Filipinos' public expression of their religious practices was restricted by the government during the COVID-19 pandemic as a means to limit the spread of the virus. As a traditionally religious people, this may have added to the mental and emotional burdens particularly of the youth. This study sought to ascertain the relationship between religiosity and spirituality and self-reported symptoms of depression among college students of a particular university in Antipolo City, Philippines. 86 volunteers who publicly profess a specific religious affiliation and who belong to families whose parents are both living were selected to be the participants of this study. The Religiosity and Spirituality Scale for Youth was utilized as well as the PHQ-9 instrument of Pfizer to measure the respondents' levels of self-reported depressive symptoms. It was found that females exhibited higher religiosity and spirituality than the males. Females also exhibited higher levels of self-reported depressive symptoms than males. Respondents whose parents are staying together exhibited higher religiosity and spirituality than those whose parents are separated and respondents whose parents are separated exhibited higher levels of self-reported depressive symptoms than those whose parents are staying together. The respondents without romantic involvement exhibited higher religiosity and spirituality than those with romantic involvement and respondents without romantic involvement exhibited higher levels of self-reported depressive symptoms than those with romantic involvement. A low negative relationship between Religiosity and Spirituality Scale scores and PHQ-9 scores of the respondents was established. This finding implies that higher levels of religiosity and spirituality tend to lower the incidence of mental health issues such as depression among the respondents of this study.