The Impact of Diet and Exercise on Drug Responses

Niederberger, Ellen; Parnham, Michael J.

doi:10.3390/ijms22147692

Cited by 27 publications

(20 citation statements)

References 178 publications

(196 reference statements)

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“…3,20 Those inhibitory effects can be further amplified by dietary habits, lifestyle, and specific metabolism, accumulation, and elimination rates. 34 For instance, the accumulation and risk of adverse DDIs with toxic chemicals that occur in meat and dairy products might be lower than the average in vegan and vegetarian populations, but higher in communities that rely on them as primary food sources.…”

Section: Articlementioning

confidence: 99%

TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters

Michel,

Wen,

Yee

et al. 2023

Clin Pharma and Therapeutics

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Environmental health science seeks to predict how environmental toxins, chemical toxicants, and prescription drugs accumulate and interact within the body. Xenobiotic transporters of the ATP‐binding Cassette (ABC) and solute carrier (SLC) superfamilies are major determinants of the uptake and disposition of xenobiotics across the kingdoms of life. The goal of this study was to integrate drug and environmental chemical interactions (DECIs) of mammalian ABC and SLC proteins in a centralized, integrative database. We built upon an existing publicly accessible platform – the “TransPortal” – which was updated with novel data and searchable features on transporter‐interfering chemicals (TICs) from manually curated literature data. The integrated resource TransPortal‐TICBase (https://transportal.compbio.ucsf.edu) now contains information on 46 different mammalian xenobiotic transporters of the ABC‐ and SLC‐type superfamilies, including 13 newly added rodent and two additional human drug transporters, 126 clinical drug‐drug interactions (DDIs), and a more than quadrupled expansion of the initial in vitro chemical interaction data from 1402 to 6296 total interactions. Based on our updated database, environmental interference with major human and rodent drug transporters occurs across the ABC‐ and SLC‐type superfamilies, with kinetics indicating that some chemicals, such as the ionic liquid 1‐hexylpyridinium chloride and the antiseptic chlorhexidine, can act as strong inhibitors with potencies similar or even higher than pharmacological model inhibitors. The new integrated web portal serves as a central repository of current and emerging data for interactions of prescription drugs and environmental chemicals with human drug transporters. This archive has important implications for predicting adverse drug‐drug and drug‐environmental chemical interactions and can serve as a reference website for the broader scientific community of clinicians and researchers.

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Section: Articlementioning

confidence: 99%

TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters

Michel,

Wen,

Yee

et al. 2023

Clin Pharma and Therapeutics

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“…The physiological consequences of exercise and diet include changes in drug efficacy and toxicity. 189 For instance, a recent metagenomic and transcriptomic study shows that recovery from a dysbiosis-inducing therapy (ie, antibiotics) is also very much dependent on dietary management. 190 Interestingly, just as the diet habits can affect gut health, the alteration of the microbiome may also affect eating habits which is linked with the SCFA metabolism.…”

Section: Dysbiosis and Cardiovascular Diseasesmentioning

confidence: 99%

Impact of the Gastrointestinal Tract Microbiota on Cardiovascular Health and Pathophysiology

Akyıldız

Biondi-Zoccai

Biase

2022

Journal of Cardiovascular Pharmacology

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:The microbiota of the gastrointestinal tract (GIT) is an extremely diverse community of microorganisms, and their collective genomes (microbiome) provide a vast arsenal of biological activities, particularly enzymatic ones, which are far from being fully elucidated. The study of the microbiota (and the microbiome) is receiving great interest from the biomedical community because it carries the potential to improve risk prediction models, refine primary and secondary prevention efforts, and also design more appropriate and personalized therapies, including pharmacological ones. A growing body of evidence, although sometimes impaired by the limited number of subjects involved in the studies, suggests that GIT dysbiosis, that is, the altered microbial composition, has an important role in causing and/or worsening cardiovascular disease (CVD). Bacterial translocation and the alteration of levels of microbe-derived metabolites can thus be important to monitor and modulate because they may lead to initiation and progression of CVD and to its establishment as chronic state. We hereby aim to provide readers with details on available resources and experimental approaches that are used in this fascinating field of biomedical research and on some novelties on the impact of GIT microbiota on CVD.

