The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions

Yaribeygi, Habib; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

doi:10.1155/2020/5436832

Cited by 21 publications

(25 citation statements)

References 110 publications

(132 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Clinical experience indicates that people with diabetes who develop COVID-19 are more likely to develop acute metabolic decompensation, including ketoacidosis, itself associated with poorer outcomes. In keeping with the hypothesis of direct toxicity of SARS-CoV-2 to β-cells increased rates of diagnosis of type 1 diabetes have been reported (163,164).…”

Section: Diabetes and Covid-19supporting

confidence: 56%

“…Hyperglycaemia is associated with elevated levels of proinflammatory cytokines, in particular IL-6: the resultant pro-inflammatory milieu is associated with susceptibility to infection with coronaviruses (163). Moreover, associated oxidative stress facilitates entry of the virus into host cells and activation of hypoxia-inducible factor-1α, promoting rapid viral replication and the development of cytokine "storm" -a syndrome that often signals the sharp deterioration of people with COVID-19 after a few days of illness (163,164). Such pathways are now being further investigated in more detail in large cohorts, particularly PHOSP-COVID which is currently recruiting 10,000 hospitalised survivors of COVID-19 in the UK (165).…”

Section: Diabetes and Covid-19mentioning

confidence: 99%

See 1 more Smart Citation

Cardiovascular and Renal Risk Factors and Complications Associated With COVID-19

et al. 2021

View full text Add to dashboard Cite

The current COVID-19 pandemic, caused by the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome-Coronavirus-2), represents the largest medical challenge in decades. It has exposed unexpected cardiovascular vulnerabilities at all stages of the disease (pre-infection, acute phase and subsequent chronic phase). The major cardiometabolic drivers identified to have epidemiological and mechanistic associations with COVID-19 are abnormal adiposity, dysglycemia, dyslipidemia, and hypertension. Hypertension is of particular interest, because components of the renin-angiotensin system (RAS), which are critically involved in the pathophysiology of hypertension, are also implicated in COVID-19. Specifically ACE2, a multifunctional protein of the RAS, which is part of the protective axis of the RAS, is also the receptor through which SARS-CoV-2 enters host cells causing viral infection. Cardiovascular and cardiometabolic co-morbidities not only predispose to COVID-19, but are complications of SARS-CoV-2 infection. In addition, increasing evidence indicates that acute kidney injury is common in COVID-19, that it occurs early and in temporal association with respiratory failure and is associated with poor prognosis, especially in the presence of cardiovascular risk factors. Here we discuss cardiovascular and kidney disease in the context of COVID-19 and provide recent advances on putative pathophysiological mechanisms linking cardiovascular disease and COVID-19, focusing on the RAS and ACE2 as well as the immune system and inflammation. We provide up-to-date information on the relationship between hypertension, diabetes, and COVID-19 and emphasize the major cardiovascular diseases associated with COVID-19. We also briefly discuss emerging cardiovascular complications associated with long COVID-19, notably postural tachycardia syndrome (POTS).

show abstract

Section: Diabetes and Covid-19supporting

confidence: 56%

Section: Diabetes and Covid-19mentioning

confidence: 99%

Cardiovascular and Renal Risk Factors and Complications Associated With COVID-19

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Current evidence demonstrates that patients with diabetes are more likely to experience severe symptoms and complications than patients without diabetes due to COVID-19 infection. Hyperglycemia facilitates the virus entry into the cells since ACE2 and virus both need glucose for their function [ 96 ]. Patients with poorly controlled hyperglycemia have higher pro-apoptotic factors as well as apoptosis dependent cell death in kidneys, liver, lungs, and brain [ 96 ].…”

Section: Pre-exiting Condition Effect On Covid-19 Outcomementioning

confidence: 99%

“…Hyperglycemia facilitates the virus entry into the cells since ACE2 and virus both need glucose for their function [ 96 ]. Patients with poorly controlled hyperglycemia have higher pro-apoptotic factors as well as apoptosis dependent cell death in kidneys, liver, lungs, and brain [ 96 ]. Diabetic patients are prone to more severe degrees of COVID-19 infection due to their altered Renin-angiotensin-aldosterone system (RAAS) functions which facilitate viral invasion [ 96 ].…”

