The impact of comorbid depression–diabetes on proteomic outcomes among community-dwelling Mexican Americans with mild cognitive impairment

Johnson, Leigh; Zhang, Fan; Large, Stephanie; Hall, James; O'Bryant, Sidney

doi:10.1017/s1041610219001625

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…Elevated white blood cell count, associated with increased WMH, is an indication of an increased systemic inflammatory state, which has been associated with neuroinflammation and white matter injury 18 . We found recently that diabetes was associated with an inflammatory proteomic profile among this HABLE cohort 19 . In the present study, inflammation related to diabetes did not account for this association, as increased WBC and HbA1C were both independent predictors of increased WMH volume.…”

Section: Discussioncontrasting

confidence: 71%

“…18 We found recently that diabetes was associated with an inflammatory proteomic profile among this HABLE cohort. 19 In the present study, inflammation related to diabetes did not account for this association, as increased WBC and HbA1C were both independent predictors of increased WMH volume. Finally, reduced hematocrit was also associated with increased WMH volume.…”

Section: Discussioncontrasting

confidence: 66%

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Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non‐Hispanic Whites: The HABLE study

King

Vintimilla

Braskie

et al. 2022

Alz & Dem Diag Ass & Dis Mo

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Introduction Among vascular risk factors we hypothesized that an increased prevalence of diabetes in Hispanics would be associated with greater white matter hyperintensity (WMH) volume, which may contribute to cognitive decline. Methods A total of 1318 participants (60% female; 49% Hispanic, 51% non‐Hispanic White; age 66.2 ± 8.9 years) underwent clinical evaluation and brain magnetic resonance imaging (MRI). WMH volume associations were assessed with age, sex, and ethnicity and then with vascular risk factors in a selective regression model. Results WMH volume was greater with older age ( P < .0001), Hispanic ethnicity ( P = .02), and female sex ( P = .049). WMH volume was best predicted by age, diastolic blood pressure, hypertension history, hemoglobin A1c (HbA1c), white blood cell count, and hematocrit ( P < .01 for all). Elevated HbA1c was associated with greater WMH volume among Hispanics (parameter estimate 0.08 ± 0.02, P < .0001) but not non‐Hispanic Whites (parameter estimate 0.02 ± 0.04, P = .5). Discussion WMH volume was greater in Hispanics, which may be partly explained by increased WMH volume related to elevated HbA1c among Hispanics but not non‐Hispanic Whites.

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Section: Discussioncontrasting

confidence: 71%

Section: Discussioncontrasting

confidence: 66%

Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non‐Hispanic Whites: The HABLE study

King

Vintimilla

Braskie

et al. 2022

Alz & Dem Diag Ass & Dis Mo

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“…Our team has conducted a series of studies examining the impact of depression on cognitive outcomes among Mexican Americans ( 14 , 15 , 35 – 37 ). In a recent study, Hall et al demonstrated a significant link between plasma tau and depressive symptoms among 538 community-dwelling Mexican Americans ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Depression is differentially related to cognitive and biomarker outcomes among Mexican Americans

et al. 2022

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IntroductionDespite tremendous advancements in the research of Alzheimer’s disease (AD), Mexican Americans, who reflect 65% of the US Hispanic community, remain severely underrepresented in research. Our data demonstrate that risk factors for, and biomarkers of, AD are different among Mexican Americans as compared with non-Hispanic whites. Here, we examined the impact of depressive symptoms on cognitive and AD-relevant biomarker outcomes among the Mexican Americans.MethodsData were examined from 1,633 (852 Mexican Americans and 781 non-Hispanic whites) of the Health and Aging Brain Study–Health Disparities (HABS–HD). Depression was assessed using the Geriatric Depression Scale while cognition was measured using detailed neuropsychological testing. Plasma biomarkers of Aβ40, Aβ42, total tau, and NfL were examined in addition to MRI-based neurodegeneration. PET amyloid data were available in a subset of participants.ResultsDepressive symptoms were significantly associated with cognitive testing results among both Mexican Americans and non-Hispanic whites. However, depression was only significantly associated with cognitive outcomes and plasma biomarkers among the Mexican American APOEε4 non-carriers.DiscussionDepressive symptoms are more commonly endorsed by Mexican Americans and these symptoms are more strongly associated with cognitive and AD-biomarker outcomes among this ethnic group. However, depression scores were only related to AD outcomes among APOEε4 non-carriers within the Mexican American group. These findings can aid in the development of a population-informed precision medicine for treating and preventing cognitive loss among the Mexican Americans.

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“…The prevalence of depression among diabetic patients worldwide ranges from 19% to 22% [ 18 ], while the pooled prevalence of anxiety disorders among this population is estimated to be 28% (95% CI: 26, 31, n = 57) [ 19 ]. Among the Latine population in the US, particularly among Mexican-origin adults, the comorbidity of diabetes and depression is prevalent [ 20 , 21 , 22 ]. In three district cohorts in Texas (n = 2436), the prevalence of comorbid depressive symptoms and diabetes was found to be 5 to 12 times higher among elderly Mexican-origin individuals compared to non-Latine whites [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors Associated with Diabetes among Mexican-Origin Adults in Southern Arizona

Morales

Ingram

Sepulveda

et al. 2023

IJERPH

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Diabetes is the seventh leading cause of death in the United States, and it is particularly problematic among the Latine population. This study employed multivariable logistic regression models to examine how hypertension, depression, and sociodemographics were associated with diabetes in a cross-sectional sample of Mexican-origin adults living in three counties of Southern Arizona. The overall prevalence of diabetes from this primary care sample was 39.4%. Holding covariates at fixed values, individuals having hypertension were 2.36 (95% CI: 1.15, 4.83) times more likely to have diabetes, when compared to individuals not having hypertension. The odds of having diabetes for individuals with ≥12 years of educational attainment were 0.29 (95% CI: 0.14, 0.61) times the corresponding odds of individuals with <12 years of educational attainment. For individuals with depression, the odds of having diabetes for those who were born in Mexico and had <30 years living in the US were 0.04 (95% CI: 0, 0.42) times the corresponding odds of individuals without depression and who were born in the US. Findings suggest clinical and public health systems should be aware of the potential increased risk of diabetes among Mexican-origin adults with hypertension and lower educational attainment.

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The impact of comorbid depression–diabetes on proteomic outcomes among community-dwelling Mexican Americans with mild cognitive impairment

Cited by 6 publications

References 33 publications

Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non‐Hispanic Whites: The HABLE study

Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non‐Hispanic Whites: The HABLE study

Depression is differentially related to cognitive and biomarker outcomes among Mexican Americans

Risk Factors Associated with Diabetes among Mexican-Origin Adults in Southern Arizona

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