The impact of atypical sensory processing on social impairments in autism spectrum disorder

Thye, Melissa; Bednarz, Haley M.; Herringshaw, Abbey J.; Sartin, Emma B.; Kana, Rajesh K.

doi:10.1016/j.dcn.2017.04.010

Cited by 342 publications

(293 citation statements)

References 400 publications

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“…Studies in older children have shown similar associations between greater ASD symptomology and reduced resting-state fc between the visual network and other large-scale functional networks including motor and salience networks (74, 81). Given previous studies that have linked RRBs to atypical sensory response patterns including hyper responsivity to sensory stimuli and sensory seeking behavior (9–11, 14), our findings support the hypothesis that early disordered fc involving the visual network may engender later disruptions in higher order behaviors (82, 83). …”

Section: Discussionsupporting

confidence: 87%

Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder

Eggebrecht

Todorov

et al. 2019

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Background Restricted and repetitive behaviors (RRBs), detectable by 12 months (mo) in many infants later diagnosed with autism spectrum disorder (ASD), may represent some of the earliest behavioral markers of ASD. However, brain function underlying the emergence of these key behaviors remains unknown. Methods Behavioral and resting-state functional connectivity (fc) magnetic resonance imaging data were collected from 167 children at high and low familial risk for ASD at 12 and 24mo (n=38 at both time points). Twenty infants met criteria for ASD at 24 mo. We divided RRBs intofour subcategories (restricted, stereotyped, ritualistic/sameness, self-injurious) and used a data-driven approach to identify functional brain networks associated with the development of each RRB subcategory. Results Higher scores for ritualistic/sameness behavior were associated with less positive fc between visual and control networks at 12 and 24 mo. Ritualistic/sameness and stereotyped behaviors were associated with less positive fc between visual and default mode networks at 12 mo. At 24 mo, stereotyped and restricted behaviors were associated with more positive fc between default mode and control networks. Additionally, at 24 mo, stereotyped behavior was associated with more positive fc between dorsal attention and subcortical networks, while restricted behavior was associated with more positive fc between default mode and dorsal attention networks. No significant network-level associations were observed for self-injurious behavior. Conclusion These observations mark the earliest known description of functional brain systems underlying RRBs, reinforce the construct validity of RRB subcategories in infants, and implicate specific neural substrates for future interventions targeting RRBs.

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Section: Discussionsupporting

confidence: 87%

Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder

Eggebrecht

Todorov

et al. 2019

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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“…Exploring this matter further could yield insights as to developmental mechanisms underlying the emergence of ASD as well as provide new targets for screening and intervention. For example, several theoretical models posit that altered processing of sensory stimuli in infancy might contribute directly to the accumulation of later‐emerging social communication deficits in children with ASD (Thye, Bednarz, Herringshaw, Sartin, & Kana, ). Alternatively, it is plausible that our results reflect a more complex truth, wherein response patterns within and between children are characterized by high levels of variability and heterogeneity, reflecting the interplay of multiple aspects of development during a period of rapid maturation.…”

Section: Discussionmentioning

confidence: 99%

A longitudinal study of parent‐reported sensory responsiveness in toddlers at‐risk for autism

Wolff

Dimian

Botteron

et al. 2018

Child Psychology Psychiatry

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Background Atypical sensory responsivity and sensory interests are now included in the DSM 5 diagnostic criteria for autism spectrum disorder (ASD) under the broad domain of restricted and repetitive behavior (RRB). However, relatively little is known about the emergence of sensory‐related features and their relation to conventionally defined RRB in the first years of life. Methods Prospective, longitudinal parent‐report data using the Sensory Experiences Questionnaire (SEQ) were collected for 331 high‐risk toddlers (74 of whom met diagnostic criteria for ASD at age 2) and 135 low‐risk controls. Longitudinal profiles for SEQ scores were compared between groups across ages 12–24 months. Associations between SEQ measures and measures of RRB subtypes (based on the Repetitive Behavior Scale, Revised) were also examined. Results Longitudinal profiles for all SEQ scores significantly differed between groups. SEQ scores were elevated for the ASD group from age 12 months, with differences becoming more pronounced across the 12–24 month interval. At both 12 and 24 months, most measures derived from the SEQ were significantly associated with all subtypes of RRB. Conclusions These findings suggest that differences in sensory responsivity may be evident in high‐risk infants later diagnosed with ASD in early toddlerhood, and that the magnitude of these differences increases over the second year of life. The high degree of association between SEQ scores and RRB supports the conceptual alignment of these features but also raises questions as to explanatory mechanisms.

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“…Abnormalities in ASD are reported in all sensory domains (Thye, Bednarz, Herringshaw, Sartin, & Kana, 2018) and are linked to a disturbed underlying neural processing (Kern et al, 2007). For example, compared to typically developing children, children with ASD have a delay in the identification of speech syllables in lip-reading tasks and are less likely to integrate the audio-visual information obtained by the McGurk effect (Taylor, Isaac, & Milne, 2010).…”

Section: Introductionmentioning

confidence: 99%

Audio–visual and olfactory–visual integration in healthy participants and subjects with autism spectrum disorder

Stickel

Weismann

Kellermann

et al. 2019

Human Brain Mapping

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The human capacity to integrate sensory signals has been investigated with respect to different sensory modalities. A common denominator of the neural network underlying the integration of sensory clues has yet to be identified. Additionally, brain imaging data from patients with autism spectrum disorder (ASD) do not cover disparities in neuronal sensory processing. In this fMRI study, we compared the underlying neural networks of both olfactory–visual and auditory–visual integration in patients with ASD and a group of matched healthy participants. The aim was to disentangle sensory‐specific networks so as to derive a potential (amodal) common source of multisensory integration (MSI) and to investigate differences in brain networks with sensory processing in individuals with ASD. In both groups, similar neural networks were found to be involved in the olfactory–visual and auditory–visual integration processes, including the primary visual cortex, the inferior parietal sulcus (IPS), and the medial and inferior frontal cortices. Amygdala activation was observed specifically during olfactory–visual integration, with superior temporal activation having been seen during auditory–visual integration. A dynamic causal modeling analysis revealed a nonlinear top‐down IPS modulation of the connection between the respective primary sensory regions in both experimental conditions and in both groups. Thus, we demonstrate that MSI has shared neural sources across olfactory–visual and audio–visual stimulation in patients and controls. The enhanced recruitment of the IPS to modulate changes between areas is relevant to sensory perception. Our results also indicate that, with respect to MSI processing, adults with ASD do not significantly differ from their healthy counterparts.

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The impact of atypical sensory processing on social impairments in autism spectrum disorder

Cited by 342 publications

References 400 publications

Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder

Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder

A longitudinal study of parent‐reported sensory responsiveness in toddlers at‐risk for autism

Audio–visual and olfactory–visual integration in healthy participants and subjects with autism spectrum disorder

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