The impact of chronic bupropion on plasma cotinine and on the subjective effects of ad lib smoking: A randomized controlled trial in unmotivated smokers

Hussain, Sarwar; Zawertailo, Laurie; Busto, Usoa E.; Zack, Martin; Farvolden, Peter; Selby, Peter

doi:10.1016/j.addbeh.2009.09.004

Cited by 16 publications

(16 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Varenicline did however attenuate cue-provoked craving on days 12–15. Chronic NRT dosing (i.e., transdermal patch) (Havermans et al, 2003; Morissette et al, 2005; Rohsenow et al, 2007; Tiffany et al, 2000; Waters et al, 2004), bupropion (Hussain et al, 2010), and acute smoking satiety (Drobes and Tiffany, 1997; Maude-Griffin and Tiffany, 1996) have all been shown to attenuate tonic, but not cue-provoked craving (Ferguson and Shiffman, 2009). …”

Section: Discussionmentioning

confidence: 99%

Dissociable effect of acute varenicline on tonic versus cue-provoked craving in non-treatment-motivated heavy smokers

Hitsman

Hogarth

Tseng

et al. 2013

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Rationale The effectiveness of varenicline for smoking cessation has been established, but little is known about the psychological processes that mediate this clinical outcome. Objectives This study evaluated the effect of a single dose of varenicline on tonic and cue-provoked changes in craving, withdrawal, and affect using a randomized, double-blind, placebo-controlled, cross-over design. Methods Following overnight abstinence, 38 non-treatment-motivated smokers received either varenicline 2 mg or matched placebo, then tonic measures of craving, withdrawal, and positive and negative affect were obtained at 30-minute intervals. At 4-hours post-administration, a cue exposure session obtained the same subjective measures at three time-points following the physical handling of a lit cigarette versus the sharpening and handling of a pencil. Results At 4-hours post-administration, varenicline reduced tonic craving as well as craving across the smoking and neutral cue conditions, relative to placebo. By contrast, the capacity of the smoking cue to enhance craving relative to the neutral cue was unaffected by varenicline. Measures of withdrawal and positive and negative affect produced mixed results. Conclusions Acute varenicline selectively attenuates tonic but not cue-provoked craving. This dissociation provides insight into the specific psychological processes that might mediate the effectiveness of varenicline, and highlights cue-provoked craving as a discrete target for advancing smoking cessation pharmacotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Dissociable effect of acute varenicline on tonic versus cue-provoked craving in non-treatment-motivated heavy smokers

Hitsman

Hogarth

Tseng

et al. 2013

Drug and Alcohol Dependence

View full text Add to dashboard Cite

show abstract

“…Apart from mecamylamine (Marx et al, 2000;McKee et al, 2009;Rose et al, 2001Rose et al, , 2003, these considered the effects of bupropion, a dopamine re-uptake inhibitor (Cousins et al, 2001;Hatsukami et al, 2004;Hussain et al, 2010) and amphetamine, a dopamine re-uptake inhibitor (Cousins et al, 2001). Acute administration of mecamylamine led to an increase in smoking intensity, both in terms of CPD and puff volume (Marx et al, 2000;McKee et al, 2009;Rose et al, 2001Rose et al, , 2003, whereas chronic mecamylamine administration leads to decreased number of cigarettes smoked daily and expired air carbon monoxide, presumably through an extinction mechanism (Rose et al, 1998).…”

Section: Smoking and Simultaneous Application Of Nicotine Agonists Ormentioning

confidence: 97%

Smoking behaviour and compensation: A review of the literature with meta-analysis

