This chapter investigates the unique challenges faced by Women of Color (WOC) in professional environments through the lens of intersectional invisibility and the Job Demands-Resources (JD-R) model. Intersectional invisibility highlights the compounded marginalization experienced by WOC, leading to both hypervisibility and invisibility in the workplace. The chapter delves into the psychological and physical impacts of increased job demands, such as microaggressions and selective incivility, and their effects on mental health, stress, and burnout. It explores strategies for WOC to mitigate these demands and emphasizes the crucial role of organizational support, including inclusive leadership, equitable policies, and supportive work environments. The significance of mentorship and networking opportunities for career advancement is also discussed. The chapter concludes with practical implications for organizations and future research directions, advocating for systemic changes to foster more inclusive and equitable workplaces.