The impact of dietary habits on the pathogenesis of rheumatoid arthritis: a case-control study

Rambod, Masoume; Nazarinia, Mohammad Ali; Raieskarimian, Farahnaz

doi:10.1007/s10067-018-4151-x

Cited by 31 publications

(41 citation statements)

References 23 publications

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“…It is well known that patients with RA commonly have iron deficiency 43 44. Rambod et al have demonstrated a number of significant differences between the diets of patients with RA and control subjects and it is possible that the significant differences in Cd levels reported here in the patients with RA could represent differences in diets and this would be subject to further research 45…”

Section: Discussionmentioning

confidence: 74%

Prevalence of rheumatoid arthritis in relation to serum cadmium concentrations: cross-sectional study using Korean National Health and Nutrition Examination Survey (KNHANES) data

et al. 2019

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ObjectivesIt has been suggested that exposure to heavy metal cadmium (Cd) may contribute to a high risk of developing rheumatoid arthritis (RA). This study was to investigate the association of RA prevalence and serum concentrations of Cd and other heavy metals through large survey data analysis.DesignA retrospective cross-sectional survey study.SettingLarge population survey in Korea.Participants53 829 subjects participated in Korean National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2013.InterventionsHeavy metals were measured in different time periods of the survey programme which resulted in three different data sets for analysis: Cd, mercury (Hg) and lead (Pb) from 2008 to 2012 survey; serum manganese (Mn) and urine arsenic (As) from 2008 to 2009 survey; and serum zinc (Zn) from 2010 survey. RA prevalence and its associations with serum heavy metals were analysed using a general linear/logistic regression model of complex sample design.ResultsSerum Cd was elevated in patients with RA (RA vs control: 1.30±0.07 µg/L vs 1.17±0.01 µg/L, p<0.01). There were no significant differences in urine levels of As or serum levels of Pb, Hg, Mn or Zn between patients with RA and controls. OR (95% CI) of RA prevalence according to 1 µg/L increase of serum Cd level was 1.28(95% CI 1.03 to 1.61). Prevalence of RA in women was increased with increasing quartiles of Cd levels, with a 19-fold difference in female RA prevalence between individuals in the lowest quartile of serum Cd level and those in the highest quartile (0.18% vs 3.42%). Cubic spline curve of prevalence OR showed increased risk of RA according to increased serum Cd level. Increased risk of RA in men was not observed with increased serum Cd levels.ConclusionThere was an increased prevalence of RA in females associated with increased serum levels of Cd in the Korean population.

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Section: Discussionmentioning

confidence: 74%

Prevalence of rheumatoid arthritis in relation to serum cadmium concentrations: cross-sectional study using Korean National Health and Nutrition Examination Survey (KNHANES) data

et al. 2019

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“…Finally, there have been multiple studies detailing the effects of green tea consumption in RA patients and reduction in disease activity score-28 (DAS28) as well as better pain management. Moreover, green tea was shown to prevent RA more effectively when compared with high fat beverages [ 122 ].…”

Section: The Use Of Plant Natural Products For Arthritis Therapymentioning

confidence: 99%

Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome

Dudics

Langan

Meka

et al. 2018

IJMS

122

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Rheumatoid arthritis (RA) is a chronic, debilitating illness characterized by painful swelling of the joints, inflammation of the synovial lining of the joints, and damage to cartilage and bone. Several anti-inflammatory and disease-modifying drugs are available for RA therapy. However, the prolonged use of these drugs is associated with severe side effects. Furthermore, these drugs are effective only in a proportion of RA patients. Hence, there is a need to search for new therapeutic agents that are effective yet safe. Interestingly, a variety of herbs and other natural products offer a vast resource for such anti-arthritic agents. We discuss here the basic features of RA pathogenesis; the commonly used animal models of RA; the mainstream drugs used for RA; the use of well-characterized natural products possessing anti-arthritic activity; the application of nanoparticles for efficient delivery of such products; and the interplay between dietary products and the host microbiome for maintenance of health and disease induction. We believe that with several advances in the past decade in the characterization and functional studies of natural products, the stage is set for widespread clinical testing and/or use of these products for the treatment of RA and other diseases.

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“…By grouping the tea consumption into 3 levels, we found that the negative relation between tea and DAS28-ESR happened in a dose-response manner (p for trend < 0.01). A previous study has reported that RA development and intake of green tea are negatively associated [9]. However, this study focused only on the correlation between green tea and RA development, and it did not pay attention to the quantity of tea and the disease activity.…”

Section: Discussionmentioning

confidence: 99%

“…In many studies, it was found that consuming tea was associated with a reduced risk of mortality, oral cancer and psychological distress [7,8]. More recently, it has been shown that green tea might have preventive effects on the development of RA (OR 0.65, CI 0.45-0.93) [9]. Another small-scale clinical trial showed that RA patients treated with green tea for 6 months alone or in combination with infliximab had significant improvement in disease activity [10].…”

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confidence: 99%

Tea Consumption Is Associated with Decreased Disease Activity of Rheumatoid Arthritis in a Real-World, Large-Scale Study

Jin¹,

Li²,

Gan³

et al. 2020

Ann Nutr Metab

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Introduction: The role of tea consumption on rheumatoid arthritis (RA) has been studied in recent years, but no clear conclusion has been drawn as a result of small sample size of the studies or the fact that only in vitro studies have been performed. Objectives: The aim of this study was to explore the possible association of tea consumption with RA through a large-scale, real-world study. Methods: A total of 733 RA patients were investigated from June to December, 2016. The disease activity of RA was assessed according to disease activity score 28-erythrocyte sedimentation rate. The amount and types of tea consumption were recorded by on-site self-administered questionnaires. Logistic regression models were applied to analyze the correlation between tea consumption and disease activity, adjusting for demographics, clinical and laboratory factors. Results: There was an inverse association between tea consumption and disease activity in RA patients (OR 0.66, 95% CI 0.46–0.94). Compared with non-tea drinkers, a higher-intake of tea (>750 mL/day) was associated with lower disease activity of RA (OR 0.39, 95% CI 0.19–0.79), but not low-intake (≤750 mL/day; OR 0.83, 95% CI 0.42–1.63). A significant dose-response association was found between the amount of tea consumption and disease activity (p for trend <0.01). Further hierarchical regression analysis showed that such inverse associations were mainly present in female patients (p = 0.004), non-smokers (p = 0.01) or elders (≥60 years; p = 0.01). Conclusion: Tea consumption is associated with decreased disease activity of RA, suggesting the potential beneficial effect of tea in the disease.

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The impact of dietary habits on the pathogenesis of rheumatoid arthritis: a case-control study

Cited by 31 publications

References 23 publications

Prevalence of rheumatoid arthritis in relation to serum cadmium concentrations: cross-sectional study using Korean National Health and Nutrition Examination Survey (KNHANES) data

Prevalence of rheumatoid arthritis in relation to serum cadmium concentrations: cross-sectional study using Korean National Health and Nutrition Examination Survey (KNHANES) data

Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome

Tea Consumption Is Associated with Decreased Disease Activity of Rheumatoid Arthritis in a Real-World, Large-Scale Study

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