The impact of combined administration of paraquat and maneb on motor and non-motor functions in the rat

Tinakoua, Anass; Bouabid, Salim; Faggiani, Emilie; Deurwaerdère, Philippe De; Lakhdar-Ghazal, Nouria; Benazzouz, Abdelhamid

doi:10.1016/j.neuroscience.2015.10.021

Cited by 33 publications

(12 citation statements)

References 52 publications

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“…The exact cause of PD is not clearly understood; available scientific evidence suggests that both genetic and environmental risk factors are associated in the etiology of PD. In the laboratory, exposure of several toxicants, such as rotenone, paraquat, and 1-methyl-4-phenyl 1,2,3,6 tetrahydropyridine (MPTP), causes mitochondrial defects and leads to dopamine neuron loss in the SNc neurons [1][2][3]. Among the various dopaminergic neurotoxins used to create a PD animal model, MPTP has received much attention due to its capability to produce clinical features of PD in humans and monkeys.…”

Section: Introductionmentioning

confidence: 99%

Ellagic Acid Prevents Dopamine Neuron Degeneration from Oxidative Stress and Neuroinflammation in MPTP Model of Parkinson’s Disease

2020

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Parkinson’s disease (PD) is one of the most common neurodegenerative diseases and is characterized by progressive dopaminergic neurodegeneration in the substantia nigra pars compacta area. In the present study, treatment of EA for 1 week at a dose of 10 mg/kg body weight prior to MPTP (25 mg/kg body weight) was carried out. MPTP administration caused oxidative stress, as evidenced by decreased activities of superoxide dismutase and catalase, and the depletion of reduced glutathione with a concomitant rise in the lipid peroxidation product, malondialdehyde. It also significantly increased the pro-inflammatory cytokines and elevated the inflammatory mediators like cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in the striatum. Immunohistochemical analysis revealed a loss of dopamine neurons in the SNc area and a decrease in dopamine transporter in the striatum following MPTP administration. However, treatment with EA prior to MPTP injection significantly rescued the dopaminergic neurons and dopamine transporter. EA treatment further restored antioxidant enzymes, prevented the depletion of glutathione and inhibited lipid peroxidation, in addition to the attenuation of pro-inflammatory cytokines. EA also reduced the levels of COX-2 and iNOS. The findings of the present study demonstrate that EA protects against MPTP-induced PD and the observed neuroprotective effects can be attributed to its potent antioxidant and anti-inflammatory properties.

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Section: Introductionmentioning

confidence: 99%

Ellagic Acid Prevents Dopamine Neuron Degeneration from Oxidative Stress and Neuroinflammation in MPTP Model of Parkinson’s Disease

2020

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“…It is possible to address the effect of FPN on monoamine systems by measuring the content of the monoamines and their metabolites in various parts of the brain. It allows one to determine possible regional and quantitative alterations in the neurochemistry of monoamines at terminals in response to neurotoxins, including 1-methyl-4-phenyl-pyridinium ion (MPTP) [ 16 , 17 ], rotenone [ 18 ], 6-hydroxydopamine (6-OHDA) [ 19 ], or paraquat and maneb [ 20 ], to cite a few. However, it is noticeable that numerous studies have failed to report an effect of the full lesion of one monoaminergic system on the tissue content of the other monoamines [ 21 , 22 ], at odds with the numerous local and distal interactions these systems establish [ 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic Administration of Fipronil Heterogeneously Alters the Neurochemistry of Monoaminergic Systems in the Rat Brain

Bharatiya

Chagraoui

Deurwaerdere

et al. 2020

IJMS

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Fipronil (FPN), a widely used pesticide for agricultural and non-agricultural pest control, is possibly neurotoxic for mammals. Brain monoaminergic systems, involved in virtually all brain functions, have been shown to be sensitive to numerous pesticides. Here, we addressed the hypothesis that chronic exposure to FPN could modify brain monoamine neurochemistry. FPN (10 mg/kg) was chronically administered for 21 days through oral gavage in rats. Thereafter, the tissue concentrations of dopamine (DA) and its metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid; serotonin (5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA); and noradrenaline (NA) were measured in 30 distinct brain regions. FPN significantly decreased DA and its metabolite levels in most striatal territories, including the nucleus accumbens and the substantia nigra (SN). FPN also diminished 5-HT levels in some striatal regions and the SN. The indirect index of the turnovers, DOPAC/DA and 5-HIAA/5-HT ratios, was increased in numerous brain regions. FPN reduced the NA content only in the nucleus accumbens core. Using the Bravais–Pearson test to study the neurochemical organization of monoamines through multiple correlative analyses across the brain, we found fewer correlations for NA, DOPAC/DA, and 5-HIAA/5-HT ratios, and an altered pattern of correlations within and between monoamine systems. We therefore conclude that the chronic administration of FPN in rats induces massive and inhomogeneous changes in the DA and 5-HT systems in the brain.

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“…It normalizes gait coordination 14 , improves coordination of hand preshaping 15 and enhances gait symmetry 16 , all of which are required for gait coordination. In animals with Parkinson’s disease, changes in subthalamic activity patterns were accompanied by deficits in motor coordination 17 . In patients with traumatic brain injury 18 and older adults 19 , STN was activated less during motor coordination relative to younger healthy controls.…”

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confidence: 99%

Subthalamic Neurons Encode Both Single- and Multi-Limb Movements in Parkinson’s Disease Patients

Tankus

Strauss

Gurevich

et al. 2017

Sci Rep

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The subthalamic nucleus (STN) is the main target for neurosurgical treatment of motor signs of Parkinson’s disease (PD). Despite the therapeutic effect on both upper and lower extremities, its role in motor control and coordination and its changes in Parkinson’s disease are not fully clear. We intraoperatively recorded single unit activity in ten patients with PD who performed repetitive feet or hand movements while undergoing implantation of a deep brain stimulator. We found both distinct and overlapping representations of upper and lower extremity movement kinematics in subthalamic units and observed evidence for re-routing to a multi-limb representation that participates in limb coordination. The well-known subthalamic somatotopy showed a large overlap of feet and hand representations in the PD patients. This overlap and excessive amounts of kinematics or coordination units may reflect pathophysiology or compensatory mechanisms. Our findings thus explain, at the single neuron level, the important subthalamic role in motor control and coordination and indicate the effect of PD on the neuronal representation of movement.

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The impact of combined administration of paraquat and maneb on motor and non-motor functions in the rat

Cited by 33 publications

References 52 publications

Ellagic Acid Prevents Dopamine Neuron Degeneration from Oxidative Stress and Neuroinflammation in MPTP Model of Parkinson’s Disease

Ellagic Acid Prevents Dopamine Neuron Degeneration from Oxidative Stress and Neuroinflammation in MPTP Model of Parkinson’s Disease

Chronic Administration of Fipronil Heterogeneously Alters the Neurochemistry of Monoaminergic Systems in the Rat Brain

Subthalamic Neurons Encode Both Single- and Multi-Limb Movements in Parkinson’s Disease Patients

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