The Impact of Coexisting Gestational Diabetes Mellitus on the Course of Preeclampsia

Pankiewicz, Katarzyna; Szczerba, Ewa; Fijałkowska, Anna; Sierdziński, Janusz; Issat, Tadeusz; Maciejewski, T.

doi:10.3390/jcm11216390

Cited by 4 publications

(4 citation statements)

References 60 publications

(73 reference statements)

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“…First, differences in the metabolic profiles of patients with and without GDM may have affected the findings. Second, although the independent and significant associations between GDM and PE have been confirmed, the main mechanistic manifestations are completely different GDM is a proangiogenic state and PE is an antiangiogenic state [27] . This may affect the association between quercetin and these two diseases.…”

Section: Resultsmentioning

confidence: 97%

Relationship between Effect of Dietary Flavonoid Intake and Risk of Preeclampsia: A Research Study

Liu,

Kang

et al. 2023

IJPS

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Risk of Preeclampsia and Dietary Flavonoid IntakeThe purpose of this research was just to explore the connection between the risk of preeclampsia and the dietary consumption of flavonoids. This research adopted one matched case control study was devised with 1:1 matching by gestational age (±1 w), age (±3 y) as well as presence of gestational diabetes (yes/no). From March 2016 to June 2019, 440 pairs of participators in total were recruited. Information of dietary was attained with one questionnaire of 78 item semi quantitative food frequency. Dietary flavonoid intake was calculated using the residual method. Multivariate conditional logistic regression was adopted with the objective to assessing 95 % confidence intervals and the odds ratios. In comparison to the lowest intake quartiles, passive connections were surveyed between preeclampsia risk and the flavanones consumption (odds ratio=0.506, 95 % confidence interval=0.278-0.920, p=0.024), naringenin (odds ratio=0.477, 95 % confidence interval=0.266-0.853, p=0.02), luteolin (odds ratio=0.597, 95 % confidence interval=0.395-0.902, p<0.007) and quercetin (odds ratio=0.518, 95 % confidence interval=0.286-0.938, p<0.034) after adjustment for potential confounders. Consumption of total anthocyanidins, total flavan-3-ols and eight other specific flavonoids (hesperetin, apigenin, isorhamnetin, kaempferol, myricetin, daidzein, genistein and glycitein) was not associated with preeclampsia risk. The results suggest that increased dietary intake of flavanones (including naringenin), luteolin and quercetin is linked to a decreased preeclampsia risk.

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Section: Resultsmentioning

confidence: 97%

Relationship between Effect of Dietary Flavonoid Intake and Risk of Preeclampsia: A Research Study

Liu,

Kang

et al. 2023

IJPS

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“…This suggest that absence of AM2 function renders increased risk for metabolic disorder under stressful conditions such as establishment of pregnancy. Preeclampsia (PE) and gestational diabetes mellitus (GDM) are common pregnancy complications, occurring only during pregnancy with similar risk factors and patho-physiological changes (Pankiewicz et al, 2022;Yang and Wu, 2022). Evidence from previous studies suggests that the incidence of PE is significantly increased in women with GDM.…”

Section: Discussionmentioning

confidence: 99%

Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice

Yallampalli

Betancourt²,

Mishra³

et al. 2023

Front. Physiol.

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Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation using AM2 knockout mice (AM2−/−).Method: The AM2−/− mice were successfully generated using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Nuclease Cas nine system. Phenotype of pregnant AM2−/− mice was assessed with respect to its fertility, blood pressure regulation, vascular health and metabolic adaptations and compared to the wild type littermates (AM2+/+).Results: Current data shows that AM2−/− females are fertile with no significant difference in number of pups/litter compared to the AM2+/+. However, ablation of AM2 decreases the gestational length and the total number of pups born dead or that die after birth is greater in AM2−/− mice compared to AM2+/+ mice (p < 0.05). Further AM2−/− mice exhibit elevated blood pressure and elevated vascular sensitivity for the contractile responses to angiotensin two and higher serum sFLT-1 trigylcerides levels compared to AM2+/+(p < 0.05). In addition, AM2−/− mice develop glucose intolerance with elevated serum levels of Insulin during pregnancy compared to the AM2+/+mice.Discussion: Current data suggests a physiological role for AM2 in pregnancy induced vascular and metabolic adaptations in mice.

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“…Pregnancy-related PE is known to be associated with GDM, and numerous investigations have established a clear link between these two conditions. 8 The study revealed that women diagnosed with GDM are at a greater risk of getting preeclampsia compared to those who do not have GDM. They proposed that the elevated blood sugar levels and reduced responsiveness to insulin seen in gestational diabetes mellitus (GDM) might potentially contribute to impaired functioning of the endothelium, a characteristic feature of preeclampsia.…”

Section: Introductionmentioning

confidence: 96%

Gestational Diabetes Mellitus And Autonomic Dysfunction: Impact On Preeclampsia Risk

Siddiqui,

Manik,

Srivastava

et al. 2024

jaz

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Gestational diabetes mellitus (GDM) and autonomic dysfunction are two closely connected disorders that have received considerable focus in relation to mother health during pregnancy.This review study seeks to provide a thorough analysis of existing research, investigating the complex connection between GDM (gestational diabetes mellitus), autonomic dysfunction, and their combined influence on the likelihood of developing preeclampsia. Gestational diabetes mellitus (GDM) is a prevalent metabolic condition associated with pregnancy, which is characterised by an impaired ability to process glucose and often occurs for the first-time during pregnancy. Preeclampsia is a complex condition characterised by high blood pressure that occurs only during pregnancy and is often linked to negative consequences for both the mother and the foetus. Autonomic dysfunction, characterised by changes in the sympathetic and parasympathetic nerve systems, is now recognised as a possible factor in the development of both gestational diabetes mellitus (GDM) and preeclampsia. This review will examine the complex relationship between gestational diabetes mellitus (GDM), autonomic dysfunction, and preeclampsia, focusing on the epidemiological, clinical, and molecular aspects. This study aims to investigate the reciprocal association between GDM and autonomic dysfunction, examining the potential for one disease to worsen the other. Moreover, the study will examine the several routes via which autonomic dysfunction may impact the occurrence of preeclampsia in the context of GDM, elucidating the underlying pathophysiological processes. This study seeks to enhance our awareness of the intricate relationship between gestational diabetes mellitus (GDM), autonomic dysfunction, and preeclampsia by

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The Impact of Coexisting Gestational Diabetes Mellitus on the Course of Preeclampsia

Cited by 4 publications

References 60 publications

Relationship between Effect of Dietary Flavonoid Intake and Risk of Preeclampsia: A Research Study

Relationship between Effect of Dietary Flavonoid Intake and Risk of Preeclampsia: A Research Study

Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice

Gestational Diabetes Mellitus And Autonomic Dysfunction: Impact On Preeclampsia Risk

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