The impact of clinical practice on the outcome of central venous access devices in children with haemophilia

Abstract

Use of sterile gloves and gowns did not reduce the risk of port infection. Using less stringent sterile techniques for accessing ports is easier for caregivers and in addition may have health economic benefits.

Complication rates of central venous access devices in patients with inherited bleeding disorders in Australia

“…The total infection rate seen in our study, of 0·54/1000 CVAD days, is comparable to recent multi‐centre studies (Rodriguez et al , ; Khair et al , ), however is higher than the recent single centre studies and small multi‐centre trials (Harroche et al , ; Langley et al , ; McCarthy et al , ). The reason for a higher rate is probably multifactorial.…”

“…This study reports on the second largest group of patients since the report by Khair et al (), who retrospectively studied 240 patients with haemophilia. However, the present study is limited by its retrospective nature.…”

“…Since a meta-analysis by Valentino et al (2004) which reported a pooled rate of 0Á66 infections/ 1000 catheter days, the rate of infectious complications reported has continued to decrease, varying from 0Á0578 infections/1000 catheter days (Harroche et al, 2015), to 0Á57 infections/1000 catheter days (Mancuso et al, 2008). Singlecentre studies report lower rates of infection compared with multi-centre studies, which probably reflects the heterogeneity in practice surrounding CVADs and, perhaps, reporting bias (Khair et al, 2017). Non-infectious complications of CVAD suffer even greater issues with heterogeneity in the literature.…”

“…Malfunction rates are rarely reported in the literature, however, in this study, they were shown to be significantly more common than thrombotic complications and reporting this would, therefore, be of benefit. This study reports on the second largest group of patients since the report by Khair et al (2017), who retrospectively studied 240 patients with haemophilia. However, the present study is limited by its retrospective nature.…”

Burden on parents of children with haemophilia: The impact of sociodemographic and child's medical condition

“…Parents play a key role in functional home treatment as they administer the intravenous injections to the child. In Sweden, the injections are usually given peripherally, whereas in other countries, Central Venous Access Devicesare more common (Khair, Ranta, Thomas, & Lindvall, 2017;Lee, 2014).…”