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“…"Several studies have shown that diet and body composition as well as exercise are lifestyle components that can influence many components of drug metabolism and efficacy. Patients are often not aware of the potential risk factors, which are particularly important if drugs with a narrow therapeutic range/window are used" [69]. "Physiological adaptations to acute and chronic exercise are such that there is good reason to suspect that exercise has the potential to significantly influence drug absorption and bioavailability, drug distribution within the body, and drug elimination from the body.…”

Section: Sino-nasalmentioning

confidence: 99%

Exercise Performance and Immune Competence [EPIC]: Background of Natural Immunity, Immune Diversity and Immuno-iatrogenesis

Rajkumar¹

2022

IJPR

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Impeccable Metabolic Maneuvers Upbring Natural Immunity To You [IMMUNITY]. Homeostatic competence of human body is an output of meticulous and interdependent/integrated/impeccable metabolic functions to resist or overcome diseases and facilitate a lengthy lifespan along the healthy ageing trajectory. Principles of homeostasis are seldom employed in the clinical applications. Perhaps this has led to almost an irreparable derailment of ethics and core competence of medical profession. Ivan Dominic Illich emphasized his criticisms on iatrogenesis and argued that modern medicine had hubristically taken on a mission to eradicate pain, sickness, even death but expropriated the autonomous power of humans to cope with their ailments. It is also quite obvious that the medical profession has failed to learn about ‘healthy individuals’ elaborately. Healthy individuals possess quintessential epigenetic efficiency and homeostatic competence built through several years of disciplined lifestyle, and especially their fitness characteristics are incomparably superior to individuals who never or rarely display propensity to improve their health standards. The disastrous perception of Immunology that ‘Best Homeostasis’ and ‘Worst Allostasis’ are same, hence all the individuals regardless of their health status are equally a potential source of disease transmission during an infectious disease outbreak, has caused severe disruption in various aspects of human life across the globe. Even the healthiest/fittest athletes and outstanding exercisers could asymptomatically transmit an infection to unhealthy people [who led an unhealthy lifestyle] whose disease could be anywhere in the allostasis spectrum ranging from early-stage co-morbidities to severe functional deterioration? Under the aegis of homeostasis and non-specific antibodies [Secretory IgA], a long-lasting Natural Immunity [NI] should be possible excluding the need of ‘specific antibodies’. Expanded Trained Immunity [ETI] proposed by Cassone has been found not only in innate immune system but also in nonimmune cells [both cells of hematopoietic and nonhematopoietic origin] associated with immunological memories from previous microbial encounters. Interesting discoveries about NI and ETI could emerge if they are linked with homeostasis and allostasis to develop objective immunologic tests to differentiate the healthy and unhealthy individuals, and enhance the clarity of immunology. Exercises are strongly linked to immunity; thus, measurements of exercise performance standards could accurately reveal the status of NI of the individuals if exercise performance data are systematically interpreted and correlated with immunologic function. Exercise performance data can be gathered using easily accessible non-invasive inexpensive tools. From the perspectives of homeostasis, we may not have distinct departments in the body to curb/defeat immunological or other non-immunological diseases, but any disease could be a threat to recovery to pre-existing conditions or even survival, if the homeostatic functions are impaired by iatrogenesis. KEYWORDS: Homeostasis, Innate Immunity, Adaptive Immunity, Exercise, Epigenetics, Trained Immunity, Secretory IgA, Allostasis, Immunosenescence, Iatrogenesis.

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The Impact of Diet and Exercise on Drug Responses

Cited by 27 publications

References 178 publications

TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters

TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters

Impact of the Gastrointestinal Tract Microbiota on Cardiovascular Health and Pathophysiology

Exercise Performance and Immune Competence [EPIC]: Background of Natural Immunity, Immune Diversity and Immuno-iatrogenesis

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