The impact of chronic exposure to air pollution over oxidative stress parameters and brain histology

Bernardi, Rosane; Zanchi, Ana Claudia; Damaceno-Rodrigues, Nilsa Regina; Veras, Mariana Matera; Saldiva, Paulo Hilário Nascimento; Barros, Helena Maria Tannhauser; Rhoden, Cláudia Ramos

doi:10.1007/s11356-021-14023-0

Cited by 8 publications

(3 citation statements)

References 78 publications

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“…Experiments in mice suggest that the cortex may have a lower threshold for lasting air pollution-related disruptions than subcortical regions (Bernardi et al, 2021), evidenced by greater increases in microglia and a larger window of antioxidant system susceptibility in cortex, compared to the striatum. These findings highlight the importance of the present work, as the neurotoxicity of air pollution is relatively less investigated in the potentially more susceptible cortex.…”

Section: Exposures Within Federal Air Quality Standards Linked To Dif...mentioning

confidence: 99%

Air pollution from biomass burning disrupts early adolescent cortical microarchitecture development

Bottenhorn,

Sukumaran,

Cardenas-Iniguez

et al. 2023

Preprint

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Exposure to outdoor particulate matter (PM2.5) represents a ubiquitous threat to human health and, in particular, the neurotoxic effects of PM2.5 from multiple sources may disrupt neurodevelopment. Studies addressing neurodevelopmental implications of PM exposure have been limited by small, geographically-limited samples and largely focus either on macroscale cortical morphology or postmortem histological staining and total PM mass. Here, we leverage residentially-assigned exposure to six, data-driven sources of PM2.5 and neuroimaging data from the longitudinal Adolescent Brain Cognitive Development Study (ABCD Study), collected from 21 different recruitment sites across the United States. To contribute an interpretable and actionable assessment of the role of air pollution in the developing brain, we identified alterations in cortical microstructure development associated with exposure to specific sources of PM2.5 using multivariate, partial least squares analyses. Specifically, average annual exposure (i.e., at ages 8-10 years) to PM2.5 from biomass burning was related to impaired neurite development across the cortex between 9 and 13 years of age.

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Section: Exposures Within Federal Air Quality Standards Linked To Dif...mentioning

confidence: 99%

Air pollution from biomass burning disrupts early adolescent cortical microarchitecture development

Bottenhorn,

Sukumaran,

Cardenas-Iniguez

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Exposure to DEP deregulated the expression of several transporters and receptors that are critically involved in BBB functionality namely ABCB1, multidrug-resistance associated proteins (MRP)1, MRP2, MRP4, breast cancer resistance protein (BCRP), glucose transporter (GLUT)1, and the metabolizing enzyme glutathione S-transferase (GST)π (Hartz et al, 2008). Several reports have demonstrated an increased BBB permeability following exposure to a mixed vehicular emission, translated essentially by deregulation of the TJs (Rojas et al, 2011;Oppenheim et al, 2013;Bernardi et al, 2021). For instance, human brain microvascular endothelial cells in culture exposed to nanoparticles of aluminum oxide exhibit reduced cell viability, altered mitochondrial function, increased oxidative stress, and diminished expression of the TJs proteins claudin-5 and occludin (Chen et al, 2008;Block and Calderón-Garcidueñas, 2009).…”

Section: Impact On Endothelial Functionsmentioning

confidence: 99%

“…PM has been demonstrated to impact neuron-glial crosstalk. Acute exposure of adult mice to PM 2.5 increased the levels of lipoperoxidation and proinflammatory cytokines in the brain and activated microglia, accompanied by reduced neurogenesis in the subgranular zone (SGZ) and subventricular zone (SVZ; Bernardi et al, 2021). Neuronal cell cultures exhibited reduced viability upon exposure to PM 2.5 associated with increased release of glutamate (Liu F. et al, 2015).…”

Section: Impact On Microglial Reactivity and Consequences On Neuronsmentioning

confidence: 99%

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors

Lecordier

Manrique-Castano

Moghrabi

et al. 2021

Front. Aging Neurosci.

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Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the world after Alzheimer’s disease (AD). VaD regroups heterogeneous neurological conditions in which the decline of cognitive functions, including executive functions, is associated with structural and functional alterations in the cerebral vasculature. Among these cerebrovascular disorders, major stroke, and cerebral small vessel disease (cSVD) constitute the major risk factors for VaD. These conditions alter neurovascular functions leading to blood-brain barrier (BBB) deregulation, neurovascular coupling dysfunction, and inflammation. Accumulation of neurovascular impairments over time underlies the cognitive function decline associated with VaD. Furthermore, several vascular risk factors, such as hypertension, obesity, and diabetes have been shown to exacerbate neurovascular impairments and thus increase VaD prevalence. Importantly, air pollution constitutes an underestimated risk factor that triggers vascular dysfunction via inflammation and oxidative stress. The review summarizes the current knowledge related to the pathological mechanisms linking neurovascular impairments associated with stroke, cSVD, and vascular risk factors with a particular emphasis on air pollution, to VaD etiology and progression. Furthermore, the review discusses the major challenges to fully elucidate the pathobiology of VaD, as well as research directions to outline new therapeutic interventions.

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Histopathological Evaluation of the Cerebrum in Neonatal Rats Following PM2.5 Particle Inhalation

Momayez Sefat,

Mortazavi,

Motesaddi Zarandi

et al. 2023

Water Air Soil Pollut

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The impact of chronic exposure to air pollution over oxidative stress parameters and brain histology

Cited by 8 publications

References 78 publications

Air pollution from biomass burning disrupts early adolescent cortical microarchitecture development

Air pollution from biomass burning disrupts early adolescent cortical microarchitecture development

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors

Histopathological Evaluation of the Cerebrum in Neonatal Rats Following PM2.5 Particle Inhalation

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