The impact of cancer and quality of life among long-term survivors of breast cancer in Austria

Bouskill, Kathryn E.; Kramer, Michael R.

doi:10.1007/s00520-016-3319-7

Cited by 23 publications

(28 citation statements)

References 40 publications

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“…Similar results on the longterm impairment in QoL and HRQoL have been previously reported, although they have been somewhat conflicting (6)(7)(8)(9)(24)(25)(26)(27)(28). Several studies have revealed that especially i) sleep (6,7,24,27), ii) cognitive function (6,8,24,(27)(28), iii) fatigue (6,7,27), iv) emotional functioning (6,7,9,26) and v) mental health (6,9,27,29) remain impaired years after diagnosis and treatment. In our study, the BCS were worse off compared to the general population on the dimensions of i) sleeping, ii) excretion, iii) mental function, and iv) sexual activity still five years after treatment.…”

Section: Discussionsupporting

confidence: 69%

Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study: A Five-year Follow-up

Roine

Sintonen

Kellokumpu‐Lehtinen

et al. 2020

In Vivo

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Background/Aim: As the number of breast cancer survivors is increasing, their long-term health-related quality of life (HRQoL) has become an important issue. The aim of the study is to follow up the HRQoL of breast cancer survivors (BCS) in a prospective randomized exercise intervention study and to compare HRQoL to that of the agematched general female population. Patients and Methods: Following adjuvant treatment, 537 patients aged 35-68 and capable of exercise training were randomized to a 12-month exercise trial. In 182 of those patients, HRQoL was measured by the generic 15D at baseline and followed up for five years. Furthermore, the HRQoL of all BCS answering the 15D at five-year follow-up (n=390) was compared to that of a representative sample of the general population. Results: After five years, the BCS' mean HRQoL demonstrated a statistically and clinically significant impairment compared to that of the general population (difference-0.023, p<0.001). The mean HRQoL of BCS followed up from baseline until five years did not improve significantly (change=0.007, p=0.27), whereas the dimensions of usual activities (0.043, p=0.004), depression (0.038, p=0.007), distress (0.030, p=0.036), and sexual activity (0.057, p=0.009) did. Conclusion: The HRQoL of BCS was still impaired five years following treatment. The prognosis of breast cancer has improved dramatically during the last decades and this, together with an increasing incidence and an aging population, has led to a greater number of breast cancer survivors (BCS) (1, 2). The improved prognosis of breast cancer is largely due to early detection with comprehensive screening, and advanced surgical and adjuvant treatments. Adjuvant treatments of breast cancer clearly improve patients' survival, however, effective treatments have severe adverse effects that compromise patients' wellbeing (3-5). Consequently, many BCS suffer from numerous long-term cancer-and treatmentrelated adverse effects and impaired health-related quality of life (HRQoL) even years after the diagnosis and treatment (6-9). With an increasing population of BCS, it is essential to investigate their long-term perceived health and wellbeing and to identify those with impairments in HRQoL to be able to focus on their rehabilitation after breast cancer treatment. Studies focusing on HRQoL in breast cancer have often used disease-specific instruments (5, 10). Disease-specific 667 This article is freely accessible online.

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Section: Discussionsupporting

confidence: 69%

Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study: A Five-year Follow-up

Roine

Sintonen

Kellokumpu‐Lehtinen

et al. 2020

In Vivo

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“…In particular, life interference associated with both QoL dimensions, the Meaning of cancer and body image concerns associated with physical functioning, and appearance concerns associated with mental functioning. Since the eight IOC‐V2 subscales, rather than the two summary scores, were used as regressors, our findings reinforce and expand the findings of Bouskill (), who reported that the positive impact of cancer associated with improved physical functioning, while the negative impact of cancer associated with poorer physical and mental functioning in long‐term survivors. In addition, our results expand other studies that demonstrated the influence of psychosocial aspects on long‐term cancer survivors’ QoL (e.g., Annunziata et al, ).…”

Section: Discussionsupporting

confidence: 87%

“…The state of having cancer, or having had the disease, has a wide range of psychological impacts, both negative and positive, that seem to be related to QoL (Bouskill, ; Crespi, Ganz, Petersen, Castillo, & Caan, ; Crespi, Smith, Petersen, Zimmerman, & Ganz, ; Oerlemans et al, ; Sarker et al, ; Smith, Crespi, Petersen, Zimmerman, & Ganz, ). Negative impacts include uncertainty and concern for the future and for one's own health (including the possibility of getting sick again), worries about one's body strength and functionality and the impossibility of returning to pre‐disease conditions, concerns about body image, and the interference of the disease on one's past, present and future.…”

