The Impact of Chemotherapy on the Survival of Patients With High-grade Primary Extremity Liposarcoma

Eilber, Fritz C.; Eilber, Frederick R.; Eckardt, Jeffery J.; Rosen, Gerald; Riedel, Elyn; Maki, Robert G.; Brennan, Murray F.; Singer, Samuel

doi:10.1097/01.sla.0000141710.74073.0d

Cited by 142 publications

(117 citation statements)

References 26 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…A number of studies have suggested that chemotherapy may worsen patient prognosis (25,26). Other studies have reported that chemotherapy has limited effectiveness for PRPLS, but is beneficial for liposarcomas originating from the lower or upper extremities (23,27). Radiation can result in clinical complications, including nerve lesions, hydronephrosis, ureteral fistula and ileus (28).…”

Section: Discussionmentioning

confidence: 99%

A retrospective, single‑center cohort study on 65ï¿½patients with primary retroperitoneal liposarcoma

Liu

et al. 2017

Oncol Lett

View full text Add to dashboard Cite

Abstract. Primary retroperitoneal liposarcoma (PRPLS)is the most common soft tissue malignancy of the retroperitoneum. To determine the pathological features and the curative effects of surgery in patients with PRPLS, and to elucidate key prognostic factors, the present study retrospectively analyzed the clinical cases of 65 patients with PRPLS. Immunohistochemical analysis demonstrated that vimentin and Ki-67 are better indicators for PRPLS immunohistochemical diagnosis compared with S-100 protein. S-100 protein was predominantly expressed in well-differentiated PRPLS. Positive expression of vimentin and Ki-67 were observed in almost all PRPLS samples, and Ki-67 exhibited a higher expression level in high-grade PRPLS. The level of Ki-67 expression was negatively correlated with disease-specific survival (DSS). Survival analysis revealed that the pathological subtype and histological grade were associated with DSS and local recurrence in the patients, whereas the tumor burden was associated with DSS but not local recurrence. In addition, complete tumor resection and contiguous organ resection were able to improve DSS. Microscopically positive margins did not affect DSS, whereas gross margins did. Multivariate analysis revealed that pathological subtype, histological grade and contiguous organ resection were independent prognostic factors, and that histological grade was an independent factor for local recurrence. Patient sex and age at presentation were not independent factors associated with prognosis or local recurrence. Correlation analysis demonstrated that postoperative local recurrence significantly affected DSS, and local recurrence was the most common cause of mortality among patients. Histological grade was strongly associated with the invasion of adjacent organs but not with tumor burden. Furthermore, the tumor burden was not associated with recurrence or tumor invasion of adjacent organs. Ki-67 expression was associated with prognosis. Pathological subtype, histological grade and contiguous organ resection were independent prognostic factors, while histological grade was an independent factor which affected tumor recurrence.

show abstract

Section: Discussionmentioning

confidence: 99%

A retrospective, single‑center cohort study on 65ï¿½patients with primary retroperitoneal liposarcoma

Liu

et al. 2017

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…In addition, studies often mix up different groups of patients. [17][18][19][20][21][22][23][24][25] Therefore, most guidelines for clinical practice are based on phase 2 studies and historic comparisons. This emphasizes the importance of predictive and prognostic factors.…”

