The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study

Tanaçan, Atakan; Yazıhan, Nuray; Erol, Seyit Ahmet; Anuk, Ali Taner; Yetiskin, Fatma Didem Yucel; Biriken, Derya; Özgü-Erdinç, A. Seval; Keskin, Hüseyin Levent; Tekın, Özlem Moraloğlu; Şahın, Dilek

doi:10.1016/j.cyto.2021.155431

Cited by 62 publications

(66 citation statements)

References 38 publications

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“…In animal models of MIA, both viral exposure and direct injection of IL-6 lead to dose-dependent atypical behavior in offspring 44,45 . Although SARS-CoV-2 severity during pregnancy is positively correlated with IL-6 levels 43 , our analysis did not reveal an association between severity and ASQ-3 scores. It should be noted that the majority of our Fisher's Exact Tests were one-sided to test whether a greater proportion of infants in the pandemic cohort met the ASQ-3 cutoffs compared to infants in the historical cohort.…”

Section: Discussioncontrasting

confidence: 87%

“…Despite little evidence that coronaviruses, such as SARS-CoV, MERS-CoV, and now SARS-CoV-2, can cross the placenta 41,42 , the speculation that in utero SARS-CoV-2 exposure may impact infant neurobehavior was based on the established role of MIA on fetal brain development and fueled by recent findings of increased interleukin-6 (IL-6) in SARS-CoV-2-infected pregnant women 43 . In animal models of MIA, both viral exposure and direct injection of IL-6 lead to dose-dependent atypical behavior in offspring 44,45 .…”

Section: Discussionmentioning

confidence: 99%

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Birth during the COVID-19 pandemic, but not maternal SARS-CoV-2 infection during pregnancy, is associated with lower neurodevelopmental scores at 6-months

Shuffrey

Firestein

Kyle

et al. 2021

Preprint

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The intrauterine environment strongly influences development. Neurodevelopmental effects of in utero exposure to maternal SARS-CoV-2 infection are widely speculated but currently unknown. The COVID-19 Mother Baby Outcomes (COMBO) initiative was established at Columbia University Irving Medical Center (CUIMC) in New York City to prospectively study the health and wellbeing of infants with and without in utero exposure to maternal SARS-CoV-2 infection. We report findings on 6-month neurodevelopmental outcomes using the parental-report Ages & Stages Questionnaire, 3rd Edition (ASQ-3), from 107 in utero exposed and 131 unexposed full-term infants born between March and December, 2020. We compare these infants to a historical cohort comprised of 62 infants born at CUIMC at least two months prior to the onset of the pandemic. In utero exposure to maternal SARS-CoV-2 infection was not associated with differences on any ASQ-3 subdomain regardless of infection timing or severity, however, infants born during the pandemic had significantly lower scores on gross motor, fine motor, and personal-social subdomains when compared to the historical cohort. Infants born to women who were in the first trimester of pregnancy during the peak of the pandemic in NYC had the lowest personal-social scores. Birth during the pandemic, but not maternal SARS-CoV-2 infection, was associated with differences in neurodevelopmental outcomes at 6-months. These early findings suggest significantly higher public health impact for the generation born during the COVID-19 pandemic than previously anticipated.

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Section: Discussioncontrasting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Birth during the COVID-19 pandemic, but not maternal SARS-CoV-2 infection during pregnancy, is associated with lower neurodevelopmental scores at 6-months

Shuffrey

Firestein

Kyle

et al. 2021

Preprint

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“…Stage III is the most severe stage, which manifests as an extrapulmonary systemic hyper inflammation syndrome, driven by the cytokine storm. Stage III is characterized by exuberant inflammation resulting from high circulating cytokines such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) [7][8][9][10][11][12]. These inflammatory mediators are responsible for the multi-organ damage, including acute respiratory distress syndrome (ARDS) and cardiac and renal dysfunction [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Assessment of the Antiviral Activity of Ketotifen, Indomethacin and Naproxen, Alone and in Combination, against SARS-CoV-2

