The impact of chronic primary insomnia on the heart rate – EEG variability link

Jurysta, Fabrice; Lanquart, Jean Pol; Sputaels, V.; Dumont, Martine; Migeotte, Pierre-François; Leistedt, Samuel; Linkowski, Paul; Borne, P van de

doi:10.1016/j.clinph.2009.03.019

Cited by 86 publications

(76 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Effect sizes for polysomnographically determined sleep were taken from the same meta-analysis [25•]. With respect to physiological variables, standardized mean effect sizes were calculated for NREM EEG beta activity [22,[26][27][28][29][30][31][32][33] and resting heart rate [34][35][36][37][38][39][40] as the two most frequently investigated putative physiological indicators of hyperarousal in insomnia. Effect sizes for daytime cognitive performance were taken from the meta-analysis of Fortier-Brochu et al [5].…”

Section: The Promise Of Neuroimagingmentioning

confidence: 99%

Neuroimaging Insights into Insomnia

Spiegelhalder

Regen

Baglioni

et al. 2015

Curr Neurol Neurosci Rep

View full text Add to dashboard Cite

Insomnia is one of the most prevalent health complaints afflicting approximately 10% of the population in Western industrialized countries at a clinical level. Despite the proposition that both biological and psychological factors play a role in the experience of insomnia, the field continues to puzzle over so-called "discrepancies" between objective and subjective measurements of sleep and daytime functioning. The promise of neuroimaging is to uncover physiological processes that may readily explain patient reports. However, while there has been an explosion in the number of studies investigating the neural correlates of insomnia with neuroimaging technologies, there appears to be little consistency in findings across studies. We suggest a number of methodological reasons which may, at least partially, explain variability in findings across neuroimaging studies in insomnia.

show abstract

Section: The Promise Of Neuroimagingmentioning

confidence: 99%

Neuroimaging Insights into Insomnia

Spiegelhalder

Regen

Baglioni

et al. 2015

Curr Neurol Neurosci Rep

View full text Add to dashboard Cite

show abstract

“…For example, aging is associated with a reduction in delta activity and an increase in the LF/HF ratio during NREM sleep [8,30]. Similarly, a number of disorders have been identified that are characterized by low levels of delta activity and high sympathovagal balance, including insomnia [28], fibromyalgia [41], sleep apnea [29], and alcohol dependence [26]. Further, acute stress imposed before sleep has been shown to reduce the amount of delta activity and increase sympathovagal balance during sleep [21].…”

Section: The Effect Of Cardiovascular Activity On Sleepmentioning

confidence: 99%

“…Some studies have reported elevated sympathovagal balance and reduced delta activity in a population, such as older individuals, but not reduced coherence between the two measures [30], while other studies have not found differences in autonomic tone or delta activity, but have found differences in various measures derived from coherence analysis [27]. Further, in studies in which coherence analysis has revealed differences, the particular coherence measure has differed, some studies reporting differences in gain [27,29] and others differences in coherence [28]. Nevertheless, while these inconsistencies are troubling, the speculation that vagal activity during NREM sleep is necessary for the full development of EEG synchronization and that a shift to sympathetic dominance due to stress, or a sleep or medical disorder, will disrupt the development of EEG delta activity, is an intriguing hypothesis.…”

Section: The Effect Of Cardiovascular Activity On Sleepmentioning

confidence: 99%

Sleep and cardiovascular regulation

Trinder

Waloszek

Woods

et al. 2011

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

Normal sleep has a profound effect on the cardiovascular system, reducing cardiovascular activity throughout non-rapid eye movement sleep; changes that are modified and augmented by circadian system influence. There is also evidence that sleep-initiated changes in autonomic balance may in turn modify the development of sleep within a night, particularly the development of slow wave sleep. It is assumed that the cardiovascular changes that accompany sleep reflect a functional aspect of sleep, although the precise functional role has not been agreed upon. Nevertheless, there is good evidence that the cardiovascular changes that occur during normal sleep are beneficial for the cardiovascular system. Arousals from sleep, which are common even in normal sleep, are associated with a surge in activity in cardiorespiratory systems, with marked effects on the sleep-related pattern of cardiovascular activity when they occur frequently. Despite the importance of this aspect of sleep, controversy remains as to both the nature of the activation response and the circumstances under which it is elicited. The concept that sleep-related changes in cardiovascular activity are beneficial leads to the corollary that sleep disturbance would result in adverse cardiovascular consequences. While there is strong empirical evidence for such a relationship, it remains unclear whether this is a direct effect or, as has been suggested recently, the effect of disturbed sleep is mediated via stress-related modification of neuroendocrine systems.

show abstract

“…Studies have shown that individuals with chronic insomnia produce fewer responses in a word category test [1], made more errors in a line-tracing test [2] and performed worse in a balance test [3]. Sateia & Nowell [4] suggested that chronic insomnia may heighten an individual's chances of developing other chronic medical disorders such as diabetes, arthritis and heart disease, whereas Jurysta et al [5] hypothesized that the altered interaction between heart rate variability (HRV) and delta sleep in insomnia patients could reflect the first step to a cardiac disorder. Other researchers have gone further and suggest that chronic insomnia is a risk factor for the onset of major depression, conferring a twofold increased risk [6,7].…”

Section: Introductionmentioning

confidence: 99%

Complexity analysis of sleep and alterations with insomnia based on non-invasive techniques

Holloway

Angelova

Lombardo

et al. 2014

J. R. Soc. Interface.

View full text Add to dashboard Cite

For the first time, fractal analysis techniques are implemented to study the correlations present in sleep actigraphy for individuals suffering from acute insomnia with comparisons made against healthy subjects. Analysis was carried out for 21 healthy individuals with no diagnosed sleep disorders and 26 subjects diagnosed with acute insomnia during night-time hours. Detrended fluctuation analysis was applied in order to look for 1/f-fluctuations indicative of high complexity. The aim is to investigate whether complexity analysis can differentiate between people who sleep normally and people who suffer from acute insomnia. We hypothesize that the complexity will be higher in subjects who suffer from acute insomnia owing to increased night-time arousals. This hypothesis, although contrary to much of the literature surrounding complexity in physiology, was found to be correct-for our study. The complexity results for nearly all of the subjects fell within a 1/f-range, indicating the presence of underlying control mechanisms. The subjects with acute insomnia displayed significantly higher correlations, confirmed by significance testingpossibly a result of too much activity in the underlying regulatory systems. Moreover, we found a linear relationship between complexity and variability, both of which increased with the onset of insomnia. Complexity analysis is very promising and could prove to be a useful non-invasive identifier for people who suffer from sleep disorders such as insomnia.

show abstract

The impact of chronic primary insomnia on the heart rate – EEG variability link

Cited by 86 publications

References 47 publications

Neuroimaging Insights into Insomnia

Neuroimaging Insights into Insomnia

Sleep and cardiovascular regulation

Complexity analysis of sleep and alterations with insomnia based on non-invasive techniques

Contact Info

Product

Resources

About