The impact of biopsy technique on upstaging, residual disease, and outcome in cutaneous melanoma

Egnatios, Genevieve L.; Dueck, Amylou C.; Macdonald, James B.; Laman, Susan D.; Warschaw, Karen E.; DiCaudo, David J.; Nemeth, Shari A.; Sekulić, Aleksandar; Gray, Richard; Wasif, Nabil; Pockaj, Barbara A.

doi:10.1016/j.amjsurg.2011.06.037

Cited by 43 publications

(71 citation statements)

References 18 publications

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“…Shave biopsies are more likely to result in a (+) DM when compared to punch or excision biopsies . Shave biopsies remain the most frequently performed type of biopsy in patients with pigmented lesions, however, despite an increased risk of transecting the tumor.…”

Section: Discussionmentioning

confidence: 99%

Transected thin melanoma: Implications for sentinel lymph node staging

Herbert

Karakousis

Bartlett

et al. 2017

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 99%

Transected thin melanoma: Implications for sentinel lymph node staging

Herbert

Karakousis

Bartlett

et al. 2017

Journal of Surgical Oncology

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“…When controlling for Breslow's depth, these tumors also had similar survival as non‐transected tumors. Studies examining survival for these patients are rare . Molenkamp and colleagues suggested that the presence of residual tumor cells after initial biopsy actually conferred a better prognosis .…”

Section: Discussionmentioning

confidence: 99%

“…The melanoma is then subsequently excised to remove the remaining tumor, and management differs by institution on how aggressive to treat a patient given an indeterminate tumor depth. A recent study determined that shave biopsies result in T‐upstaging for a small percentage of patients after wide local excision, and that negative margins do not necessary preclude T‐upstaging …”

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confidence: 99%

Prognosis of Patients with Transected Melanomas

Martires

Nandi

Honda

et al. 2013

Dermatologic Surgery

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“…[4][5][6][7][8][9][10][11][12][13][14] The idea against non-excisional biopsies is that punch, shaving or otherwise partial biopsy could facilitate the spread of tumour cells in the subcutaneous tissue and blood vessels, thus worsening patient's prognosis. [4][5][6][7][8][9][10][11][12][13][14] The idea against non-excisional biopsies is that punch, shaving or otherwise partial biopsy could facilitate the spread of tumour cells in the subcutaneous tissue and blood vessels, thus worsening patient's prognosis.…”

Section: Introductionmentioning

confidence: 99%

A meta‐analysis on the influence of partial biopsy of primary melanoma on disease recurrence and patient survival

Moscarella

Pampena

Palmiotti

et al. 2019

Acad Dermatol Venereol

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Background Complete surgical excision is the preferred biopsy type for suspicious melanocytic lesions. However, partial biopsy is sometimes used in special situations. Previous studies have explored the effect of partial biopsy of a primary melanoma on patient outcome with controversial results. Objective We performed a meta‐analysis on the influence of the type of biopsy of a primary melanoma on recurrence‐free survival (RFS) and melanoma‐related survival (MRS). Methods Clinical trials, observational cohort studies and case–control studies reporting absolute number of recurrences and/or melanoma‐related deaths in patients undergoing a partial or excisional biopsy of melanoma were included in the meta‐analysis. Results In all, the five included studies reported 3249 patients, 1121 (34.5%) of them in the partial biopsy group and 2128 (65.5%) in the excisional biopsy group. Despite a trend in favour of excisional biopsy in reducing the risk for recurrences, the forest plot related to RFS failed to demonstrate significant differences among groups (RR: 1.27; 95% CI 0.97–1.67; P: 0.09; random effects; I2: 55%). The forest plot showed no difference in the risk of dying for melanoma‐related causes for patients undergoing partial biopsy vs. excisions biopsy (RR: 1.50; 95% CI 0.98–2.30; P: 0.06; random effects; I2: 60%). Limitations The majority of the studies were retrospective, and follow‐up time was not uniform among studies and not always reported. Conclusion In conclusion, a partial biopsy can be performed in special situations, such as large primary tumours located in surgically sensitive areas, without altering MRS and RFS.

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The impact of biopsy technique on upstaging, residual disease, and outcome in cutaneous melanoma

Cited by 43 publications

References 18 publications

Transected thin melanoma: Implications for sentinel lymph node staging

Transected thin melanoma: Implications for sentinel lymph node staging

Prognosis of Patients with Transected Melanomas

A meta‐analysis on the influence of partial biopsy of primary melanoma on disease recurrence and patient survival

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