition or to post-natal day (PND) 56. Specifically, the rats were divided into 4 groups: the control group (drinking water), the GD5% group (5% soybean milk during only the GD period), the GD-PND5% group (5% soybean milk during the GD and PND periods), and the GD-PND100% group (100% soybean milk instead of water during the GD and PND periods). During the gestational, lactational, and developmental periods, the reproductive and developmental parameters of dams and offspring were observed. Feeding soybean milk did not affect the birth and physical development of both male and female offspring. At PND57, the weights of the testes and epididymides of F1 males significantly increased by feeding a high concentration of the soybean milk (GD-PND100%). In addition, feeding of the soybean milk during both the GD and PND periods (GD-PND5% and GD-PND100%) enhanced the sperm counts and motility. The results indicate that soybean milk is safe for embryos, fetuses, and offspring, and improves the post-generational development of male reproductive function.

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Section: Introductionmentioning

confidence: 99%

Effects of a soybean milk product on feto-neonatal development in rats

Park

Ban

et al. 2018

J Biomed Res

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“…For example, the effect on the hypothalamic-pituitary-testosterone axis has been shown to cause compensated hypogonadism [67]. Also, the effect on fertility in males of reproductive age is a rising concern [83]. Kumar et al [84] did a 12 week randomized, interventional study with daily supplementation of 80 mg of oral purified isoflavone/day versus placebo in men with early prostate cancer (n=53), and reported no clinical toxicity from the drug.…”

Section: Discussionmentioning

confidence: 99%

Phytoestrogens and their Potential Role in Prostate Cancer Prevention and Treatment

Kolukula¹

2011

J Cancer Sci Ther

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Phytoestrogens are hormonally active compounds present in plant foods that are being studied extensively for their potential roles in hormonally-sensitive neoplasms such as prostate cancer. We postulate that the evidence for a protective role of phytoestrogens is not conclusive enough for a general recommendation for their use as dietary supplements, but phytoestrogens can be considered for therapeutic use in prostate cancer patients under certain circumstances. A literature review was performed to study the evidence regarding the chemopreventive role of phytoestrogens in healthy men, the protective role in early prostate cancer, and a possible therapeutic role in advanced prostate cancer patients. Dietary supplementation with phytoestrogens for chemoprevention of prostate cancer is still a debatable subject. Numerous pre-clinical in vitro studies have been promising, and novel molecular mechanisms of action for phytoestrogens continue to be identified. However, human clinical trials including studies done on prostate biomarkers and on the effects of phytoestrogens on steroid hormones are complicated by the possibility of local paracrine effects in prostatic tissue by phytoestrogens that are steroid-like in structure. Their interaction with multiple enzymes represents a paradigm for the complexity of phytoestrogen effects and a window into a potential reason that study results are inconsistent or difficult to explain. A final outcome of the phytoestrogen effect in the intact human may be difficult to discern because these agents can inhibit or induce enzymes, destroy cancer cells, yet will have intrinsic estrogenic effects themselves. Larger multi-center, multi-national, randomized controlled trials are needed before definitive recommendations can be made on the usefulness of phytoestrogens for chemoprevention and therapy for prostate cancer. However, combinations of phytoestrogens with radiation therapy and other antioxidants in advanced or metastatic prostate cancer can be considered because there are limited effective therapy options for this group of patients.

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“…Des investigations approfondies sur la responsabilité de ces perturbations endocriniennes quant à la baisse de la production spermatique ou de malformations congénitales sont actuellement en cours d'analyse (Bhatia, 2005) et de nombreuses expérimentations in vivo et in vitro démontrent effectivement que certains produits chimiques rejetés dans l'environnement ont des effets délétères sur la reproduction (Jobling & Tyler, 2006 ;Longnecker et al, 2003). Parmi les agents susceptibles d'induire des effets nocifs sur la fonction reproductive, on peut citer les produits d'origine anthropique, comme les glycoéthers (Multigner et al, 2005), les pesticides organochlorés (Oliva et al, 2001), et ceux d'origine naturelle comme les phyto-oestrogènes ou les produits de combustion (West, 2007). Cependant, le manque de connaissance sur les voies de signalisation de ces perturbations, les niveaux d'expositions des espèces et les risques encourus suscitent un intense effort de recherche de la part de la communauté scientifique pour élucider les mécanismes à l'origine de ses dysfonctions.…”

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Évolution, spermatozoïde et fertilité

Joly

2008

J. Soc. Biol.

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The impact of dietary oestrogens on male and female fertility

Cited by 8 publications

References 69 publications

Effects of a soybean milk product on feto-neonatal development in rats

Effects of a soybean milk product on feto-neonatal development in rats

Phytoestrogens and their Potential Role in Prostate Cancer Prevention and Treatment

Évolution, spermatozoïde et fertilité

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