The impact of contact lenses on meibomian gland morphology

Osae, Eugene Appenteng; Jones, Lyndon; Nichols, Jason J.

doi:10.1016/j.jtos.2022.04.001

Cited by 7 publications

(6 citation statements)

References 116 publications

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“…More distorted glands have been reported in children with allergic conjunctivitis ( 2 , 3 ). Gland loss and tortuosity have also been reported in association with long-term contact lens wear ( 19 ). In our study, gland distortion was observed in 6.92% of children aged 10–20 years.…”

Section: Discussionmentioning

confidence: 99%

Morphologic variants of Meibomian glands: age-wise distribution and differences between upper and lower eyelids

Srivastav,

Hasnat Ali,

Basu

et al. 2023

Front. Med.

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PurposeTo evaluate the distribution of various Meibomian gland morphologies across different age groups in healthy individuals.MethodsThe infrared meibographic morphologies of the Meibomian glands from the upper and lower eyelids of 236 healthy individuals (472 eyes; mean age 38.4 ± 17.5 years; 80 female participants: 156 male participants) were evaluated for their prevalence and differences across six decades of life, from 10 to 80 years. A linear mixed-effects modeling test was performed for statistical analysis.ResultsOf 14,452 glands, 8,830 (61%) glands were located in the upper eyelid. No significant differences in frequency were noted between different age groups for distorted, tortuous, hooked, overlapping, abnormal gap, fluffy areas, dropout (except for 51–60 vs. 10–20 years, P = 0.023), and thick and thin morphologies. Short glands were significantly more common in individuals aged over 30 years (P = 0.015), whereas moderately short and severely short glands were more common in the upper eyelids of individuals older than 50 years compared to those aged 10–20 years (P = 0.035). The frequency of distorted, hooked, tortuous, overlapping, and tadpole-shaped Meibomian glands was significantly higher in the upper eyelids than in the lower eyelids for all age groups. Dropout glands were more common in the lower eyelids of individuals younger than 50 years, but no difference was observed in the upper and lower eyelids of individuals over 50 years. Dropout (P = 0.006) and severely short glands (0.026) of the lower eyelid were associated with low non-invasive tear break-up time (NIBUT) values.ConclusionVarious morphologic characteristics of the Meibomian glands that are considered abnormal can be present in healthy individuals, and only moderate to severely short glands display an increase in abnormal morphologic characteristics of the Meibomian glands with age.

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Section: Discussionmentioning

confidence: 99%

Morphologic variants of Meibomian glands: age-wise distribution and differences between upper and lower eyelids

Srivastav,

Hasnat Ali,

Basu

et al. 2023

Front. Med.

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“…A recent study on the samples of pterygium collected from 253 patients revealed that miRNA-145 is downregulated in this ocular surface disease, and it is inversely correlated with severity, extension, and the vascular spread of the lesion [ 33 ]. Furthermore, reports on the mutations of miRNA-184 showed its involvement in the reduction of corneal thickness, leading to keratoconus, and in the development of iris atrophy and the early formation of cataracts [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Extensive Contact Lens Wear Modulates Expression of miRNA-320 and miRNA-423-5p in the Human Corneal Epithelium: Possible Biomarkers of Corneal Health and Environmental Impact

Roszkowska,

Aguennouz,

Aragona

et al. 2024

Genes

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The identification of new biomarkers of ocular diseases is nowadays of outmost importance both for early diagnosis and treatment. Epigenetics is a rapidly growing emerging area of research and its involvement in the pathophysiology of ocular disease and regulatory mechanisms is of undisputable importance for diagnostic purposes. Environmental changes may impact the ocular surface, and the knowledge of induced epigenetic changes might help to elucidate the mechanisms of ocular surface disorders. In this pilot study, we investigated the impact of extensive contact lens (CL) wearing on human corneal epithelium epigenetics. We performed ex vivo analysis of the expression of the miR-320 and miR-423-5p involved in the processes of cellular apoptosis and chronic inflammation. The human corneal epithelium was harvested from healthy patients before the photorefractive keratectomy (PRK). The patients were divided into two age- and sex-matched groups accordingly to CL wearing history with no CL wearers used as a control. The epithelium was stored frozen in dry ice at −80 °C and forwarded for miRNA extraction; afterwards, miRNA levels were detected using real-time PCR. Both miRNAs were highly expressed in CL wearers (p < 0.001), suggesting epigenetic modifications occurring in chronic ocular surface stress. These preliminary results show the relationships between selected miRNA expression and the chronic ocular surface stress associated with extensive CL use. MicroRNAs might be considered as biomarkers for the diagnosis of ocular surface conditions and the impact of environmental factors on ocular surface epigenetic. Furthermore, they might be considered as new therapeutic targets in ocular surface diseases.

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“…47 Additionally, MG changes have been associated with contact lens wear; the duration of contact lens wear has been significantly correlated to MG morphological and functional changes that become apparent within the first two years of lens wear. 45,[48][49][50][51] The Medmont Meridia Professional model uses infrared light to image the MG, and uses an integrated grading scale (Meiboscale) to grade the findings (Figure 14). 27,43,[52][53][54] In addition to the meiboscale, a variety of other grading scales are integrated into the Meridia software system to grade the various captured images (see Figures 9,10 and 14).…”

Section: Dry Eye Assessment Toolsmentioning

confidence: 99%

Medmont Meridia™: Much More Than a Corneal Topographer

Fadel

2023

OPTO

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In recent years, advanced diagnostic instruments have become widely available in optometric practices, offering various functions that optimize clinical information gathering. This article focuses on the Medmont Meridia™, a state-of-the-art multipurpose diagnostic device with corneal topography and cutting-edge features. Corneal topography is pivotal in the early diagnosis of corneal disorders, determining baseline ocular surface assessment, helping in contact lens fitting, and monitoring ocular health over time. The Medmont Meridia boasts Placido-disc-based imaging with extensive corneal coverage. Furthermore, the Meridia accurately measures the horizontal visible iris diameter, pupil diameter, and palpebral fissure width, which assists in making contact lens parameter decisions. Additionally, it offers sagittal height data for scleral lens design and first lens selection, streamlining the fitting process. Beyond its topography capabilities, the Meridia excels as a comprehensive dry eye assessment tool. With features like tear meniscus height, tear film surface quality, and meibography capabilities, it aids in diagnosing dry eye and monitoring its progression. The device also provides customizable dry eye reports with integrated grading scales and questionnaires, making dry eye management, patient education, and compliance more accessible. In conclusion, the Medmont Meridia consolidates a multitude of examination tools in a single instrument, enhancing practice efficiency and elevating patient care and communication. Its versatility and accuracy make it an invaluable asset in optometric practices worldwide.

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The impact of contact lenses on meibomian gland morphology

Cited by 7 publications

References 116 publications

Morphologic variants of Meibomian glands: age-wise distribution and differences between upper and lower eyelids

Morphologic variants of Meibomian glands: age-wise distribution and differences between upper and lower eyelids

Extensive Contact Lens Wear Modulates Expression of miRNA-320 and miRNA-423-5p in the Human Corneal Epithelium: Possible Biomarkers of Corneal Health and Environmental Impact

Medmont Meridia™: Much More Than a Corneal Topographer

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