Section: Introductionmentioning

confidence: 99%

“…In 2015, Annunziata et al reported that negative psychological factors (depressive and anxious states) explained QoL scores of cancer survivors who had been free of the disease and its treatments for at least 5 years. Bouskill (), studying breast cancer survivors, found that a perceived positive impact of cancer was associated with improved physical functioning, while a perceived negative impact of cancer was associated with poorer physical and mental functioning.…”

Section: Introductionmentioning

confidence: 99%

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The impact of cancer: An Italian descriptive study involving 500 long‐term cancer survivors

et al. 2019

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Introduction The well‐being and quality of life (QoL) of long‐term cancer survivors may be affected, both positively and negatively, by psychosocial factors related to the experience of being a cancer patient. We investigated whether, in long‐term cancer survivors, the psychosocial impacts of cancer associate with socio‐demographic–clinical variables; whether, within the positive and negative dimensions taken separately, some impacts are more intense than others; and whether these impacts explain QoL. Methods Italian long‐term cancer survivors (n = 500) completed the Impact of Cancer (IOC‐V2) and Short Form 36 Health Survey (SF‐36) questionnaires. Results The IOC‐V2 negative impact score associated with gender, education, occupational status and health issues, whereas no association was found between the positive impact score and socio‐demographic–clinical variables. Of the positive impacts, Altruism/Empathy was the highest (p < 0.001); Positive self‐evaluation was higher than Health awareness (p = 0.001); and Meaning of cancer was the lowest (p < 0.001). Among the negative impacts, Worry was the highest (p < 0.001), whereas Body changes concerns was higher than both Appearance concerns (p < 0.001) and Life Interferences (p < 0.001). The assessed impacts explained more than 25% of the variance of both physical and mental functioning scores. Conclusions The provided data document psychosocial factors affecting QoL in Italian long‐term cancer survivors.

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“…This survey is a widely used health survey which has been used extensively in breast cancer survivors [73–79]. It includes 36 items covering eight health domains: physical functioning, bodily pain, role limitations due to physical health problems, role limitations due to personal or emotional problems, emotional well-being, social functioning, energy/fatigue, and general health perceptions.…”

Section: Methodsmentioning

confidence: 99%

The women in steady exercise research (WISER) survivor trial: The innovative transdisciplinary design of a randomized controlled trial of exercise and weight-loss interventions among breast cancer survivors with lymphedema

Winkels

Kallan

Dean

et al. 2017

Contemporary Clinical Trials

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Introduction Breast cancer survivors face dual challenges: long term sequelae of treatment, and risk of recurrent disease. Obesity and a sedentary lifestyle complicate both challenges. The WISER Survivor trial assessed the effects of exercise and/or weight-loss on lymphedema, biomarkers of breast cancer recurrence, and quality of life. We report on the innovative transdisciplinary design of this trial and report attrition rates. Methods This one year trial randomized breast cancer survivors who had a BMI of ≥25 kg/m2, were sedentary and had breast-cancer-related-lymphedema to 1) exercise (weight training and aerobic exercise) 2) weight-loss 3) exercise and weight-loss 4) or control group. Innovative aspects included: adaptation of a community-based weight training program to a largely home-based program; use of a commercial meal replacement system as part of the lifestyle modification weight-loss program; inclusion of measures of cost-effectiveness to enable economic evaluations; and alignment with a parallel mouse model for breast cancer recurrence to enable transdisciplinary research. In this model, mice bearing dormant residual tumor cells, which spontaneously relapse, were placed on a high-fat diet. Overweight animals were randomly assigned to exercise, calorie restriction, both, or control group and followed for cancer recurrence. The animal model will guide mechanistic biomarkers to be tested in the human trial. Results & discussion 351 participants were randomized; 13 experienced breast cancer recurrence during the trial. Of the 338 participants without recurrence, 83% completed the trial. The WISER Survivor trial will show the effects of exercise and weight-loss on lymphedema outcomes, biomarkers of recurrence and quality of life. NCT ClinicalTrials.gov registration #: NCT01515124

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The impact of cancer and quality of life among long-term survivors of breast cancer in Austria

Abstract: Long-term survivors of breast cancer in Austria perceive both positive and negative impacts of breast cancer. These perceptions, in particular the negative impact of cancer, appear to influence, or are potentially influenced by, physical and mental health-related quality of life.

Cited by 23 publications

References 40 publications

Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study: A Five-year Follow-up

Health-related Quality of Life of Breast Cancer Survivors Attending an Exercise Intervention Study: A Five-year Follow-up

The impact of cancer: An Italian descriptive study involving 500 long‐term cancer survivors

The women in steady exercise research (WISER) survivor trial: The innovative transdisciplinary design of a randomized controlled trial of exercise and weight-loss interventions among breast cancer survivors with lymphedema

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