The impact of clinicopathological factors on clinical outcomes in patients with salivary gland adenoid cystic carcinoma: a multi-institutional analysis in Japan

Kawakita, Daisuke; Murase, Takayuki; Ueda, Kaori; Kano, Satoshi; Tada, Yuichiro; Tsukahara, Kiyoaki; Okami, Kenji; Onitsuka, Tetsuro; Fujimoto, Yasushi; Matoba, Takuma; Sakurai, Kazuo; Nagao, Toru; Hanai, Nobuhiro; Kawata, Ryo; Hato, Naohito; Nibu, Ken ichi; Urano, Makoto; Taguchi, Ken; Nakaguro, Masato; Kusafuka, Kimihide; Yamamoto, Hidetaka; Nagao, Toshitaka; Inagaki, Hiroshi

doi:10.1007/s10147-020-01731-9

Cited by 19 publications

(24 citation statements)

References 30 publications

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“…Besides that, positive neck nodes and lymphovascular invasion posed further risk factors for distant recurrences, which is in accordance to the work of Ali et al, who additionally identified male sex, high‐grade pathology, and perineural invasion as predictors of distant metastases 18 . Interestingly, overall recurrence rate and rate of distant failures were again comparable to other studies done on low‐grade salivary gland tumors 11,19,20 …”

Section: Discussionsupporting

confidence: 87%

Prognostic factors in mammary analogue secretory carcinomas of the parotid gland: Systematic review and meta‐analysis

et al. 2021

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Mammary analogue secretory carcinomas (MASCs) of the parotid gland are considered as low‐grade malignancies with good clinical outcome but lacking data regarding prognostic factors. We performed meta‐analysis assessing prognostic factors for disease‐free survival (DFS) and overall survival (OS) in 256 patients with MASCs of the parotid gland. A total of 73 studies have met the inclusion criteria and 76.3% of patients were seen with T1 and T2 tumors and negative neck nodes. Lymph node metastasis (57.4%) and distant recurrences (46.2%) were particularly found in T4 tumors (p < 0.001). DFS at 5 and 10 years was 77.9% and 47.2% compared to 88.1% and 77.2% for OS at the same time points. Male sex, T3‐T4 tumors, and recurrent disease represented independent worse prognosticators for survival outcome. Altogether, parotid gland MASCs show good long‐term outcome, but T4 tumors behave significantly more aggressive and require extended treatment strategies along with close follow‐ups.

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Section: Discussionsupporting

confidence: 87%

Prognostic factors in mammary analogue secretory carcinomas of the parotid gland: Systematic review and meta‐analysis

et al. 2021

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“…[ 38 ] In contrast, a recent multi-institutional retrospective analysis in Japan showed that prophylactic neck dissection for the salivary glands ACC was not associated with better clinical outcomes in the 5 year observation periods. [ 39 ] Garg et al reviewed the literature and reported that prophylactic neck dissection for N0 cases in ACC can provide accurate cancer staging, prognostic prediction, and locoregional control, even if it does not contribute to overall survival. [ 36 ] With regard to the significance of postoperative radiotherapy, no consensus has been reached yet.…”

Section: Discussionmentioning

confidence: 99%

“…The reported clinicopathological prognostic factors of salivary gland ACC are higher T and N classification, higher solid pattern components, and pathologically positive surgical margins. [ 4 , 39 , 45 ]…”

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the sublingual gland developing lung metastasis 20 years after primary treatment

et al. 2021

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Rationale: Adenoid cystic carcinoma (ACC) is a rare malignant tumor that primarily occurs in the salivary glands. Distant metastases can develop despite favorable local control. Moreover, distant metastasis of ACC can occur after a long time interval without local recurrence. We report the first case of ACC of the sublingual gland that developed lung metastasis 20 years after primary treatment. Patient concerns: A 52-year-old man was referred to our department with a 1-year history of painful swelling on the right oral floor. Diagnosis: An incisional biopsy was performed, and histopathological examination revealed malignancy. Interventions: Surgical excision of the right oral floor and right supra-omohyoid neck dissection with postoperative chemoradiation therapy were performed, and ACC of the sublingual gland was diagnosed. Left pulmonary metastasis was detected 20 years after the primary treatment. Metastasectomy was performed; however, subsequently, skin and bone metastases developed. Outcomes: After receiving palliative care, the patient died of multiple organ failure. Lessons: As late distant metastasis of salivary ACC can develop, patients who undergo primary treatment need a long-term, strict follow-up plan even if locoregional control is favorable.

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“…Park et al investigated the survival outcome of 108 intermediate-grade SGC patients in their study, from which the most common histologic type was MEC and ACC; the result suggested that a non-parotid primary site is an independent prognostic factor for poor RFS [ 64 ]. For ACC and SDC, patients with parotid gland tumors demonstrated more favorable survival outcomes [ 65 , 66 ], And a primary site in the submandibular gland was an independent prognostic factor for worse survival outcomes [ 63 , 67 ]. The tumor site (major and minor salivary gland) did not affect survival in Ca-ex-PA patients [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis

Jiang

Zhu

et al. 2022

PLoS ONE

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Background Although programmed cell death-ligand 1 (PD-L1) has been recognized as a potential marker in several cancers, the relationship between PD-L1 expression and survival in patients with salivary gland carcinoma (SGC) has remained unclear. We aimed to evaluate the association of PD-L1 expression with clinicopathological features and prognosis in SGC patients. Methods The databases Ovid Medline, PubMed, Scopus, and EMBASE were searched for relevant studies that detected PD-L1 expression in SGC. The meta-analysis was performed according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA), and the reporting recommendations for tumor marker prognostic studies (REMARK) was used to assess the quality of research eligible for this meta-analysis. Included studies were assessed using the Quality in Prognosis Studies (QUIPS) tool. Odds ratios (ORs) with 95% confidence interval (CI) were calculated to estimate the correlation between PD-L1 expression and clinicopathological features. Hazard ratios (HRs) with 95% CI were applied to assess the association between PD-L1 expression and survival outcomes of patients. Results A total of ten studies (including 952 patients with SGC) were evaluated. The meta-analysis showed that positive PD-L1 expression in SGC was significantly associated with male patients, older age, Tumor stage, lymph node metastasis, high pathological grade, and non-adenoid cystic carcinoma subtype. The pooled data demonstrated that high PD-L1 expression was associated with poor overall survival and disease-free survival. There was no significant correlation between PD-L1 expression and progression-free survival or disease-specific survival of SGC patients. Conclusion According to the meta-analysis, positive PD-L1 expression may play an important role as an effective marker of poor prognosis in patients with SGC. However, large-scale, prospective investigations are still needed to confirm the findings. The assessment of PD-L1 expression may aid in the personalized management of SGC.

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The impact of clinicopathological factors on clinical outcomes in patients with salivary gland adenoid cystic carcinoma: a multi-institutional analysis in Japan

Cited by 19 publications

References 30 publications

Prognostic factors in mammary analogue secretory carcinomas of the parotid gland: Systematic review and meta‐analysis

Prognostic factors in mammary analogue secretory carcinomas of the parotid gland: Systematic review and meta‐analysis

Adenoid cystic carcinoma of the sublingual gland developing lung metastasis 20 years after primary treatment

Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis

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