Kiani

Scholey

Dahl³

et al. 2021

Viruses

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The 2019 coronavirus infectious disease (COVID-19) is caused by infection with the new severe acute respiratory syndrome coronavirus (SARS-CoV-2). Currently, the treatment options for COVID-19 are limited. The purpose of the experiments presented here was to investigate the effectiveness of ketotifen, naproxen and indomethacin, alone or in combination, in reducing SARS-CoV-2 replication. In addition, the cytotoxicity of the drugs was evaluated. The findings showed that the combination of ketotifen with indomethacin (SJP-002C) or naproxen both reduce viral yield. Compared to ketotifen alone (60% inhibition at EC50), an increase in percentage inhibition of SARS-CoV-2 to 79%, 83% and 93% was found when co-administered with 25, 50 and 100 μM indomethacin, respectively. Compared to ketotifen alone, an increase in percentage inhibition of SARS-CoV-2 to 68%, 68% and 92% was found when co-administered with 25, 50 and 100 μM naproxen, respectively. For both drug combinations the observations suggest an additive or synergistic effect, compared to administering the drugs alone. No cytotoxic effects were observed for the administered dosages of ketotifen, naproxen, and indomethacin. Further research is warranted to investigate the efficacy of the combination of ketotifen with indomethacin (SJP-002C) or naproxen in the treatment of SARS-CoV-2 infection in humans.

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“…In a study identified in Turkey, maternal infection with COVID-19 increases the rate of pregnancy complications (miscarriage, preterm delivery) [ 8 ]. Evidence suggests that elevated levels of inflammatory cytokines during infection with COVID-19 and changes in the balance of inflammatory and anti-inflammatory cytokines in pregnant women can cause pregnancy complications [ 9 ]. Though information is not enough on clinical features and neonatal outcomes in pregnant women with COVID-19, we assessed short-term outcomes (4 weeks after discharge) and symptoms among neonates born to mothers infected with COVID-19 at the end of the first regional peak of the outbreak.…”

Section: Introductionmentioning

confidence: 99%

Neonatal Outcomes in Pregnant Women Infected with COVID-19 in Babol, North of Iran: A Retrospective Study with Short-Term Follow-Up

Rad

Mojaveri

Bouzari

et al. 2021

Infectious Diseases in Obstetrics and Gynecology

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During the coronavirus disease 2019 (COVID-19) pandemic, the number of pregnant women and neonates suffering from COVID-19 increased. However, there is a lack of evidence on clinical characteristics and neonatal outcomes in pregnant women with COVID-19. We evaluated short-term outcomes (4 weeks postdischarge) and symptoms in neonates born to mothers infected with COVID-19. In this retrospective cohort study, we included all neonates born to pregnant women with COVID-19 admitted to Ayatollah Rohani Hospital, Babol, Iran, from February 10 to May 20, 2020. Clinical features, treatments, and neonatal outcomes were measured. Eight neonates were included in the current study. The mean gestational age and birth weight of newborns were 37 ± 3.19 weeks (30₊6-40) and 3077.50 ± 697.64 gr (1720-3900), respectively. Apgar score of the first and fifth minutes in all neonates was ≥8 and ≥9 out of 10, respectively. The most clinical presentations in symptomatic neonates were respiratory distress, tachypnea, vomiting, and feeding intolerance. This manifestation and high levels of serum C-reactive protein (CRP) in three infants are common in neonatal sepsis. The blood culture in all of them was negative. They have been successfully treated with our standard treatment. Our pregnant women showed a pattern of clinical characteristics and laboratory results similar to those described for nonpregnant COVID-19 infection. This study found no evidence of intrauterine or peripartum transmission of COVID-19 from mother to her child. Furthermore, the long-term outcomes of neonates need more study.

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The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study

Cited by 62 publications

References 38 publications

Birth during the COVID-19 pandemic, but not maternal SARS-CoV-2 infection during pregnancy, is associated with lower neurodevelopmental scores at 6-months

Birth during the COVID-19 pandemic, but not maternal SARS-CoV-2 infection during pregnancy, is associated with lower neurodevelopmental scores at 6-months

In Vitro Assessment of the Antiviral Activity of Ketotifen, Indomethacin and Naproxen, Alone and in Combination, against SARS-CoV-2

Neonatal Outcomes in Pregnant Women Infected with COVID-19 in Babol, North of Iran: A Retrospective Study with Short-Term Follow-Up

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