The Impact of Contrast-Associated Acute Kidney Injury on All-Cause Mortality in Older Patients After Coronary Angiography:A 7.5-year Follow-Up

Abstract

Older patients (≥75 years) after coronary angiography constitute an increasing proportion, but only limited data are available regarding the prognosis of geriatric contrast-associated acute kidney injury (CA-AKI). Patients (≥75 years) undergoing coronary angiography between December 2010 and September 2013 were consecutively enrolled. CA-AKI was defined as an increase in serum creatinine of 25% or .5 mg/dL from the baseline within 48–72 h of contrast exposure. All-cause mortality was assessed during median 7.5 years (interquartile range [IQR] 6.7–8.7 years) follow-up period. In total, 571 patients aged >75 years undergoing coronary angiography were enrolled in a single center study; 82 (14.4%) patients had CA-AKI. The all-cause mortality during the median 7.5 years follow-up period was 22.0% in patients with CA-AKI and 13.1% in patients without CA-AKI (P = .015). After adjusting for potential confounding factors, the multivariable analysis indicated that CA-AKI was related to an increased risk of all-cause mortality during the median 7.5-year follow-up (hazard ratio [HR]: 2.46; 95% CI: 1.29–4.7; P = .006). CA-AKI is a significant and independent predictor of long-term mortality for patients aged over 75 years who underwent coronary angiography.

The Effect of Acute Kidney Injury in Elderly Patients Undergoing Percutaneous Coronary Intervention

“…The emergence of acute kidney injury after percutaneous coronary intervention is most common in people suffering from co-morbidities like diabetes mellitus, chronic hypertension, and asthma (Mosenye et al, 2023). On the other hand, the presentation of the disease is getting more diverse in older people, with their decreased ability to tolerate the impacts of AKI given birth to the need for more intensive measures directed toward the prevention and management of the disease (Guo et al, 2023). In Pakistan, data relevant to the prevalence, incidence, and impacts of acute coronary injury after percutaneous coronary intervention is very limited (Ammar et al, 2022).…”