The impact of craving and impulsivity on aggression in detoxified cocaine-dependent patients

Roozen, Hendrik G.; Kroft, Petra van der; Marle, Hjalmar J. van; Franken, Ingmar H.A.

doi:10.1016/j.jsat.2010.12.003

Cited by 39 publications

(29 citation statements)

References 37 publications

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“…The finding that specific subscales of the DDQ-C and OCDUS-C were associated with the amount of money spent on drugs, whereas other subscales and the VACS scale were not, could be taken as a further demonstration of the superiority of a multidimensional craving questionnaire. Finally, our results concur with previous studies showing both the OCDUS-C and DDQ-C demonstrate concurrent validity, which has previously been shown through associations with impulsivity (27), attentional bias for cocaine cues (15), cocaine use 3 months after treatment (28), reductions in grey matter volume in the orbitofrontal cortex (indicating lack of top-down control) (29), cue reactivity (30), and larger amplitudes on ERP waves (P3/LPP) for cocaine-related stimuli (31,32). The DDQ-cocaine factor ''control'' was the only factor that did not correlate significantly with the VACS and with the number of days patients used cocaine in the month before admittance.…”

Section: Discussionsupporting

confidence: 93%

“…Hence, the OCDUS and DDQ are both multidimensional, short-to-administer measures of cocaine craving that may be valuable adjuncts to currently available measures. Although both versions are already quite frequently used to measure craving for cocaine in laboratory settings (15,(27)(28)(29)(30)(31)(32), no research report can be found that has subjected the cocaine versions of the OCDUS and DDQ to a thorough psychometric evaluation.…”

Section: Introductionmentioning

confidence: 99%

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Validation of the cocaine versions of the Obsessive Compulsive Drug Use Scale and the Desires for Drug Questionnaire

Lievaart

Erciyes

Veen

et al. 2015

The American Journal of Drug and Alcohol Abuse

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Our results indicate that the OCDUS and DDQ for cocaine are both easy to administer and reliable instruments to assist the clinical practitioner or researcher to measure craving in cocaine dependent subjects. Moreover, the factor structure for the cocaine versions were similar to the heroin versions, indicating the OCDUS and the DDQ can be reliably used to measure craving for both substances, enabling a direct comparison between heroin and cocaine craving.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Validation of the cocaine versions of the Obsessive Compulsive Drug Use Scale and the Desires for Drug Questionnaire

Lievaart

Erciyes

Veen

et al. 2015

The American Journal of Drug and Alcohol Abuse

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“…Substance-dependent inpatients with pathologic dissociation had higher scores on the AQ when compared to nondissociative patients (Evren et al, 2013). Inpatient detoxified cocaine-dependent patients had elevated levels of aggression compared to a control group as measured by the AQ (Roozen et al, 2011). …”

Section: Aggression and Adhdmentioning

confidence: 99%

Attention Deficit Hyperactivity Disorder, Aggression, and Illicit Stimulant Use

Odell

Reynolds

Fisher³

et al. 2017

J Nerv Ment Dis

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This study compares adults with and without ADHD on measures of direct and displaced aggression and illicit drug use. Three hundred ninety-six adults were administered the Wender Utah Rating Scale, the Risk Behavior Assessment, the Aggression Questionnaire (AQ), and the Displaced Aggression Questionnaire (DAQ). Those with ADHD were higher on all scales of the AQ and DAQ, were younger at first use of amphetamines, and were more likely to have ever used crack, and amphetamines. An SEM found a significant interaction in that for those with medium and high levels of verbal aggression, ADHD predicts crack and amphetamine. Follow-up logistic regression models suggest that Blacks self-medicate with crack and Whites and Hispanics self-medicate with amphetamine when they have ADHD and verbal aggression.

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“…This study also revealed that aggression was not necessarily related to cocaine craving, but was associated with the presence of antisocial personality disorder. On the other hand, craving was positively correlated with both impulsivity and aggression (Roozen et al, 2011). Specifically, patients with high impulsivity exhibit both high craving and high aggression levels (Roozen et al, 2011).…”

Section: Neurobiological and Behavioral Consequences Of Long-term mentioning

confidence: 99%

Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: Focus on dopamine, norepinephrine and glutamate

Haile

Mahoney

Newton

et al. 2012

Pharmacology & Therapeutics

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Much effort has been devoted to research focused on pharmacotherapies for cocaine dependence yet there are no FDA-approved medications for this brain disease. Preclinical models have been essential to defining the central and peripheral effects produced by cocaine. Recent evidence suggests that cocaine exerts its reinforcing effects by acting on multiple neurotransmitter systems within mesocorticolimibic circuitry. Imaging studies in cocaine-dependent individuals have identified deficiencies in dopaminergic signaling primarily localized to corticolimbic areas. In addition to dysregulated striatal dopamine, norepinephrine and glutamate are also altered in cocaine dependence. In this review, we present these brain abnormalities as therapeutic targets for the treatment of cocaine dependence. We then survey promising medications that exert their therapeutic effects by presumably ameliorating these brain deficiencies. Correcting neurochemical deficits in cocaine-dependent individuals improves memory and impulse control, and reduces drug craving that may decrease cocaine use. We hypothesize that using medications aimed at reversing known neurochemical imbalances is likely to be more productive than current approaches. This view is also consistent with treatment paradigms used in neuropsychiatry and general medicine.

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The impact of craving and impulsivity on aggression in detoxified cocaine-dependent patients

Cited by 39 publications

References 37 publications

Validation of the cocaine versions of the Obsessive Compulsive Drug Use Scale and the Desires for Drug Questionnaire

Validation of the cocaine versions of the Obsessive Compulsive Drug Use Scale and the Desires for Drug Questionnaire

Attention Deficit Hyperactivity Disorder, Aggression, and Illicit Stimulant Use

Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: Focus on dopamine, norepinephrine and glutamate

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