The impact of bioceramic nanocarriers on the intranasal delivery of zaleplon nanoscale powder through new adsorption techniques: Improvement in bioavailability and hypnotic effect

Latif, Randa; Makar, Rana R.; Hosni, Ehab A.; El‐Gazayerly, Omaima N.

doi:10.1016/j.jddst.2019.101375

Cited by 3 publications

(2 citation statements)

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“…For example, the adsorption of zaleplon onto HNTs significantly increased the mucosal permeability of the nasal spray, resulting in a 2.4-fold increase in bioavailability. 188 HNTs' needle-like shape was exploited to develop a "nano-torpedo" to deliver drugs across the bloodbrain barrier into the brains of mice through intranasal administration. 189 HNT rectal formulations are expected to increase bioavailability and provide a long-term effect.…”

Section: Motion Sensingmentioning

confidence: 99%

“…HNT formulations can be used for nasal, vaginal, and rectal administration to enhance the mucosal permeability of the drug. For example, the adsorption of zaleplon onto HNTs significantly increased the mucosal permeability of the nasal spray, resulting in a 2.4-fold increase in bioavailability . HNTs’ needle-like shape was exploited to develop a “nano-torpedo” to deliver drugs across the blood-brain barrier into the brains of mice through intranasal administration .…”

Section: Biomedical Applicationsmentioning

confidence: 99%

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The Horizons of Medical Mineralogy: Structure-Bioactivity Relationship and Biomedical Applications of Halloysite Nanoclay

Feng,

Chen,

et al. 2024

ACS Nano

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Medical mineralogy explores the interactions between natural minerals and living organisms such as cells, tissues, and organs and develops therapeutic and diagnostic applications in drug delivery, medical devices, and healthcare materials. Many minerals (especially clays) have been recognized for pharmacological activities and therapeutic potential. Halloysite clay (Chinese medicine name: Chishizhi), manifested as onedimensional aluminum silicate nanotubes (halloysite nanotubes, HNTs), has gained applications in hemostasis, wound repair, gastrointestinal diseases, tissue engineering, detection and sensing, cosmetics, and daily chemicals formulations. Various biomedical applications of HNTs are derived from hollow tubular structures, high mechanical strength, good biocompatibility, bioactivity, and unique surface characteristics. This natural nanomaterial is safe, abundantly available, and may be processed with environmentally safe green chemistry methods. This review describes the structure and physicochemical properties of HNTs relative to bioactivity. We discuss surface area, porosity and surface defects, hydrophilicity, heterogeneity and charge of external and internal surfaces, as well as biosafety. The paper provides comprehensive guidance for the development of this tubule nanoclay and its advanced biomedical applications for clinical diagnosis and therapy.

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Section: Motion Sensingmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%