Scherer

2014

Regulatory Toxicology and Pharmacology

View full text Add to dashboard Cite

“…The dual-controller account elaborated above provides a framework for explaining why tonic cigarette craving but not cue-elicited craving is modulated by abstinence/satiety (Drobes & Tiffany, 1997;Hogarth, et al, 2010;Maude-Griffin & Tiffany, 1996) nicotine replacement therapy (Havermans, et al, 2003;Morissette, et al, 2005;Niaura, et al, 2005;Rohsenow, et al, 2007;Shiffman, et al, 2003;Tiffany, et al, 2000;Waters, et al, 2004), bupropion (Hussain, et al, 2010) and varenicline (Brandon, et al, 2011;Franklin, et al, 2011;Hitsman, et al, under review;Hitsman, et al, 2006). The current analysis suggests that these treatments induce or mimic internal states which have undergone incentive learning and so modulate expectations regarding the current incentive value of tobacco, which determines overall propensity to engage in goal-directed tobacco-seeking (tonic craving).…”

Section: Discussionmentioning

confidence: 99%

“…As with manipulations of smoking deprivation and satiety described above, smoking cessation medications have been shown to attenuate tonic cigarette craving but not cue-elicited craving (for a review see Ferguson & Shiffman, 2009). This dissociation has been found with nicotine replacement therapy (Havermans, Debaere, Smulders, Wiers, & Jansen, 2003;Morissette, Palfai, Gulliver, Spiegel, & Barlow, 2005;Niaura et al, 2005;Rohsenow et al, 2007;Shiffman et al, 2003;Tiffany, Cox, & Elash, 2000;Waters et al, 2004), bupropion (Hussain et al, 2010) and varenicline (Brandon et al, 2011;Franklin et al, 2011;Hitsman et al, under review;Hitsman, Niaura, Shadel, Britt, & Price, 2006; for related animal data see O'Connor, Parker, Rollema, & Mead, 2010). Dual-controller theory explains these dissociations by suggesting that although pharmacotherapies modulate the expected value smoking and thus impact on goal-directed tobacco-seeking, they do not modify expected drug probability and so leave cue-elicited tobacco-seeking intact.…”

Section: Introductionmentioning

confidence: 99%

Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: Evidence for independent additive controllers.

Hogarth

2012

Journal of Experimental Psychology: Animal Behavior Processes

138

View full text Add to dashboard Cite

According to contemporary learning theory, drug-seeking behaviour reflects the summation of two dissociable controllers. Whereas goal-directed drug-seeking is determined by the expected current incentive value of the drug, stimulus-elicited drug-seeking is determined by the expected probability of the drug independently of its current incentive value, and these two controllers contribute additively to observed drug-seeking. One applied prediction of this model is that smoking cessation pharmacotherapies selectively attenuate tonic but not cueelicited craving because they downgrade the expected incentive value of the drug but leave expected probability intact. To test this, the current study examined whether nicotine replacement therapy (NRT) nasal spray would modify goal-directed tobacco choice in a human outcome devaluation procedure, but leave cue-elicited tobacco choice in a Pavlovian to instrumental transfer (PIT) procedure intact. Smokers (n=96) first underwent concurrent choice training in which two responses earned tobacco or chocolate points respectively.Participants then ingested either NRT nasal spray (1mg) or chocolate (147g) to devalue one outcome. Concurrent choice was then tested again in extinction to measure goal-directed control of choice, and in a PIT test to measure the extent to which tobacco and chocolate stimuli enhanced choice of the same outcome. It was found that NRT modified tobacco choice in the extinction test but not the extent to which the tobacco stimulus enhanced choice of the tobacco outcome in the PIT test. This dissociation suggests that the propensity to engage in drug-seeking is determined independently by the expected value and probability of the drug, and that the partial efficacy of pharmacotherapy is due to its selective effect on expected drug value.

show abstract

The impact of chronic bupropion on plasma cotinine and on the subjective effects of ad lib smoking: A randomized controlled trial in unmotivated smokers

Cited by 16 publications

References 20 publications

Dissociable effect of acute varenicline on tonic versus cue-provoked craving in non-treatment-motivated heavy smokers

Dissociable effect of acute varenicline on tonic versus cue-provoked craving in non-treatment-motivated heavy smokers

Smoking behaviour and compensation: A review of the literature with meta-analysis

Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: Evidence for independent additive controllers.

Contact Info

Product

Resources

About