The Impact of Chromium Supplementation on Blood Pressure: A Systematic Review and Dose–Response Meta‑Analysis of Randomized‑Controlled Trials

Lari, Arezou; Fatahi, Somaye; Sohouli, Mohammad Hassan; Shidfar, Farzad

doi:10.1007/s40292-021-00456-8

Cited by 6 publications

(5 citation statements)

References 47 publications

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“…In a systematic review of 9 RCTs, chromium supplementation was not effective in the treatment of obesity [111]. By contrast the meta-analysis of 11 trials testing chromium supplements shows that chromium significantly reduces both systolic and diastolic pressures [112].…”

Section: Deficiencymentioning

confidence: 94%

ESPEN micronutrient guideline

et al. 2022

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Section: Deficiencymentioning

confidence: 94%

ESPEN micronutrient guideline

et al. 2022

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“…A recent meta‐analysis of 11 eligible randomized controlled trials with 637 participants indicated that supplementation with chromium significantly decrease blood pressures. 32 In another human study of 62 patients, chromium levels were found significantly higher in patients with systolic ischemic heart disease. 33 The exact mechanisms of how chromium contribute to PAH disease progression is unknown.…”

Section: Discussionmentioning

confidence: 94%

“…Higher chromium levels showed correlations with worse mixed venous oxygenation, worse 6 min walk, and higher heart failure markers. A recent meta‐analysis of 11 eligible randomized controlled trials with 637 participants indicated that supplementation with chromium significantly decrease blood pressures 32 . In another human study of 62 patients, chromium levels were found significantly higher in patients with systolic ischemic heart disease 33 .…”

Section: Discussionmentioning

confidence: 99%

Metallomics in pulmonary arterial hypertension patients

El‐Kersh

Hopkins²,

Wu³

et al. 2023

Pulm. circ.

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Pulmonary arterial hypertension (PAH) prevalence is increasing worldwide, and the prognosis is poor with 5‐year survival < 50% in high risk patients. The relationship between metal exposure/essential metal dyshomeostasis and PAH/right ventricular dysfunction is less investigated. The aim of this study is to investigate vegetable consumptions and metal levels between PAH patients and controls. This was a prospective, single center pilot study. Questionnaires were completed by all study subjects (20 PAH patients and 10 healthy controls) on smoking, metal exposure risks, metal supplements, and vegetable consumptions. Blood and urine samples were collected to measure 25 metal levels in blood, plasma, and urine using an X Series II quadrupole inductively coupled plasma mass spectrometry. Statistical analysis was conducted using SAS 9.5 and results with p value < 0.05 were considered significant. Vegetables consumptions (broccoli risk ratio [RR] = 0.4, CI = (0.2, 0.9)], cabbage [RR = 0.2, CI = (0.1, 0.8)], and brussel sprouts [RR = 0.2, CI = (0.1, 0.5)]) are associated with less risks of PAH. In the plasma samples, silver ( p < 0.001), and copper ( p = 0.002) levels were significantly higher in PAH patients. There was significant positive correlation between cardiac output and cardiac index with plasma levels of silver ( r = 0.665, p = 0.001 and r = 0.678 p = 0.001), respectively. There was significant correlation between mixed venous saturation, 6‐min walk distance, and last BNP with plasma levels of chromium ( r = −0.520, p = 0.022; r = −0.55, p = 0.014; r = 0.463, p = 0.039), respectively. In conclusion, there are significant differences between PAH and control groups in terms of vegetable consumptions and metal concentrations. Silver and chromium levels are correlated with clinical indicators of PAH severities.

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“…One study found that chromium supplementation significantly reduced both systolic and diastolic blood pressure, and the reduction in systolic blood pressure was greater in participants given chromium yeast [9]. An investigation into the effects of micronutrients on hypertensive patients in rural China suggested independent associations between serum concentrations of copper, selenium, and chromium with hypertension.…”

Section: Fig 3 Subgropup Analysis For the Association Between Urinary...mentioning

confidence: 99%

“…Lower plasma chromium levels have been linked to hyperglycemia, hyperinsulinemia, hypertension, and insulin resistance [8]. Intriguingly, a meta-analysis contradicts these findings by revealing that chromium supplementation significantly diminishes both systolic and diastolic blood pressure [9]. Conversely, another meta-analysis indicates that chromium supplementation doesn't notably alter systolic blood pressure, with no discernible correlation between blood pressure levels and the dose or duration of chromium supplementation [10].…”

Section: Introductionmentioning

confidence: 99%

The association between the urinary chromium and blood pressure: a population-based study

Liang,

Liu,

Yang

2024

BMC Cardiovasc Disord

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Background and Aim The impact of trace elements and heavy metals on human health has attracted widespread attention. However, the correlation between urinary chromium concentrations and blood pressure remains unclear and inadequately reported, and the aim of this study was to investigate the relationship between urinary chromium concentrations and blood pressure in adults in the United States (US). Methods We utilized data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 for this study. Multivariate logistic regression and multivariate linear regression were used to explore the association of urinary chromium concentrations with hypertension and blood pressure. Additionally, we also performed subgroup analysis and restricted cubic splines (RCS). Results A total of 2958 participants were enrolled in this study. The overall mean systolic blood pressure and diastolic blood pressure were 123.98 ± 0.60, 72.66 ± 0.57 mmHg, respectively. The prevalence of hypertension was found in 41.31% of the whole participants. In the fully adjusted model, we did not observe a correlation between urinary chromium concentrations and the risk of hypertension and systolic blood pressure. However, we found a negative association between urinary chromium concentrations and diastolic blood pressure. In subgroup analysis, we observed a positive association between urinary chromium and the risk of hypertension among participants older than 60 years of age and those who were Non-Hispanic Black. The interaction term highlighted the influence of age and race on this positive association. We also found a negative association of urinary chromium with diastolic blood pressure in male, participants who were current smokers, overweight, and other races, as well as those without alcohol use and anti-hypertensive drug use. However, the interaction term only revealed the influence of alcohol consumption on the negative association. Conclusion Our study suggested that urinary chromium concentrations may show a negative association with diastolic blood pressure and this association was significantly dependent on alcohol consumption. Besides, a positive association between urinary chromium and the risk of hypertension was also found among participants older than 60 years of age and those who were Non-Hispanic Black.

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The Impact of Chromium Supplementation on Blood Pressure: A Systematic Review and Dose–Response Meta‑Analysis of Randomized‑Controlled Trials

Cited by 6 publications

References 47 publications

ESPEN micronutrient guideline

ESPEN micronutrient guideline

Metallomics in pulmonary arterial hypertension patients

The association between the urinary chromium and blood pressure: a population-based study

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