The impact of climate change on the risk factors for tuberculosis: A systematic review

Kharwadkar, Sahil; Attanayake, Vinal; Duncan, John S.; Navaratne, Novindu; Benson, Jill

doi:10.1016/j.envres.2022.113436

Cited by 23 publications

(21 citation statements)

References 87 publications

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“…The researchers noted: ‘Climate change affects tuberculosis through diverse pathways: changes in climatic factors like temperature, humidity, and precipitation influence host response through alterations in vitamin D distribution, ultraviolet radiation, malnutrition, and other risk factors’ 43 . Systematic reviews on climate change and tuberculosis 2021–22 found evidence supporting a positive association between climate change and each of the discussed risk factors for tuberculosis 43 ; 44 . Researchers believe that ‘ further studies and novel methodologies are required to address such a complex relationship and better understand the occurrence of tuberculosis attributable to climate change’ 43 .…”

Section: Resultsmentioning

confidence: 99%

Climate in the Treatment of Pulmonary Tuberculosis in the First Half 19th Century: The Case of Frederic Chopin

Berezutskyi,

Berezutska

2024

Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin

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Background The famous Polish composer Frederic Chopin (1810–1849) suffered almost all his short life from pulmonary tuberculosis. Physical treatment and climate therapy are the only aspect of Chopin’s disease history that has not yet been thoroughly studied. The etiology of tuberculosis in Chopin’s time was not yet known, so physical means and changes in climate in the first half of the 19th century were the most important part of the physicians’ therapeutic arsenal in the treatment of pulmonary tuberculosis. Objectives are to study the use of physical methods and climate therapy in the treatment of Frederic Chopin. Methods Scopus, WoS, MedLine, and PubMed data-bases, electronic archives were searched without time restriction for information on the use of physical methods and climate therapy in the treatment of pulmonary tuberculosis in the first half of the 19th century in Europe. The analysis was also made of Chopin’s letters and the work of his most respected biographers in order to identify information about physical therapy in his treatment. Results Chopin’s disease had been actively progressing since 1835. According to the proper 19th-century tuberculosis treatment plan which was set out in the treatises of prominent European physicians, Chopin was treated with physical means: blister plasters, cupping, creosote inhalations, sulfur baths, opium and belladonna plasters. Changing the climate in winter (southern France or Italy) was also a standard recommendation. In October 1838, Chopin, who was still recovering from another seasonal exacerbation of pulmonary tuberculosis, took a trip to Mallorca, where he spent the winter. Conclusions Chopin had the advanced stage of consumption, which was already regarded at that time as a contraindication to climate change. The destination was also unsuitable for patients with pulmonary tuberculosis: winter climate of Majorca, characterized by high humidity and strong winds, negatively affected Chopin’s health. The disease was manifested by fever, hemoptysis, shortness of breath and exhaustion, which indicated tuberculosis intoxication and destruction of lung tissue. Chopin’s trip to Majorca 1838/1839 will forever go down in the history of climate therapy as an example of the negative consequences of ignoring contraindications to climate change.

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Section: Resultsmentioning

confidence: 99%

Climate in the Treatment of Pulmonary Tuberculosis in the First Half 19th Century: The Case of Frederic Chopin

Berezutskyi,

Berezutska

2024

Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin

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“…The impacts of climate change are directly linked with disproportionately detrimental health outcomes for populations in LMICs. For instance, there are noted associations in LMICs between climate change and tuberculosis risk factors (eg, overcrowding, poverty, diabetes, undernutrition) [9] and climate-related disasters and mental health challenges (eg, storm-related post-traumatic stress disorder, flood-related depression) [10]. Evolving climate disasters will also increase migration health crises, leading to greater health risks and barriers to health and social wellbeing while living in or being forcibly displaced to LMICs [11].…”

Section: Palliative Care Inequities and Palliative Justicementioning

confidence: 99%

Palliative Justice Post-COP27

Rosa

Grant

2023

Yale J Biol Med

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The climate crisis is a planetary existential threat, disproportionately affecting the poorest populations worldwide. People in low-and middle-income countries (LMICs) experience the most detrimental consequences of climate injustice, endangering their livelihoods, safety, overall wellbeing, and survival. Although the 2022 United Nations Climate Change Conference (COP27) put forth several internationally salient recommendations, the outcomes fall short to efficiently tackle the suffering that exists at the intersection of social and climate injustice. Individuals with serious illness living in LMICs have the highest burden of health-related suffering globally. In fact, more than 61 million people experience serious healthrelated suffering (SHS) each year that is amenable to palliative care. Despite this well-documented burden of SHS, an estimated 88-90% of palliative care need is unmet, the majority in LMICs. To equitably address suffering at individual, population, and planetary levels in LMICs, a palliative justice approach is crucial. The interplay of human and planetary suffering requires that current planetary health recommendations be expanded to incorporate a whole-person and whole-people perspective that recognizes the need for environmentally conscious and community-based research and policy initiatives. Conversely, palliative care efforts should incorporate planetary health considerations to ensure sustainability in capacity building and service provision. In sum, the optimal health of the planet will remain elusive until we can holistically recognize the value of relieving all suffering due to life-limiting conditions, as well as the value in preserving the natural resources of countries in which all people are born, live, age, suffer, die, and grieve.

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“…Tuberculosis (TB) remains a major global public health threat, infecting and killing mainly in developing countries [1,2]. The reason why TB is so difficult to treat is because of the TB bacterium's three "weapons": persistence [3], drug resistance [4] and virulence [5].…”

Section: Introductionmentioning

confidence: 99%

LC-MS/MS method assay for simultaneous determination of the pretomanid and pyrazinamide in rat plasma by LC-MS/MS: Assessment of pharmacokinetic drug-drug interaction study

Huang

Wang

et al. 2024

AChrom

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In the present study, an LC-MS/MS method allowing to quantify pretomanid and pyrazinamide simultaneously in rat plasma was developed. Chromatographic separation was achieved on an Agilent Eclipse plus C18 column (100 mm × 2.1 mm, 3.5 μm; Agilent, USA) and maintained at 30 °C. Multiple reaction monitoring (MRM) using positive-ion ESI mode to monitor ion transitions of m/z 360.1 → m/z 175.1 for pretomanid, m/z 124.1 → m/z 81.0 for pyrazinamide, m/z 172.1 → m/z 128.1 for metronidazole (IS). The calibration curves showed good linear relationships over the concentration range of 50–7,500 ng mL−1 for pretomanid and 500–75,000 ng mL−1 for pyrazinamide. The precision and accuracy were below 15% and within ±15% of the nominal concentrations, respectively. The selectivity, recovery and matrix effect of this method were all within acceptable limits of bioanalytics. The method was applied to the analysis of plasma samples from pharmacokinetic studies in rats. The results show that the main pharmacokinetic parameters of pyrazinamide, namely, Tmax, t1/2, and AUC(0–t), decreased in the combined group than in the alone group.

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The impact of climate change on the risk factors for tuberculosis: A systematic review

Cited by 23 publications

References 87 publications

Climate in the Treatment of Pulmonary Tuberculosis in the First Half 19th Century: The Case of Frederic Chopin

Climate in the Treatment of Pulmonary Tuberculosis in the First Half 19th Century: The Case of Frederic Chopin

Palliative Justice Post-COP27

LC-MS/MS method assay for simultaneous determination of the pretomanid and pyrazinamide in rat plasma by LC-MS/MS: Assessment of pharmacokinetic drug-drug interaction study

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