The impact of coil shape design on angiographic occlusion, packing density and coil mass uniformity in aneurysm embolization: an in vitro study

Abstract

Objective To investigate the impact of coil design on the distribution of the coil mass in a controlled in vitro experiment. A secondary objective was to study the relationship between angiographic occlusion, packing density and coil mass uniformity. Methods Seven silicon side wall aneurysm models were embolized in each arm with a different coil design under fluoroscopic guidance. Packing density calculations and scoring of the angiographic occlusion were made. The models were embedded in epoxy and sectioned through the aneurysm neck and the dome. The sections were imaged and processed to derive the fractional surface area of coil material over the coil free area, a quantitative endpoint representing the percentage of the given region of interest consumed by coils. The SD of the surface area fractions is inversely proportional to the uniformity of coil distribution. Results The novel triangular primary wind design of the Deltapaq achieved a more homogenous distribution of coils within the aneurysm dome compared with the helical and complex microcoil systems (p¼0.018). The packing density achieved by the Deltapaq (39.161.6%) was significantly higher than the complex (35.262.8%) and the helical (32.263.3%) coils. Angiographically, aneurysms coiled by the Deltapaq were more likely to obtain a Raymond score of class I. Conclusion Evaluation of emerging coil technologies with respect to treatment durability may be well served by an assessment of their uniformity of distribution within an aneurysm in addition of the traditional packing density and angiographic occlusion scoring methods.

Safety, immediate and mid-term results of the newer generation of hydrogel coils in the treatment of ruptured aneurysms: a multicenter study

“…However, when hydrocoil represented >75% or when it was the final coil placed, the rate of recurrence was significantly lower (p=0.035 and p=0.047, respectively) 11. Indeed, a more uniform hydrogel coil distribution in the aneurysm sac and, in particular, in the aneurysm neck, may be more relevant to achieving a better occlusion rates than PD as demonstrated in some in vitro studies 12 13…”

Analysis and quantification of endovascular coil distribution inside saccular aneurysms using histological images

“…In-slice coil density has recently been calculated to assess coil distribution in a similar way but in silicone coiled aneurysm models 26. In this study the authors used slices of the aneurysm dome and neck that were partitioned in angular regions to assess coil distribution.…”

A history of detachable coils: 1987–2012

“…In vitro data by Mehra et al 27 showed superior regularity in distribution within a volume relative to helical primary wind designs from the same manufacturer.…”