The Impact of Concurrency of Colchicine and Simvastatin on Variation of Serum Immunoglobulins IgG, IgE, IgM and IgA in Mustard Gas-Wounded Patients

Abstract

Mustard gas as a chemical weapon causes devastating effects on different tissues of the body and there is no perfect antidote against it. This gas is a very strong and nonspecific alkaline agent that is capable of causing inflammation as well as increase of immunoglobulins in the patients. This gas causes irreparable and sever damage to all the body tissues; so finding of effective medicines to treat the mustard gas-exposed patients is of great importance and is the main purpose of this study. This study was conducted as double-blind intervention during 2 months. The population society was consisted of 40 mustard gas-wounded patients. Their illness had previously been approved by Foundation of Oppressed and the Crippled and other valid government agencies. These patients were referred as OPD for treatment to pulmonary clinic related to Shiraz University of Medical Sciences (Motahari, Imam Reza and Shahid Faghihi Clinics). The studied patients in this study were divided into two groups: 1-The placebo group that included 20 patients who did not receive colchicine and simvastatin. 2-The medication group included 20 patients who received simultaneously colchicine and simvastatin with daily dosage of 1 mg/d and 10 mg/d, respectively. Then blood samples were obtained from the under studied patients and the concentration of serum immunoglobulins IgG, IgE, IgM and IgA was measured by PFT method and using Prestige 24i automate analyzer device in before and after the beginning of the treatment. The results showed that there is no significant relationship between the concentrations of IgG, IgE, IgM and IgA before and after receiving the medicines and placebo (p value: 1). The obtained results from this study indicates that both colchicine and simvastatin are not effective in patients with mustard gas toxicity and thereby it will be possible to cut the treatment with both medicines in these patients and to reduce by this way the costs related to the treatment of these patients and to ignore the continues of an useless treatment.

The Effect of Atrovastatin on Inflammatory Markers in Sulfur Mustard Gas Induced Bronchitis; A Randomized Double-Blinded, Placebo-Controlled Clinical Trial

“…Many studies had previously shown the anti-in ammatory effect of statin (23,24), but few studies could not demonstrate this effect (25,26). Considering the signi cant reduction in serum cholesterol level in Atorvastatin group it is unlikely that poor adherence to the study protocol could explain the failure to reach statistical difference between groups.…”

The effect of atorvastatin on inflammatory markers in sulfur mustard gas induced bronchitis: a randomized double-blinded, placebo-control clinical trial

“…In one hand, several studies could show the anti-inflammatory effect of statin [ 26 , 27 ]; however, few could not [ 28 , 29 ]. Considering the significant reduction in serum cholesterol level in the atorvastatin group, it is unlikely that poor adherence to the study protocol was the reason for the failure to reach statistical differences between groups.…”

The effect of atorvastatin on inflammatory markers in sulfur mustard gas induced bronchitis; a randomized double-blinded, placebo-control clinical trial

“…In one hand, several studies could show the anti-in ammatory effect of statin (26,27); however, few could not (28,29). Considering the signi cant reduction in serum cholesterol level in the atorvastatin group, it is unlikely that poor adherence to the study protocol was the reason for the failure to reach statistical differences between groups.…”