Section: Pre-exiting Condition Effect On Covid-19 Outcomementioning

confidence: 99%

SARS-CoV-2 Infection and Oral Health: Therapeutic Opportunities and Challenges

Coke

Davison

Fields

et al. 2021

JCM

View full text Add to dashboard Cite

The novel corona virus, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), and the disease it causes, COVID-19 (Coronavirus Disease-2019) have had multi-faceted effects on a number of lives on a global scale both directly and indirectly. A growing body of evidence suggest that COVID-19 patients experience several oral health problems such as dry mouth, mucosal blistering, mouth rash, lip necrosis, and loss of taste and smell. Periodontal disease (PD), a severe inflammatory gum disease, may worsen the symptoms associated with COVID-19. Routine dental and periodontal treatment may help decrease the symptoms of COVID-19. PD is more prevalent among patients experiencing metabolic diseases such as obesity, diabetes mellitus and cardiovascular risk. Studies have shown that these patients are highly susceptible for SARS-CoV-2 infection. Pro-inflammatory cytokines and oxidative stress known to contribute to the development of PD and other metabolic diseases are highly elevated among COVID-19 patients. Periodontal health may help to determine the severity of COVID-19 infection. Accumulating evidence shows that African-Americans (AAs) and vulnerable populations are disproportionately susceptible to PD, metabolic diseases and COVID-19 compared to other ethnicities in the United States. Dentistry and dental healthcare professionals are particularly susceptible to this virus due to the transferability via the oral cavity and the use of aerosol creating instruments that are ubiquitous in this field. In this review, we attempt to provide a comprehensive and updated source of information about SARS-CoV-2/COVID-19 and the various effects it has had on the dental profession and patients visits to dental clinics. Finally, this review is a valuable resource for the management of oral hygiene and reduction of the severity of infection.

show abstract

“…Studies have found a relationship between diabetes and increased severity and mortality of coronavirus disease [91] , [92] , [93] . Several studies have observed increased cellular adaptive stress and thrombotic tendency due to insulin inactivity that may lead to vascular complications and heart failure which can be intensified by lung dysfunction after COVID-19 infection [91] , [94] , [95] , [96] , [97] , [98] , [99] . Nevertheless, modulation of miRNAs on cardiovascular system can serve as a therapeutic approach for patients with diabetes and COVID-19.…”

Section: Diabetes Myocardial Damage and Heart Failure And Covid-19mentioning

confidence: 99%

Role of microRNAs in COVID-19 with implications for therapeutics

Arghiani¹,

Nissan²,

Matin³

2021

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

COVID-19 is a pneumonia-like disease with highly transmittable and pathogenic properties caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infects both animals and humans. Although many efforts are currently underway to test possible therapies, there is no specific FDA approved drug against SARS-CoV-2 yet. miRNA-directed gene regulation controls the majority of biological processes. In addition, the development and progression of several human diseases are associated with dysregulation of miRNAs. In this regard, it has been shown that changes in miRNAs are linked to severity of COVID-19 especially in patients with respiratory diseases, diabetes, heart failure or kidney problems. Therefore, targeting these small noncoding-RNAs could potentially alleviate complications from COVID-19. Here, we will review the roles and importance of host and RNA virus encoded miRNAs in COVID-19 pathogenicity and immune response. Then, we focus on potential miRNA therapeutics in the patients who are at increased risk for a severe disease.

show abstract

The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions

Cited by 21 publications

References 110 publications

Cardiovascular and Renal Risk Factors and Complications Associated With COVID-19

Cardiovascular and Renal Risk Factors and Complications Associated With COVID-19

SARS-CoV-2 Infection and Oral Health: Therapeutic Opportunities and Challenges

Role of microRNAs in COVID-19 with implications for therapeutics

Contact Info

Product

Resources

About