The Impact of Dexmedetomidine-loaded Nano-microsphere Combined with Percutaneous Acupoint Electrical Stimulation on the Postoperative Cognitive Function of Elderly Patients with Hip Fracture

Wang, Shigao; Wang, Ju; Yang, Jianping

doi:10.14715/cmb/2022.68.3.10

Cited by 3 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The porous structure of microspheres facilitates cell adhesion and proliferation, making them widely applicable as cell carriers in irregular tissue defect repair. Based on their structure, microspheres can be classified into porous microspheres, bilayer microspheres, and magnetic microspheres, which can be prepared through methods such as emulsification and evaporation, phase separation, spray drying, and hot-melt extrusion [ 132 , 133 ]. By encapsulating BPNS with antibacterial and photothermal effects within microspheres, not only can the material’s mechanical strength and porosity be enhanced, but the drug release behavior can also be modulated, bacterial growth can be inhibited, and tissue regeneration can be regulated.…”

Section: Bp-based Composite Biomaterials For Tissue Repairmentioning

confidence: 99%

Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering

Qi,

Zhang,

Wang

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

Black Phosphorus (BP) is a new semiconductor material with excellent biocompatibility, degradability, and optical and electrophysical properties. A growing number of studies show that BP has high potential applications in the biomedical field. This article aims to systematically review the research progress of BP composite medical materials in the field of tissue engineering, mining BP in bone regeneration, skin repair, nerve repair, inflammation, treatment methods, and the application mechanism. Furthermore, the paper discusses the shortcomings and future recommendations related to the development of BP. These shortcomings include stability, photothermal conversion capacity, preparation process, and other related issues. However, despite these challenges, the utilization of BP-based medical materials holds immense promise in revolutionizing the field of tissue repair.

show abstract

Section: Bp-based Composite Biomaterials For Tissue Repairmentioning

confidence: 99%

Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering

Qi,

Zhang,

Wang

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…Based on structure, microspheres can be categorized into pore microspheres, double-layer microspheres, and magnetic microspheres. Microspheres can be prepared by emulsification and volatilization, phase separation, spray-drying, and hot melt extrusion [ 243 - 246 ]. 1.…”

Section: Biomaterials Used In Tumor Immunotherapymentioning

confidence: 99%

Emerging biomaterials for tumor immunotherapy

et al. 2023

View full text Add to dashboard Cite

Background The immune system interacts with cancer cells in various intricate ways that can protect the individual from overproliferation of cancer cells; however, these interactions can also lead to malignancy. There has been a dramatic increase in the application of cancer immunotherapy in the last decade. However, low immunogenicity, poor specificity, weak presentation efficiency, and off-target side effects still limit its widespread application. Fortunately, advanced biomaterials effectively contribute immunotherapy and play an important role in cancer treatment, making it a research hotspot in the biomedical field. Main body This review discusses immunotherapies and the development of related biomaterials for application in the field. The review first summarizes the various types of tumor immunotherapy applicable in clinical practice as well as their underlying mechanisms. Further, it focuses on the types of biomaterials applied in immunotherapy and related research on metal nanomaterials, silicon nanoparticles, carbon nanotubes, polymer nanoparticles, and cell membrane nanocarriers. Moreover, we introduce the preparation and processing technologies of these biomaterials (liposomes, microspheres, microneedles, and hydrogels) and summarize their mechanisms when applied to tumor immunotherapy. Finally, we discuss future advancements and shortcomings related to the application of biomaterials in tumor immunotherapy. Conclusion Research on biomaterial-based tumor immunotherapy is booming; however, several challenges remain to be overcome to transition from experimental research to clinical application. Biomaterials have been optimized continuously and nanotechnology has achieved continuous progression, ensuring the development of more efficient biomaterials, thereby providing a platform and opportunity for breakthroughs in tumor immunotherapy. Graphical Abstract

show abstract

“…Postoperative cognitive function (POCD) is common in elderly stroke patients and manifests as cognitive decline in various aspects such as memory, language, understanding, thinking or attention [1]. Existing studies have proven that risk factors such as older age, low education level, and preoperative mental health can promote the occurrence of POCD [2].…”

Section: Introductionmentioning

confidence: 99%

Sirtuin 3 (SIRT3) improves sevoflurane-induced postoperative cognitive impairment by regulating mitochondrial oxidative stress

Changzong Dai,

Changquan Fu,

Zhiguo Yi

et al. 2024

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

One of the most prevalent co-operative disorders is postoperative cognitive dysfunction (POCD), however, its pathogenesis remains unclear. Thus, this work aimed to evaluate SIRT3's impact on cognitive decline in aged mice under anesthesia. Adeno-associated virus SIRT3 vector (AAV-SIRT3) or empty vector (AAV-VEH) was injected into the hippocampal region of aged mice after sevoflurane induction in order to upregulate the expression of SIRT3. The expression levels of SIRT3, pro-inflammatory cytokines, and apoptotic factors in hippocampus tissues were identified by PCR, Western blotting, TUNEL staining, and enzyme-linked immunosorbent assay (ELISA), and the cognitive function of mice was assessed. The SIRT3 expression was downregulated in the hippocampal tissue of anesthetized mice. SIRT3 overexpression can improve the learning and memory ability, reduce the escape latency, and increase the residence time in the platform and platform crossing ability of mice. The overexpression of SIRT3 in hippocampus can reduce the oxidative stress response and inflammatory response induced by anesthesia in mice, increase the superoxide dismutase (SOD) expression level, and decrease the expression level of MDA and inflammatory factors in hippocampus. In addition, SIRT3 overexpression can also reduce anesthetic-induced hippocampal cell apoptosis. By reducing the hippocampus mitochondrial oxidative stress response, SIRT3 plays a significant role in the pathophysiology of POCD in mice and is a potential target for POCD treatment and diagnosis.

show abstract

The Impact of Dexmedetomidine-loaded Nano-microsphere Combined with Percutaneous Acupoint Electrical Stimulation on the Postoperative Cognitive Function of Elderly Patients with Hip Fracture

Cited by 3 publications

References 22 publications

Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering

Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering

Emerging biomaterials for tumor immunotherapy

Sirtuin 3 (SIRT3) improves sevoflurane-induced postoperative cognitive impairment by regulating mitochondrial oxidative stress

Contact Info

Product

Resources

About