The Impact of Body Mass Index on Heterotopic Ossification

Indomethacin Prophylaxis for Heterotopic Ossification after Acetabular Fracture Surgery Increases the Risk for Nonunion of the Posterior Wall

“…[2][3][4][5] The etiology of HO remains inadequately understood. [14][15][16][17][18][19][20] Because of the ample evidence to support an inflammatory etiology, one such prophylactic measure has been the use of nonsteroidal anti-inflammatory (NSAID) medications, whose first use in prophylaxis against HO after athroplasty is credited to Dahl. [6][7][8][9][10][11][12][13] Prophylactic measures may be used to mitigate HO formation and the resultant decreased range of motion and pain in situations where the risk of postoperative HO is deemed to be unacceptably high.…”

Effectiveness of Radiotherapy in Heterotopic Ossification

“…It is recommended to apply early postoperative radiotherapy at fractionated doses (total dose of 10 Gy) or at a dose of 6-8 Gy at single fraction in order to prevent recurrence after surgery. Previous studies demonstrated that there was no difference between single dose and fractionated doses [9,14,15,17,21,22]. However, single dose radiotherapy is more widely preferred due to its ease application.…”

Testicular Dose During Prophylaxis of Heterotopic Ossification with Radiation Therapy

“…All surgical procedures were performed by fellowship trained, orthopedic trauma surgeons. All patients underwent ORIF via a posteriorly approached (Kocher-Langenbeck) surgical exposure with the patient in either lateral or prone position (15,16). Early postoperative patient mobilization, with toe-touch weight bearing as tolerated, was initiated for all patients.…”

“…Seven hundred cGy was delivered in a single fraction to the mid-plane, using 6-18 MV photons. Treatment fields included the soft tissues around the proximal femur and acetabulum without bone shielding (15)(16)(17). Five different treatment plans were generated after CT simulation (the process used to determine the exact location, shape and size of the targeted area to be treated) to investigate the testicular doses.…”

“…Additional treatment planning trials were created for each patient by utilizing a SBT medially and by using different photon energies (6,10 and 18 MV) to study the effects of these maneuvers on the delivered dose to the testicles. Results (10)(11)(12)(13)(14)(15)(16)(17)(18) Heterotopic ossification (HO) is the pathological process of bone formation in non-osseous tissues following trauma and/or surgical intervention. Following traumatic injury, cellular and hormonal signals from the site of injury, a supply of mesenchymal cells and the appropriate tissue microenvironment are all among the potential factors that could contribute to development of HO in injured tissues (1).…”