The impact of attentional and emotional demands on memory performance in obsessive-compulsive disorder

Altered resting-state cerebellar-cerebral functional connectivity in obsessive-compulsive disorder

“…The ECN, often characterized as a task-positive network, mainly encompasses dorso-lateral prefrontal cortex, posterior parietal cortex, angular gyrus and occipital cortex, and is associated with the performance of cognitively demanding tasks (Sridharan et al ., 2008). A growing number of studies have reported that patients with OCD exhibit altered functional connectivity within and between the DMN and ECN (Peng et al ., 2014; Chen et al ., 2016; Fan et al ., 2017), which may be associated with impairment of monitoring and goal-directed behavior (Fink et al ., 2017; Vaghi et al ., 2017). In addition, neuroimaging studies have revealed abnormal activation and connectivity in motor network and frontal-limbic circuits in patients with OCD (Mantovani et al ., 2013; de Vries et al ., 2017), associated with inhibition deficits and dysregulation of emotion (Heinzel et al ., 2017; Thorsen et al ., 2018) in this condition.…”