The Impact of COVID-19 in Bone Metabolism: Basic and Clinical
                    Aspects

Tsourdi, Elena; Hofbauer, Lorenz C.; Rauner, Martina

doi:10.1055/a-1825-9641

Cited by 5 publications

(5 citation statements)

References 115 publications

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“…During the pandemic, a substantial drop in the treatment of apparent osteoporosis and adherence to medication has been seen, thereby increasing the likelihood of non-traumatic fractures due to further bone demineralization [24]. The overall reduction in medical consultations during the pandemic has led to significant delays and decreases in the diagnosis and treatment of osteoporosis [25]. Additionally, the COVID-19 infection has been linked to a loss of trabecular mass through overexpression of osteoclasts, as seen in mouse models [26].…”

Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 on Fracture Incidence in Germany: A Comparative Age and Gender Analysis of Pre- and Post-Outbreak Periods

et al. 2023

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In March 2020, Germany imposed a nationwide lockdown to curb the spread of COVID-19, prompting questions about the impact on the incidence of common fractures. This study examined 15 fracture types in pre-outbreak (2010–2019) and post-outbreak (2020–2021) periods, using data categorized by age (18–64 years, >65 years) and sex (male, female). Linear regression assessed annual growth rates, and mean fracture numbers were compared across periods for significant differences. Results indicated a positive correlation between fracture incidence rates and time for various types, such as cervical, thoracic, lumbar, and pelvic spine fractures, rib fractures, femoral neck, pertrochanteric femur, femoral shaft, and ankle fractures. Frequencies of proximal humerus, distal radius, femoral neck, pertrochanteric femur, femoral shaft, and ankle fractures in 2020 and 2021 were within predicted ranges from previous years. However, rib fractures and spinal fractures (cervical, thoracic, lumbar, and pelvic spine) occurred less frequently during this time. Notably, this study found a consistent decline in most fracture types for individuals aged 18–64 after the pandemic’s onset, while the fracture incidence of hip fractures, often referred to as fragility fractures, for those over 65 remained unchanged. Fibula fractures showed the most considerable decrease in both age groups. In conclusion, the COVID-19 pandemic substantially impacted fracture incidence, with lower rates among individuals under 65 and unchanged fragility fractures in the elderly population.

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Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 on Fracture Incidence in Germany: A Comparative Age and Gender Analysis of Pre- and Post-Outbreak Periods

et al. 2023

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“…2,3 These patients have been associated with low serum calcium levels 4 and decreased bone mineral density. 5 It has been suggested that the effects of COVID-19 on bone metabolism may negatively affect the osteointegration of dental implants. 2,3 Dental implant failures are classified as late or early failures based on the time of occurrence.…”

Section: Introductionmentioning

confidence: 99%

“…When coronavirus interferes with the ACE‐2 receptor, it changes the osteoclast/osteoblast balance in favor of osteoclasts, leading to bone resorption 2,3 . These patients have been associated with low serum calcium levels 4 and decreased bone mineral density 5 . It has been suggested that the effects of COVID‐19 on bone metabolism may negatively affect the osteointegration of dental implants 2,3 …”

Section: Introductionmentioning

confidence: 99%

COVID‐19 as a factor associated with early dental implant failures: A retrospective analysis

Sezer

Soylu

2023

Clin Implant Dent Rel Res

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ObjectivesTo analyze the effect of COVID‐19 on early implant failures and identify potential risk factors for early implant failure, concerning patient‐ and implant‐related factors.Materials and MethodsThis retrospective study is based on 1228 patients who received 4841 implants between March 11, 2020, and April 01, 2022, at Erciyes University Faculty of Dentistry. COVID‐19, age and gender of patients, smoking, diabetes, irradiation, chemotherapy, osteoporosis, the implant system, location, and characteristics of implants were recorded. At the implant level, univariate and multivariate generalized estimating equation (GEE) logistic regression was used to examine the effect of explanatory variables on early implant failure.ResultsThe early implant failure rate was 3.1% at the implant level and 10.4% at the patient level. Smokers showed a significantly higher incidence of early implant failures compared to nonsmokers. (odds ratio (OR; 95% CI): 2.140 (1.438–3.184); p < 0.001). Short implants (≤8 mm) had a higher risk of early implant failure than long implants (≥12 mm) (OR (95% CI): 2.089 (1.290–3.382); p = 0.003).ConclusionsCOVID‐19 had no significant effect on early implant failure. Smoking and short implants were associated with a higher risk for early implant failures.

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“…In past studies, scientists had suggested that the development of osteoporosis is not directly related to pneumonia. However, many studies indicated that bone metabolism disorder, bone mineral density decreasing, and bone microarchitecture destruction occurred in patients infected with SARS-CoV2 during the last 3 years of the COVID-19 pandemic ( Mi et al, 2021 ; Tsourdi et al, 2022 ). COVID-19 increased the fragility of bone tissue and the risk of fractures with increasing severity ( Battisti et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Osteoporosis in Patients With Respiratory Diseases

Qiu

Zhou

2022

Front. Physiol.

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Climate change, environmental pollution, and virus epidemics have sharply increased the number of patients suffering from respiratory diseases in recent years. Prolonged periods of illness and drug use increase the occurrence of complications in these patients. Osteoporosis is the common bone metabolism disease with respiratory disturbance, which affects prognosis and increases mortality of patients. The problem of osteoporosis in patients with respiratory diseases needs more attention. In this review, we concluded the characteristics of osteoporosis in some respiratory diseases including COPD, asthma, COVID-19, tuberculosis, and lung cancer. We revealed that hypoxia was the common pathogenesis of osteoporosis secondary to respiratory diseases, with malnutrition and corticosteroid abuse driving the progression of osteoporosis. Hypoxia-induced ROS accumulation and activated HIF-1α lead to attenuated osteogenesis and enhanced osteoclastogenesis in patients with respiratory diseases. Tuberculosis and cancer also invaded bone tissue and reduced bone strength by direct infiltration. For the treatment of osteoporosis in respiratory patients, oral-optimized bisphosphonates were the best treatment modality. Vitamin D was a necessary supplement, both for calcium absorption in osteogenesis and for improvement of respiratory lesions. Reasonable adjustment of the dose and course of corticosteroids according to the etiology and condition of patients is beneficial to prevent the occurrence and development of osteoporosis. Additionally, HIF-1α was a potential target for the treatment of osteoporosis in respiratory patients, which could be activated under hypoxia condition and involved in the process of bone remodeling.

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The Impact of COVID-19 in Bone Metabolism: Basic and Clinical Aspects

Cited by 5 publications

References 115 publications

Impact of COVID-19 on Fracture Incidence in Germany: A Comparative Age and Gender Analysis of Pre- and Post-Outbreak Periods

Impact of COVID-19 on Fracture Incidence in Germany: A Comparative Age and Gender Analysis of Pre- and Post-Outbreak Periods

COVID‐19 as a factor associated with early dental implant failures: A retrospective analysis

Osteoporosis in Patients With Respiratory Diseases

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