Section: Discussionmentioning

confidence: 99%

The prognostic impact of dedifferentiation in retroperitoneal liposarcoma

Mussi

Collini

Miceli³

et al. 2008

Cancer

View full text Add to dashboard Cite

BACKGROUND.A series of patients with well differentiated (WD)/dedifferentiated (DD) retroperitoneal liposarcoma (RLS) was studied to evaluate the prognostic value of the presence, extension, and grade of the DD component.METHODS.Among 148 patients with RLS who underwent surgery over 20 years, the authors retrieved data on patients who had localized WD/DD RLS. For the current analysis, patients were included only if they had primary disease or a first recurrence at their initial presentation. The DD component, when present, was graded according to National Federation of Centers in the Fight Against Cancer (FNCLCC) criteria, and the extension of the DD component was described as a percentage. Univariate and multivariate analyses were carried out for local recurrence‐free survival (LRFS), event‐free survival (EFS), and disease‐specific survival (DSS).RESULTS.Of 93 patients who were identified, 36 patients (39%) had WD RLS, and 57 patients (61%) had DD RLS. The median follow‐up was 71 months (range, 28‐132 months). Seven patients (7.5%) developed distant metastases, including 5 patients who had DD RLS. The 5‐year DSS rate was 42% in patients with DD RLS and 71.6% in patients with WD RLS (P = .018). The corresponding rates for LRFS were 22% and 43.3%, respectively (P = .007). The presence of the DD component and its FNCLCC grade were independent prognostic factors for DSS and LRFS. The administration of radiation therapy was associated independently with better LRFS.CONCLUSIONS.Patients with high‐grade DD RLS had a worse prognosis in terms of both DSS and LRFS. The extension of the DD component and its mitotic index were relevant for EFS. The results indicated that radiation therapy may improve LRFS. These data may help stratify the risk of recurrence for patients with RLS. Clinical studies on new multimodality approaches are warranted. Cancer 2008. © 2008 American Cancer Society.

show abstract

“…Patients underwent a whole-body PET/CT before initiating neoadjuvant therapy (Baseline study). The mean interval between the baseline PET/CT and initiation of neoadjuvant therapy was 7 days (mean, 6.5; range, [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. After completion of neoadjuvant therapy and before surgery, patients underwent a second whole-body PET/CT (posttreatment study).…”

Section: Methodsmentioning

confidence: 99%

Reduction of Glucose Metabolic Activity Is More Accurate than Change in Size at Predicting Histopathologic Response to Neoadjuvant Therapy in High-Grade Soft-Tissue Sarcomas

Evilevitch¹,

Weber

Tap

et al. 2008

Clinical Cancer Research

Self Cite

177

View full text Add to dashboard Cite

Purpose: Change in tumor size as classified by Response Evaluation Criteria in Solid Tumors poorly correlates with histopathologic response to neoadjuvant therapy in patients with softtissue sarcomas. The aim of this study was to prospectively evaluate whether positron emission tomography with 18 F-fluorodeoxyglucose (FDG-PET) allows for a more accurate evaluation of histopathologic response. Experimental Design: From January 2005 to January 2007, 42 patients with resectable biopsy-proven high-grade soft-tissue sarcoma underwent a FDG-PET/computed tomography scan before and after neoadjuvant treatment. Relative changes in tumor FDG uptake and size from the baseline to the follow-up scan were calculated, and their accuracy for assessment of histopathologic response was compared by receiver operating characteristic curve analysis. Histopathologic response was defined as z95% tumor necrosis. Results: In histopathologic responders (n = 8; 19%), reduction in tumor FDG uptake was significantly greater than in nonresponders (P < 0.001), whereas no significant differences were found for tumor size (P = 0.24). The area under the receiver operating characteristic curve for metabolic changes was 0.93, but only 0.60 for size changes (P = 0.004). Using a 60% decrease in tumor FDG uptake as a threshold resulted in a sensitivity of 100% and a specificity of 71% for assessment of histopathologic response, whereas Response Evaluation Criteria in Solid Tumors showed a sensitivity of 25% and a specificity of 100%. Conclusion: Quantitative FDG-PET was significantly more accurate than size-based criteria at assessing histopathologic response to neoadjuvant therapy. FDG-PETshould be considered as a modality to monitor treatment response in patients with high-grade soft-tissue sarcoma.

show abstract

The Impact of Chemotherapy on the Survival of Patients With High-grade Primary Extremity Liposarcoma

Abstract: In patients with large, high-grade, primary extremity liposarcoma; DOX is not associated with improved DSS and IF is associated with an improved DSS. Treatment with IF should be considered in patients with high-risk primary extremity liposarcoma.

Cited by 142 publications

References 26 publications

A retrospective, single‑center cohort study on 65ï¿½patients with primary retroperitoneal liposarcoma

A retrospective, single‑center cohort study on 65ï¿½patients with primary retroperitoneal liposarcoma

The prognostic impact of dedifferentiation in retroperitoneal liposarcoma

Reduction of Glucose Metabolic Activity Is More Accurate than Change in Size at Predicting Histopathologic Response to Neoadjuvant Therapy in High-Grade Soft-Tissue Sarcomas

Contact Info

Product

Resources

About